SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e8g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 2e8g HYPOTHETICAL PROTEIN
PH0536
(Pyrococcus
horikoshii) 		5 / 12 LEU A 202
VAL A 184
THR A 158
VAL A 169
GLY A 207
 None
 1.17A 2cbrA-2e8gA:
undetectable		 2cbrA-2e8gA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 2e8g HYPOTHETICAL PROTEIN
PH0536
(Pyrococcus
horikoshii) 		4 / 4 LEU A 124
PRO A  59
LEU A  62
ARG A  53
 None
 1.25A 2hrcA-2e8gA:
undetectable		 2hrcA-2e8gA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 2e8g HYPOTHETICAL PROTEIN
PH0536
(Pyrococcus
horikoshii) 		4 / 4 LEU A 124
PRO A  59
LEU A  62
ARG A  53
 None
 1.33A 2hrcB-2e8gA:
undetectable		 2hrcB-2e8gA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 2e8g HYPOTHETICAL PROTEIN
PH0536
(Pyrococcus
horikoshii) 		3 / 3 LEU A 126
ARG A 123
ILE A 129
 None
 0.58A 2xn5B-2e8gA:
undetectable		 2xn5B-2e8gA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2e8g HYPOTHETICAL PROTEIN
PH0536
(Pyrococcus
horikoshii) 		4 / 4 LEU A 124
PRO A  59
LEU A  62
ARG A  53
 None
 1.25A 3hcoB-2e8gA:
undetectable		 3hcoB-2e8gA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 2e8g HYPOTHETICAL PROTEIN
PH0536
(Pyrococcus
horikoshii) 		5 / 10 VAL A 182
VAL A 184
LEU A 186
GLY A 141
GLY A 217
 None
 1.14A 3ls4H-2e8gA:
undetectable		 3ls4H-2e8gA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2e8g HYPOTHETICAL PROTEIN
PH0536
(Pyrococcus
horikoshii) 		4 / 8 TRP A   2
THR A   4
TYR A   8
LEU A 124
 None
 1.17A 3wipG-2e8gA:
undetectable
3wipH-2e8gA:
undetectable		 3wipG-2e8gA:
19.92
3wipH-2e8gA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2e8g HYPOTHETICAL PROTEIN
PH0536
(Pyrococcus
horikoshii) 		4 / 8 LEU A 124
TRP A   2
THR A   4
TYR A   8
 None
 1.15A 3wipF-2e8gA:
undetectable
3wipJ-2e8gA:
undetectable		 3wipF-2e8gA:
19.92
3wipJ-2e8gA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2e8g HYPOTHETICAL PROTEIN
PH0536
(Pyrococcus
horikoshii) 		4 / 5 LEU A  41
PHE A  20
ILE A  39
ILE A  24
 None
 0.98A 5dzk4-2e8gA:
undetectable
5dzkg-2e8gA:
undetectable
5dzkm-2e8gA:
undetectable
5dzkn-2e8gA:
undetectable		 5dzk4-2e8gA:
1.28
5dzkg-2e8gA:
20.73
5dzkm-2e8gA:
22.57
5dzkn-2e8gA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2e8g HYPOTHETICAL PROTEIN
PH0536
(Pyrococcus
horikoshii) 		4 / 8 SER A  16
ALA A  13
MET A  45
LEU A 118
 None
 1.20A 5dzkF-2e8gA:
undetectable
5dzkT-2e8gA:
undetectable		 5dzkF-2e8gA:
20.73
5dzkT-2e8gA:
1.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 2e8g HYPOTHETICAL PROTEIN
PH0536
(Pyrococcus
horikoshii) 		4 / 5 PHE A  20
PHE A 112
LEU A  19
LEU A  71
 None
 1.13A 5veuH-2e8gA:
undetectable		 5veuH-2e8gA:
20.67