SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e8m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2e8m EPIDERMAL GROWTH
FACTOR RECEPTOR
KINASE SUBSTRATE 8
(Homo
sapiens) 		4 / 7 LYS A  69
LEU A  72
LEU A  64
PHE A  65
 None
 0.90A 1v55P-2e8mA:
undetectable
1v55W-2e8mA:
undetectable		 1v55P-2e8mA:
18.67
1v55W-2e8mA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2e8m EPIDERMAL GROWTH
FACTOR RECEPTOR
KINASE SUBSTRATE 8
(Homo
sapiens) 		4 / 7 LYS A  69
LEU A  72
LEU A  64
PHE A  65
 None
 0.98A 2dysP-2e8mA:
undetectable
2dysW-2e8mA:
undetectable		 2dysP-2e8mA:
18.67
2dysW-2e8mA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2e8m EPIDERMAL GROWTH
FACTOR RECEPTOR
KINASE SUBSTRATE 8
(Homo
sapiens) 		4 / 7 LYS A  69
LEU A  72
LEU A  64
PHE A  65
 None
 0.97A 2eijP-2e8mA:
undetectable
2eijW-2e8mA:
undetectable		 2eijP-2e8mA:
18.67
2eijW-2e8mA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2e8m EPIDERMAL GROWTH
FACTOR RECEPTOR
KINASE SUBSTRATE 8
(Homo
sapiens) 		4 / 8 LYS A  69
LEU A  72
LEU A  64
PHE A  65
 None
 0.98A 2eilP-2e8mA:
undetectable
2eilW-2e8mA:
undetectable		 2eilP-2e8mA:
18.67
2eilW-2e8mA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 2e8m EPIDERMAL GROWTH
FACTOR RECEPTOR
KINASE SUBSTRATE 8
(Homo
sapiens) 		4 / 6 LEU A  64
SER A  66
PHE A  65
ILE A  86
 None
 0.98A 3ko0B-2e8mA:
undetectable		 3ko0B-2e8mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 2e8m EPIDERMAL GROWTH
FACTOR RECEPTOR
KINASE SUBSTRATE 8
(Homo
sapiens) 		5 / 12 LEU A  64
SER A  66
PHE A  65
ILE A  86
LEU A  72
 None
 1.16A 3ko0K-2e8mA:
0.0
3ko0L-2e8mA:
undetectable
3ko0S-2e8mA:
undetectable
3ko0T-2e8mA:
undetectable		 3ko0K-2e8mA:
20.00
3ko0L-2e8mA:
20.00
3ko0S-2e8mA:
20.00
3ko0T-2e8mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 2e8m EPIDERMAL GROWTH
FACTOR RECEPTOR
KINASE SUBSTRATE 8
(Homo
sapiens) 		5 / 12 LEU A  72
LEU A  64
SER A  66
PHE A  65
ILE A  86
 None
 1.21A 3ko0K-2e8mA:
undetectable
3ko0L-2e8mA:
undetectable
3ko0M-2e8mA:
undetectable
3ko0N-2e8mA:
undetectable		 3ko0K-2e8mA:
20.00
3ko0L-2e8mA:
20.00
3ko0M-2e8mA:
20.00
3ko0N-2e8mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 2e8m EPIDERMAL GROWTH
FACTOR RECEPTOR
KINASE SUBSTRATE 8
(Homo
sapiens) 		4 / 6 LEU A  64
SER A  66
PHE A  65
ILE A  86
 None
 0.99A 3ko0S-2e8mA:
undetectable		 3ko0S-2e8mA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2e8m EPIDERMAL GROWTH
FACTOR RECEPTOR
KINASE SUBSTRATE 8
(Homo
sapiens) 		3 / 4 ARG A  81
GLY A  79
GLU A  78
 None
 0.61A 4z2dB-2e8mA:
undetectable
4z2dC-2e8mA:
undetectable		 4z2dB-2e8mA:
14.65
4z2dC-2e8mA:
18.59