SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e8y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 8 LEU A  36
GLY A  88
ILE A  87
VAL A  75
ILE A  18
 None
 1.11A 1d4yB-2e8yA:
undetectable		 1d4yB-2e8yA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 10 LEU A 439
ASN A 368
VAL A 372
TRP A 437
LEU A 407
 None
 1.42A 1fkoA-2e8yA:
undetectable		 1fkoA-2e8yA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 11 ASN A 293
TYR A 288
GLY A 278
LEU A 271
TYR A 292
 None
 1.31A 1fkpA-2e8yA:
undetectable		 1fkpA-2e8yA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 6 LEU A 131
PHE A 117
TYR A 110
VAL A 153
 None
 1.22A 1ibgH-2e8yA:
3.2		 1ibgH-2e8yA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		7 / 12 TYR A 292
HIS A 340
ARG A 404
ASP A 406
GLU A 435
HIS A 524
ASP A 525
 None
 0.70A 1mxdA-2e8yA:
24.7		 1mxdA-2e8yA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 6 PRO A  66
MET A  15
ALA A  95
GLU A  99
 None
 1.28A 1qhyA-2e8yA:
undetectable		 1qhyA-2e8yA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 4 HIS A 524
ASP A 465
ASN A 474
ASP A 525
 None
 1.17A 1wg8A-2e8yA:
undetectable		 1wg8A-2e8yA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 7 LEU A  36
GLY A  88
ILE A  87
VAL A  75
ILE A  18
 None
 1.20A 2aojB-2e8yA:
undetectable		 2aojB-2e8yA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_1
(POL POLYPROTEIN)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 9 LEU A  36
GLY A  88
ILE A  87
VAL A  75
ILE A  18
 None
 1.10A 2avoA-2e8yA:
undetectable		 2avoA-2e8yA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 6 ARG A 380
ASN A 170
PRO A 122
ALA A 123
 None
 1.28A 2ejfB-2e8yA:
undetectable		 2ejfB-2e8yA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 6 LEU A 318
VAL A 273
MET A 321
ILE A 322
 None
 0.85A 2piwA-2e8yA:
undetectable		 2piwA-2e8yA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 7 LEU A 634
GLU A 632
ILE A 658
ALA A 615
 None
 0.79A 2xkwA-2e8yA:
undetectable		 2xkwA-2e8yA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 8 ARG A  92
GLY A 355
PRO A 354
GLU A 350
 None
 0.94A 2ys6A-2e8yA:
undetectable		 2ys6A-2e8yA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_A_C2FA401_0
(AMINOMETHYLTRANSFERA
SE)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 MET A  15
TYR A 356
ASP A  97
ILE A  91
VAL A  90
 None
 1.37A 3a8iA-2e8yA:
0.0		 3a8iA-2e8yA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_B_C2FB401_0
(AMINOMETHYLTRANSFERA
SE)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 MET A  15
TYR A 356
ASP A  97
ILE A  91
VAL A  90
 None
 1.37A 3a8iB-2e8yA:
4.0		 3a8iB-2e8yA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 MET A  15
TYR A 356
ASP A  97
ILE A  91
VAL A  90
 None
 1.38A 3a8iD-2e8yA:
0.0		 3a8iD-2e8yA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 ARG A 404
ASP A 406
GLU A 435
ARG A 468
HIS A 524
 None
 0.79A 3aicA-2e8yA:
2.3		 3aicA-2e8yA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 ARG A 404
ASP A 406
GLU A 435
HIS A 524
ASP A 525
 None
 0.73A 3aicA-2e8yA:
2.3		 3aicA-2e8yA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 ARG A 404
ASP A 406
GLU A 435
ARG A 468
HIS A 524
 None
 0.89A 3aicB-2e8yA:
5.8		 3aicB-2e8yA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 ARG A 404
ASP A 406
GLU A 435
HIS A 524
ASP A 525
 None
 0.76A 3aicB-2e8yA:
5.8		 3aicB-2e8yA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		6 / 12 ARG A 404
ASP A 406
GLU A 435
HIS A 524
ASP A 525
TYR A 292
 None
 0.74A 3aicC-2e8yA:
6.9		 3aicC-2e8yA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 ARG A 404
ASP A 406
GLU A 435
ARG A 468
HIS A 524
 None
 0.85A 3aicD-2e8yA:
6.9		 3aicD-2e8yA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 ARG A 404
ASP A 406
GLU A 435
HIS A 524
ASP A 525
 None
 0.81A 3aicD-2e8yA:
6.9		 3aicD-2e8yA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 ARG A 404
ASP A 406
GLU A 435
ARG A 468
HIS A 524
 None
 0.84A 3aicE-2e8yA:
6.9		 3aicE-2e8yA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 ARG A 404
ASP A 406
GLU A 435
HIS A 524
ASP A 525
 None
 0.76A 3aicE-2e8yA:
6.9		 3aicE-2e8yA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 ARG A 404
ASP A 406
GLU A 435
HIS A 524
ASP A 525
 None
 0.81A 3aicF-2e8yA:
6.9		 3aicF-2e8yA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 ARG A 404
ASP A 406
GLU A 435
HIS A 524
ASP A 525
 None
 0.76A 3aicG-2e8yA:
6.9		 3aicG-2e8yA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 ARG A 404
ASP A 406
GLU A 435
HIS A 524
ASP A 525
 None
 0.78A 3aicH-2e8yA:
6.9		 3aicH-2e8yA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KCX_A_CQLA1_0
(HYPOXIA-INDUCIBLE
FACTOR 1-ALPHA
INHIBITOR)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 10 TYR A 605
LEU A 609
THR A 705
HIS A 661
ILE A 707
 None
 1.33A 3kcxA-2e8yA:
undetectable		 3kcxA-2e8yA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		3 / 3 SER A 585
SER A 584
HIS A 221
 None
 0.85A 3mzeA-2e8yA:
undetectable		 3mzeA-2e8yA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		3 / 3 THR A 598
ASP A 592
GLU A 229
 None
 0.84A 3qowA-2e8yA:
undetectable		 3qowA-2e8yA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 GLY A 702
GLU A 540
LEU A 537
MET A 533
ALA A 484
 None
 1.05A 3t7vA-2e8yA:
4.5		 3t7vA-2e8yA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1003_1
(HEMOLYTIC LECTIN
CEL-III)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 4 ASP A 389
GLU A 105
GLY A 104
TYR A 181
 None
 1.42A 3w9tA-2e8yA:
0.0		 3w9tA-2e8yA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 5 ASP A 389
GLU A 105
GLY A 104
TYR A 181
 None
 1.34A 3w9tA-2e8yA:
undetectable		 3w9tA-2e8yA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB507_1
(HEMOLYTIC LECTIN
CEL-III)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 4 ASP A 389
GLU A 105
GLY A 104
TYR A 181
 None
 1.42A 3w9tB-2e8yA:
0.0		 3w9tB-2e8yA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 5 ASP A 389
GLU A 105
GLY A 104
TYR A 181
 None
 1.35A 3w9tC-2e8yA:
undetectable		 3w9tC-2e8yA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 5 ASP A 389
GLU A 105
GLY A 104
TYR A 181
 None
 1.41A 3w9tD-2e8yA:
undetectable		 3w9tD-2e8yA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 5 ASP A 389
GLU A 105
GLY A 104
TYR A 181
 None
 1.34A 3w9tD-2e8yA:
undetectable		 3w9tD-2e8yA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE503_1
(HEMOLYTIC LECTIN
CEL-III)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 4 ASP A 389
GLU A 105
GLY A 104
TYR A 181
 None
 1.41A 3w9tE-2e8yA:
0.0		 3w9tE-2e8yA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF502_1
(HEMOLYTIC LECTIN
CEL-III)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 4 ASP A 389
GLU A 105
GLY A 104
TYR A 181
 None
 1.42A 3w9tF-2e8yA:
0.0		 3w9tF-2e8yA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 5 ASP A 389
GLU A 105
GLY A 104
TYR A 181
 None
 1.34A 3w9tG-2e8yA:
undetectable		 3w9tG-2e8yA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		3 / 3 ASN A 399
TRP A 202
ASP A 401
 None
 0.89A 4a7tA-2e8yA:
undetectable
4a7tF-2e8yA:
3.7		 4a7tA-2e8yA:
15.55
4a7tF-2e8yA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFU_A_KANA401_1
(APH(2')-ID)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 SER A 523
ASP A 525
ASP A 465
GLU A 269
GLU A 219
 None
 1.21A 4dfuA-2e8yA:
0.1		 4dfuA-2e8yA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		6 / 10 LEU A  36
ASP A  14
GLY A  88
ILE A  87
VAL A  75
ILE A  18
 None
 1.25A 4dqfB-2e8yA:
undetectable		 4dqfB-2e8yA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 11 SER A  63
VAL A  75
ALA A  10
THR A  83
HIS A  73
 None
 1.19A 4e0fA-2e8yA:
2.4		 4e0fA-2e8yA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 7 TYR A 259
VAL A 260
LEU A 263
VAL A 216
 None
 1.01A 4e1gB-2e8yA:
undetectable		 4e1gB-2e8yA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 7 GLY A 561
VAL A 213
PRO A 563
ASN A 519
 None
 0.83A 4forA-2e8yA:
undetectable		 4forA-2e8yA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 6 PRO A 300
TYR A 239
TYR A 304
PHE A 276
 None
None
GOL  A 761 ( 4.9A)
None
 1.22A 4g10A-2e8yA:
undetectable		 4g10A-2e8yA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		6 / 12 LEU A  36
ASP A  14
GLY A  88
ILE A  87
VAL A  75
ILE A  18
 None
 1.20A 4jecA-2e8yA:
undetectable		 4jecA-2e8yA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 8 LEU A 645
TYR A 643
VAL A 706
THR A 705
 None
 0.90A 4ma7A-2e8yA:
undetectable		 4ma7A-2e8yA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 9 ASP A 224
PRO A 284
VAL A 279
ALA A 287
GLY A 237
 None
GOL  A 761 (-4.0A)
None
None
GOL  A 761 (-3.7A)
 1.31A 4mm5A-2e8yA:
undetectable		 4mm5A-2e8yA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM5_A_SREA603_1
(TRANSPORTER)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 9 PRO A 284
VAL A 279
ALA A 287
TYR A 288
GLY A 237
 GOL  A 761 (-4.0A)
None
None
None
GOL  A 761 (-3.7A)
 1.22A 4mm5A-2e8yA:
undetectable		 4mm5A-2e8yA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 9 ASP A 224
PRO A 284
VAL A 279
ALA A 287
TYR A 288
 None
GOL  A 761 (-4.0A)
None
None
None
 1.31A 4mmbA-2e8yA:
undetectable		 4mmbA-2e8yA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 9 ASP A 224
VAL A 279
ALA A 287
TYR A 288
GLY A 237
 None
None
None
None
GOL  A 761 (-3.7A)
 1.15A 4mmbA-2e8yA:
undetectable		 4mmbA-2e8yA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 7 ARG A 573
ILE A 606
LEU A 263
THR A 220
 None
 1.03A 4mmcA-2e8yA:
undetectable		 4mmcA-2e8yA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 PRO A 284
VAL A 279
ALA A 287
TYR A 288
GLY A 237
 GOL  A 761 (-4.0A)
None
None
None
GOL  A 761 (-3.7A)
 1.19A 4mmdB-2e8yA:
undetectable		 4mmdB-2e8yA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 5 ALA A 305
TYR A 304
HIS A 340
PHE A 276
 None
GOL  A 761 ( 4.9A)
None
None
 1.25A 4ze2A-2e8yA:
undetectable		 4ze2A-2e8yA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 6 ILE A 518
PHE A 564
ILE A 333
GLU A 269
 None
 1.31A 4zzcA-2e8yA:
undetectable
4zzcB-2e8yA:
undetectable		 4zzcA-2e8yA:
18.32
4zzcB-2e8yA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 6 ILE A 518
PHE A 564
ILE A 333
GLU A 269
 None
 1.29A 4zzcB-2e8yA:
undetectable
4zzcC-2e8yA:
undetectable		 4zzcB-2e8yA:
18.32
4zzcC-2e8yA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 ARG A 404
ASP A 406
GLU A 435
HIS A 524
ASP A 525
 None
 0.54A 5csyB-2e8yA:
19.4		 5csyB-2e8yA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 10 TYR A 605
VAL A 706
ILE A 707
LEU A 612
PHE A 687
 None
 1.32A 5hw8C-2e8yA:
undetectable
5hw8H-2e8yA:
undetectable		 5hw8C-2e8yA:
11.10
5hw8H-2e8yA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I6X_A_8PRA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 10 ALA A 559
ILE A 498
PHE A 467
GLY A 500
VAL A 471
 None
 1.16A 5i6xA-2e8yA:
undetectable		 5i6xA-2e8yA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		3 / 3 VAL A 562
GLU A 219
GLU A 269
 None
 0.91A 5jsdB-2e8yA:
undetectable
5jsdC-2e8yA:
undetectable		 5jsdB-2e8yA:
21.86
5jsdC-2e8yA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LUR_B_STRB201_1
(AVIDIN)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 11 HIS A 661
TYR A 643
VAL A 471
PHE A 467
PHE A 619
 None
 1.48A 5lurB-2e8yA:
3.1		 5lurB-2e8yA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 4 GLU A   9
PRO A  23
ILE A  22
LEU A  21
 None
 0.83A 5m45A-2e8yA:
undetectable		 5m45A-2e8yA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 4 GLU A   9
PRO A  23
ILE A  22
LEU A  21
 None
 0.89A 5m45D-2e8yA:
undetectable		 5m45D-2e8yA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 4 GLU A   9
PRO A  23
ILE A  22
LEU A  21
 None
 0.82A 5m45G-2e8yA:
undetectable		 5m45G-2e8yA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 4 GLU A   9
PRO A  23
ILE A  22
LEU A  21
 None
 0.92A 5m45J-2e8yA:
undetectable		 5m45J-2e8yA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		4 / 8 GLN A 560
GLY A 497
ILE A 555
GLN A 569
 None
 1.02A 5vlmH-2e8yA:
undetectable		 5vlmH-2e8yA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 TYR A 292
HIS A 340
ASP A 406
HIS A 524
ASP A 525
 None
 0.53A 6ag0A-2e8yA:
24.5		 6ag0A-2e8yA:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGG_D_84GD600_0
(BIFUNCTIONAL AAC/APH)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 11 ASN A 339
HIS A 340
TYR A 292
GLU A 435
GLU A 219
 None
 1.48A 6cggD-2e8yA:
1.1		 6cggD-2e8yA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 ASP A 666
ALA A 699
GLY A 704
GLY A 702
VAL A 706
 None
 1.24A 6clxA-2e8yA:
undetectable		 6clxA-2e8yA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A 432
ILE A 460
GLY A 461
ILE A 518
VAL A 336
 None
 0.91A 6emuA-2e8yA:
undetectable		 6emuA-2e8yA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		3 / 3 ARG A 381
LYS A 385
TYR A 418
 None
 1.28A 6gnaA-2e8yA:
undetectable		 6gnaA-2e8yA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		3 / 3 ARG A 381
LYS A 385
TYR A 418
 None
 1.28A 6gnbA-2e8yA:
undetectable		 6gnbA-2e8yA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 2e8y AMYX PROTEIN
(Bacillus
subtilis) 		5 / 12 LEU A 451
VAL A 511
THR A 441
GLY A 369
ASP A 465
 None
 1.04A 6gngA-2e8yA:
undetectable		 6gngA-2e8yA:
22.18