SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e9f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		3 / 3 MET A 249
LEU A 252
SER A 253
 None
 0.68A 1ee2A-2e9fA:
undetectable		 1ee2A-2e9fA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 7 GLU A  95
MET A  87
LEU A  82
GLU A  81
 None
 1.14A 1linA-2e9fA:
undetectable		 1linA-2e9fA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 5 ILE A 126
LEU A 133
ALA A 183
GLU A 187
 None
 0.98A 1xvaA-2e9fA:
undetectable
1xvaB-2e9fA:
undetectable		 1xvaA-2e9fA:
22.10
1xvaB-2e9fA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 6 ALA A 183
GLU A 187
ILE A 126
LEU A 133
 None
 1.03A 1xvaA-2e9fA:
undetectable
1xvaB-2e9fA:
undetectable		 1xvaA-2e9fA:
22.10
1xvaB-2e9fA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 8 THR A 106
LEU A  46
VAL A  49
GLY A  50
 None
 0.78A 2a1oA-2e9fA:
undetectable		 2a1oA-2e9fA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSE_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 5 PHE A 221
GLU A 218
ARG A 123
TRP A  37
 None
 1.40A 2nseA-2e9fA:
0.0
2nseB-2e9fA:
0.0		 2nseA-2e9fA:
22.68
2nseB-2e9fA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		5 / 9 ALA A 305
GLY A 300
LEU A 242
LEU A 245
ALA A 334
 None
 0.93A 2z0yB-2e9fA:
undetectable		 2z0yB-2e9fA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		3 / 3 ARG A 110
ASP A 117
ASP A  84
 None
 0.93A 3jb2A-2e9fA:
2.1		 3jb2A-2e9fA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		3 / 3 GLU A 329
LEU A 332
ASP A 333
 None
 0.28A 3ko0A-2e9fA:
0.9		 3ko0A-2e9fA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		3 / 3 GLU A 329
LEU A 332
ASP A 333
 None
 0.21A 3ko0T-2e9fA:
0.8		 3ko0T-2e9fA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 8 PHE A 269
TYR A 262
ALA A 363
THR A 368
 None
 0.93A 3l4dA-2e9fA:
undetectable		 3l4dA-2e9fA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLF_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 6 PHE A 221
GLU A 218
ARG A 123
TRP A  37
 None
 1.39A 3nlfA-2e9fA:
0.0
3nlfB-2e9fA:
0.0		 3nlfA-2e9fA:
22.68
3nlfB-2e9fA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		5 / 12 ALA A 299
LEU A 252
LEU A 342
ASN A 246
LEU A 245
 None
 1.00A 3r9cA-2e9fA:
undetectable		 3r9cA-2e9fA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 6 ARG A 123
TRP A  37
PHE A 221
GLU A 218
 None
 1.38A 3ufrA-2e9fA:
undetectable
3ufrB-2e9fA:
undetectable		 3ufrA-2e9fA:
20.24
3ufrB-2e9fA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 6 ARG A 123
TRP A  37
PHE A 221
GLU A 218
 None
 1.41A 4d33A-2e9fA:
0.0
4d33B-2e9fA:
0.0		 4d33A-2e9fA:
22.73
4d33B-2e9fA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 6 ASP A  35
ASP A  84
ARG A 110
GLU A  90
 None
 1.00A 4eysA-2e9fA:
undetectable		 4eysA-2e9fA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		5 / 12 ALA A 378
LEU A 428
LEU A 427
ALA A 387
GLU A 412
 None
 1.11A 4lg1A-2e9fA:
undetectable		 4lg1A-2e9fA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_B_SAMB301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		5 / 12 ALA A 378
LEU A 428
LEU A 427
ALA A 387
GLU A 412
 None
 1.14A 4lg1B-2e9fA:
undetectable		 4lg1B-2e9fA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 5 THR A 215
THR A 206
LEU A  51
LEU A  46
 None
 1.11A 4lvcB-2e9fA:
undetectable		 4lvcB-2e9fA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		5 / 9 ARG A 162
THR A 368
GLY A 365
LEU A 369
PRO A 165
 None
 1.42A 4mjrA-2e9fA:
0.0		 4mjrA-2e9fA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		3 / 3 PRO A 197
LEU A 198
HIS A 105
 None
 0.67A 4pevA-2e9fA:
undetectable		 4pevA-2e9fA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		5 / 11 LEU A 408
LEU A 428
LEU A 413
ALA A 374
LEU A 373
 None
 1.23A 4wg0H-2e9fA:
undetectable
4wg0I-2e9fA:
undetectable
4wg0J-2e9fA:
undetectable		 4wg0H-2e9fA:
2.94
4wg0I-2e9fA:
2.94
4wg0J-2e9fA:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 7 ARG A 123
TRP A  37
PHE A 221
GLU A 218
 None
 1.33A 5ad9A-2e9fA:
undetectable
5ad9B-2e9fA:
undetectable		 5ad9A-2e9fA:
20.24
5ad9B-2e9fA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 6 PHE A 221
GLU A 218
ARG A 123
TRP A  37
 None
 1.30A 5ad9A-2e9fA:
undetectable
5ad9B-2e9fA:
undetectable		 5ad9A-2e9fA:
20.24
5ad9B-2e9fA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADB_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 6 PHE A 221
GLU A 218
ARG A 123
TRP A  37
 None
 1.31A 5adbA-2e9fA:
undetectable
5adbB-2e9fA:
undetectable		 5adbA-2e9fA:
20.24
5adbB-2e9fA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		5 / 10 LEU A  46
ALA A  43
LEU A  57
GLY A  63
LEU A  64
 None
 1.30A 5dx3A-2e9fA:
undetectable		 5dx3A-2e9fA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		3 / 3 ASP A 236
VAL A 313
LEU A 309
 None
 0.67A 5e5jB-2e9fA:
undetectable		 5e5jB-2e9fA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 7 PHE A 221
GLU A 218
ARG A 123
TRP A  37
 None
 1.37A 5unuA-2e9fA:
1.1
5unuB-2e9fA:
undetectable		 5unuA-2e9fA:
20.24
5unuB-2e9fA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 7 PHE A 221
GLU A 218
ARG A 123
TRP A  37
 None
 1.37A 5unwA-2e9fA:
0.9
5unwB-2e9fA:
undetectable		 5unwA-2e9fA:
20.24
5unwB-2e9fA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 6 PHE A 221
GLU A 218
ARG A 123
TRP A  37
 None
 1.32A 5unxA-2e9fA:
0.9
5unxB-2e9fA:
undetectable		 5unxA-2e9fA:
20.24
5unxB-2e9fA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO5_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 7 PHE A 221
GLU A 218
ARG A 123
TRP A  37
 None
 1.38A 5uo5A-2e9fA:
undetectable
5uo5B-2e9fA:
undetectable		 5uo5A-2e9fA:
20.12
5uo5B-2e9fA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 7 PHE A 221
GLU A 218
ARG A 123
TRP A  37
 None
 1.37A 5uo7A-2e9fA:
undetectable
5uo7B-2e9fA:
undetectable		 5uo7A-2e9fA:
20.12
5uo7B-2e9fA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 6 ARG A 123
TRP A  37
PHE A 221
GLU A 218
 None
 1.37A 5uo8A-2e9fA:
undetectable
5uo8B-2e9fA:
0.0		 5uo8A-2e9fA:
22.12
5uo8B-2e9fA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO8_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 6 PHE A 221
GLU A 218
VAL A  41
ARG A 123
 None
 1.48A 5uo8A-2e9fA:
0.0
5uo8B-2e9fA:
0.0		 5uo8A-2e9fA:
22.12
5uo8B-2e9fA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO9_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 6 ARG A 123
TRP A  37
PHE A 221
GLU A 218
 None
 1.36A 5uo9C-2e9fA:
0.0
5uo9D-2e9fA:
0.0		 5uo9C-2e9fA:
22.12
5uo9D-2e9fA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVA_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 7 ARG A 123
TRP A  37
PHE A 221
GLU A 218
 None
 1.38A 5vvaA-2e9fA:
undetectable
5vvaB-2e9fA:
undetectable		 5vvaA-2e9fA:
22.73
5vvaB-2e9fA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVB_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 5 ARG A 123
TRP A  37
PHE A 221
GLU A 218
 None
 1.41A 5vvbA-2e9fA:
0.0
5vvbB-2e9fA:
0.0		 5vvbA-2e9fA:
22.12
5vvbB-2e9fA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVB_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 5 ARG A 123
TRP A  37
PHE A 221
GLU A 218
 None
 1.42A 5vvbC-2e9fA:
0.0
5vvbD-2e9fA:
0.0		 5vvbC-2e9fA:
22.12
5vvbD-2e9fA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV2_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 7 PHE A 221
GLU A 218
ARG A 123
TRP A  37
 None
 1.35A 6av2A-2e9fA:
undetectable
6av2B-2e9fA:
undetectable		 6av2A-2e9fA:
9.52
6av2B-2e9fA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_A_H4BA502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 7 ARG A 123
TRP A  37
PHE A 221
GLU A 218
 None
 1.39A 6av7A-2e9fA:
undetectable
6av7B-2e9fA:
undetectable		 6av7A-2e9fA:
11.49
6av7B-2e9fA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 6 PHE A 221
GLU A 218
ARG A 123
TRP A  37
 None
 1.36A 6av7A-2e9fA:
0.0
6av7B-2e9fA:
0.0		 6av7A-2e9fA:
11.49
6av7B-2e9fA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV7_C_H4BC502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 6 ARG A 123
TRP A  37
PHE A 221
GLU A 218
 None
 1.34A 6av7C-2e9fA:
0.0
6av7D-2e9fA:
0.0		 6av7C-2e9fA:
11.49
6av7D-2e9fA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_A_H4BA502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 6 ARG A 123
TRP A  37
PHE A 221
GLU A 218
 None
 1.39A 6cieA-2e9fA:
0.0
6cieB-2e9fA:
0.0		 6cieA-2e9fA:
11.49
6cieB-2e9fA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIE_C_H4BC502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 6 ARG A 123
TRP A  37
PHE A 221
GLU A 218
 None
 1.38A 6cieC-2e9fA:
0.0
6cieD-2e9fA:
0.0		 6cieC-2e9fA:
11.49
6cieD-2e9fA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_B_H4BB502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 6 PHE A 221
GLU A 218
ARG A 123
TRP A  37
 None
 1.36A 6cifA-2e9fA:
0.0
6cifB-2e9fA:
0.0		 6cifA-2e9fA:
11.49
6cifB-2e9fA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIF_D_H4BD502_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2e9f ARGININOSUCCINATE
LYASE
(Thermus
thermophilus) 		4 / 6 PHE A 221
GLU A 218
ARG A 123
TRP A  37
 None
 1.43A 6cifC-2e9fA:
0.0
6cifD-2e9fA:
0.0		 6cifC-2e9fA:
11.49
6cifD-2e9fA:
11.49