SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e9w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 2e9w MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		4 / 6 ILE A 235
ARG A 271
TRP A 246
VAL A 211
 None
 0.84A 1db1A-2e9wA:
undetectable		 1db1A-2e9wA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2e9w MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		6 / 12 LEU A 184
GLY A 150
GLY A 153
LEU A 196
LEU A 156
LEU A 160
 None
 1.47A 2nxeA-2e9wA:
undetectable		 2nxeA-2e9wA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2e9w MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		4 / 8 GLN A 256
LEU A 275
LEU A 305
GLY A 286
 None
 0.83A 2qqcH-2e9wA:
undetectable
2qqcK-2e9wA:
undetectable		 2qqcH-2e9wA:
12.39
2qqcK-2e9wA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 2e9w MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 12 THR A 391
PHE A 316
ASN A 314
VAL A 335
ILE A 313
 None
 1.23A 2vn0A-2e9wA:
undetectable		 2vn0A-2e9wA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2e9w MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		4 / 8 THR A 276
ASP A 284
GLU A 227
SER A 279
 None
 1.02A 2zw9A-2e9wA:
undetectable		 2zw9A-2e9wA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 2e9w MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		3 / 3 PRO A  61
ASN A  99
HIS A 101
 None
 0.86A 4ma3H-2e9wA:
9.6
4ma3L-2e9wA:
9.3		 4ma3H-2e9wA:
18.33
4ma3L-2e9wA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2e9w MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 12 ILE A 170
GLY A 169
PHE A 162
VAL A 134
ILE A 172
 None
 1.14A 4rvdA-2e9wA:
undetectable		 4rvdA-2e9wA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2e9w MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
(Homo
sapiens) 		5 / 12 ILE A 170
GLY A 169
PHE A 162
VAL A 134
ILE A 172
 None
 1.15A 4rvgA-2e9wA:
undetectable		 4rvgA-2e9wA:
21.26