SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e9x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2e9x DNA REPLICATION
COMPLEX GINS PROTEIN
PSF1
(Homo
sapiens) 		3 / 3 LEU A  98
PRO A  99
LEU A 102
 None
SO4  A1003 (-4.3A)
None
 0.53A 1hrkA-2e9xA:
undetectable		 1hrkA-2e9xA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 2e9x DNA REPLICATION
COMPLEX GINS PROTEIN
PSF1
(Homo
sapiens) 		3 / 3 ASP A  82
TYR A  79
GLU A 110
 None
 0.85A 1vm1A-2e9xA:
undetectable		 1vm1A-2e9xA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2e9x DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2
(Homo
sapiens) 		5 / 12 ILE B  26
GLY B  34
LEU B  40
PRO B  19
ILE B  18
 None
 1.20A 1zq9A-2e9xB:
undetectable		 1zq9A-2e9xB:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 2e9x DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2
(Homo
sapiens) 		4 / 7 LEU B  23
ILE B  18
ILE B  17
VAL B  42
 None
 0.86A 4ojbA-2e9xB:
undetectable		 4ojbA-2e9xB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 2e9x DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2
(Homo
sapiens) 		5 / 11 LEU B  48
VAL B  15
LEU B  60
LEU B  33
LEU B  52
 None
 1.32A 4or0B-2e9xB:
undetectable		 4or0B-2e9xB:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2e9x DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2
(Homo
sapiens) 		4 / 5 TYR B  92
LEU B  95
GLU B  94
TYR B  91
 None
 1.47A 4z4dA-2e9xB:
0.0		 4z4dA-2e9xB:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 2e9x DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2
(Homo
sapiens) 		3 / 3 PRO B  19
LEU B  33
SER B  22
 None
 0.79A 5fsaB-2e9xB:
undetectable		 5fsaB-2e9xB:
17.45