SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2e9y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2e9y CARBAMATE KINASE
(Aeropyrum
pernix) 		5 / 12 VAL A 210
GLY A  60
THR A  82
ALA A  81
LEU A  62
 None
 1.09A 1jg4A-2e9yA:
3.7		 1jg4A-2e9yA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 2e9y CARBAMATE KINASE
(Aeropyrum
pernix) 		5 / 10 LEU A 178
ALA A 191
GLY A 195
GLY A 196
ILE A 179
 None
 0.96A 1sdvA-2e9yA:
undetectable		 1sdvA-2e9yA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 2e9y CARBAMATE KINASE
(Aeropyrum
pernix) 		5 / 12 GLY A  56
GLY A  13
VAL A 213
VAL A  59
LEU A  78
 None
 1.02A 1vptA-2e9yA:
2.5		 1vptA-2e9yA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 2e9y CARBAMATE KINASE
(Aeropyrum
pernix) 		5 / 12 LEU A 178
ALA A 191
GLY A 195
GLY A 196
VAL A 197
 None
 0.85A 2avsA-2e9yA:
undetectable		 2avsA-2e9yA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 2e9y CARBAMATE KINASE
(Aeropyrum
pernix) 		4 / 6 ALA A 257
ILE A 283
VAL A 286
GLU A 287
 None
 0.75A 2cizA-2e9yA:
undetectable		 2cizA-2e9yA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 2e9y CARBAMATE KINASE
(Aeropyrum
pernix) 		4 / 8 VAL A 241
VAL A 279
LEU A 253
TYR A 264
 None
 1.02A 2ddwA-2e9yA:
undetectable		 2ddwA-2e9yA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 2e9y CARBAMATE KINASE
(Aeropyrum
pernix) 		5 / 12 ALA A  15
GLN A  28
GLY A  90
LEU A  91
LEU A  11
 None
 1.32A 2nv4A-2e9yA:
undetectable		 2nv4A-2e9yA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 2e9y CARBAMATE KINASE
(Aeropyrum
pernix) 		5 / 12 ALA A  15
GLN A  28
GLY A  90
LEU A  91
LEU A  11
 None
 1.37A 2nv4B-2e9yA:
undetectable		 2nv4B-2e9yA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_1
(PHOSPHOLIPASE A2)		 2e9y CARBAMATE KINASE
(Aeropyrum
pernix) 		4 / 4 SER A 125
PRO A 124
PHE A 126
PRO A 168
 None
 1.48A 3bjwA-2e9yA:
0.0		 3bjwA-2e9yA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 2e9y CARBAMATE KINASE
(Aeropyrum
pernix) 		5 / 8 ALA A 219
ASP A 217
ASP A 215
GLY A  54
VAL A 197
 None
 1.44A 3em6A-2e9yA:
undetectable		 3em6A-2e9yA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_1
(HIV-1 PROTEASE)		 2e9y CARBAMATE KINASE
(Aeropyrum
pernix) 		5 / 9 LEU A 178
ALA A 191
GLY A 196
VAL A 197
ILE A 179
 None
 0.97A 3oxvA-2e9yA:
undetectable		 3oxvA-2e9yA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2e9y CARBAMATE KINASE
(Aeropyrum
pernix) 		4 / 8 ILE A  16
GLY A  13
VAL A 190
SER A  49
 None
 0.87A 4acbB-2e9yA:
undetectable
4acbC-2e9yA:
2.1		 4acbB-2e9yA:
21.03
4acbC-2e9yA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2e9y CARBAMATE KINASE
(Aeropyrum
pernix) 		5 / 7 LEU A 223
ALA A 229
ASP A 230
VAL A 233
THR A  52
 None
 1.13A 4eyrA-2e9yA:
undetectable		 4eyrA-2e9yA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 2e9y CARBAMATE KINASE
(Aeropyrum
pernix) 		5 / 11 ASP A 217
VAL A 313
ALA A 258
SER A 284
THR A 311
 None
 1.31A 4mmaA-2e9yA:
undetectable		 4mmaA-2e9yA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 2e9y CARBAMATE KINASE
(Aeropyrum
pernix) 		5 / 12 GLY A 196
GLN A  86
LEU A 232
GLY A 296
THR A 236
 None
 1.13A 5fsaB-2e9yA:
undetectable		 5fsaB-2e9yA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 2e9y CARBAMATE KINASE
(Aeropyrum
pernix) 		3 / 3 TYR A  61
SER A  63
TRP A  88
 None
 0.92A 5n8jB-2e9yA:
undetectable		 5n8jB-2e9yA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 2e9y CARBAMATE KINASE
(Aeropyrum
pernix) 		3 / 3 TYR A  61
SER A  63
TRP A  88
 None
 0.91A 5n8jA-2e9yA:
undetectable		 5n8jA-2e9yA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 2e9y CARBAMATE KINASE
(Aeropyrum
pernix) 		3 / 3 TYR A  61
SER A  63
TRP A  88
 None
 0.97A 5n8jD-2e9yA:
undetectable		 5n8jD-2e9yA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 2e9y CARBAMATE KINASE
(Aeropyrum
pernix) 		5 / 10 PRO A 170
ILE A 179
LEU A 222
VAL A 117
LEU A 118
 None
 1.48A 5tixB-2e9yA:
2.6		 5tixB-2e9yA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 2e9y CARBAMATE KINASE
(Aeropyrum
pernix) 		5 / 7 GLY A 193
GLY A 194
GLY A  54
GLY A  13
GLY A  12
 None
 1.05A 6ag0A-2e9yA:
undetectable		 6ag0A-2e9yA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2e9y CARBAMATE KINASE
(Aeropyrum
pernix) 		5 / 10 ALA A 258
LEU A 261
VAL A 313
VAL A 241
ILE A 234
 None
 1.28A 6h1lA-2e9yA:
undetectable		 6h1lA-2e9yA:
21.98