SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ea1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 2ea1 RIBONUCLEASE I
(Escherichia
coli) 		3 / 3 GLN A   4
TYR A  14
ARG A  13
 None
 0.63A 1gtbA-2ea1A:
undetectable		 1gtbA-2ea1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2ea1 RIBONUCLEASE I
(Escherichia
coli) 		3 / 3 THR A 108
LEU A 112
VAL A 115
 None
 0.55A 1mz9E-2ea1A:
undetectable		 1mz9E-2ea1A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2ea1 RIBONUCLEASE I
(Escherichia
coli) 		4 / 7 LEU A 164
ALA A 160
PHE A 181
PHE A 177
 None
 1.03A 2vcvL-2ea1A:
undetectable		 2vcvL-2ea1A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 2ea1 RIBONUCLEASE I
(Escherichia
coli) 		3 / 3 TRP A  20
GLN A  28
THR A 205
 None
 0.95A 4m2xA-2ea1A:
undetectable		 4m2xA-2ea1A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2ea1 RIBONUCLEASE I
(Escherichia
coli) 		4 / 8 GLU A 206
GLN A 208
ILE A 209
LEU A  18
 None
GPG  A 250 (-2.6A)
None
None
 0.87A 4mj8A-2ea1A:
undetectable		 4mj8A-2ea1A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)		 2ea1 RIBONUCLEASE I
(Escherichia
coli) 		4 / 6 MET A 116
THR A  53
MET A 148
LEU A 164
 None
 1.19A 6mvxA-2ea1A:
undetectable
6mvxB-2ea1A:
undetectable
6mvxC-2ea1A:
undetectable		 6mvxA-2ea1A:
18.31
6mvxB-2ea1A:
18.31
6mvxC-2ea1A:
18.31