SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ea3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2ea3 CHYMOTRYPSIN
(Cellulomonas
bogoriensis) 		3 / 3 GLU A 119
TYR A 117
PHE A  52
 None
 0.64A 1eqbB-2ea3A:
undetectable		 1eqbB-2ea3A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2ea3 CHYMOTRYPSIN
(Cellulomonas
bogoriensis) 		3 / 3 GLU A 119
TYR A 117
PHE A  52
 None
 0.64A 1eqbA-2ea3A:
undetectable		 1eqbA-2ea3A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2ea3 CHYMOTRYPSIN
(Cellulomonas
bogoriensis) 		3 / 3 GLU A 119
TYR A 117
PHE A  52
 None
 0.64A 1eqbD-2ea3A:
undetectable		 1eqbD-2ea3A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2ea3 CHYMOTRYPSIN
(Cellulomonas
bogoriensis) 		3 / 3 GLU A 119
TYR A 117
PHE A  52
 None
 0.66A 1eqbC-2ea3A:
undetectable		 1eqbC-2ea3A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2ea3 CHYMOTRYPSIN
(Cellulomonas
bogoriensis) 		4 / 8 ASP A  56
PHE A  52
SER A 137
ALA A  58
 None
 0.89A 1rqpC-2ea3A:
undetectable		 1rqpC-2ea3A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 2ea3 CHYMOTRYPSIN
(Cellulomonas
bogoriensis) 		4 / 8 ASP A  56
PHE A  52
SER A 137
ALA A  58
 None
 0.88A 1rqpA-2ea3A:
undetectable		 1rqpA-2ea3A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 2ea3 CHYMOTRYPSIN
(Cellulomonas
bogoriensis) 		5 / 9 ASN A  24
ILE A 181
ILE A  28
GLY A  26
ALA A  22
 None
 1.32A 2dtjA-2ea3A:
undetectable
2dtjB-2ea3A:
undetectable		 2dtjA-2ea3A:
18.91
2dtjB-2ea3A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 2ea3 CHYMOTRYPSIN
(Cellulomonas
bogoriensis) 		4 / 8 ASP A  56
PHE A  52
SER A 137
ALA A  58
 None
 0.89A 2v7uA-2ea3A:
undetectable		 2v7uA-2ea3A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2ea3 CHYMOTRYPSIN
(Cellulomonas
bogoriensis) 		5 / 12 GLN A 167
ILE A 108
GLY A 149
ALA A  87
ALA A  88
 None
 0.99A 3sueA-2ea3A:
11.9		 3sueA-2ea3A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2ea3 CHYMOTRYPSIN
(Cellulomonas
bogoriensis) 		5 / 12 GLY A 149
VAL A  72
VAL A  94
ALA A 143
LEU A 142
 None
 0.83A 5kocA-2ea3A:
undetectable		 5kocA-2ea3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 2ea3 CHYMOTRYPSIN
(Cellulomonas
bogoriensis) 		5 / 12 GLY A 149
VAL A  72
VAL A  94
ALA A 143
LEU A 142
 None
 0.84A 5kpcA-2ea3A:
undetectable		 5kpcA-2ea3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2ea3 CHYMOTRYPSIN
(Cellulomonas
bogoriensis) 		3 / 3 PHE A 166
ASP A  56
LEU A 178
 None
 0.79A 5uhbC-2ea3A:
undetectable		 5uhbC-2ea3A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2ea3 CHYMOTRYPSIN
(Cellulomonas
bogoriensis) 		3 / 3 PHE A 166
ASP A  56
LEU A 178
 None
 0.76A 5uhcC-2ea3A:
undetectable		 5uhcC-2ea3A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 2ea3 CHYMOTRYPSIN
(Cellulomonas
bogoriensis) 		4 / 5 ALA A   8
SER A  18
GLY A  98
TYR A  75
 None
 1.24A 5yodB-2ea3A:
10.6		 5yodB-2ea3A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 2ea3 CHYMOTRYPSIN
(Cellulomonas
bogoriensis) 		4 / 5 ALA A   8
SER A  18
GLY A  98
TYR A  75
 None
 1.15A 5yodD-2ea3A:
6.6		 5yodD-2ea3A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 2ea3 CHYMOTRYPSIN
(Cellulomonas
bogoriensis) 		5 / 12 GLN A 167
ILE A 108
GLY A 149
ALA A  87
ALA A  88
 None
 0.90A 6c2mD-2ea3A:
4.7		 6c2mD-2ea3A:
19.55