SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eaa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		4 / 8 ASP A 370
HIS A 403
GLY A 368
GLY A 367
 None
 0.80A 1ekjA-2eaaA:
undetectable
1ekjB-2eaaA:
undetectable		 1ekjA-2eaaA:
19.68
1ekjB-2eaaA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		4 / 7 ASP A 370
HIS A 403
GLY A 368
GLY A 367
 None
 0.81A 1ekjE-2eaaA:
undetectable
1ekjF-2eaaA:
undetectable		 1ekjE-2eaaA:
19.68
1ekjF-2eaaA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		4 / 8 ASP A 370
HIS A 403
GLY A 368
GLY A 367
 None
 0.82A 1ekjG-2eaaA:
undetectable
1ekjH-2eaaA:
undetectable		 1ekjG-2eaaA:
19.68
1ekjH-2eaaA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		4 / 8 LEU A 131
ILE A 133
LEU A  93
ILE A  92
 None
 0.87A 2azxA-2eaaA:
undetectable		 2azxA-2eaaA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		5 / 12 LEU A 278
LEU A 277
ILE A 299
ALA A 297
THR A 345
 None
 1.08A 2v0mC-2eaaA:
undetectable		 2v0mC-2eaaA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		3 / 3 PHE A  22
ASN A  20
PHE A 332
 None
 0.99A 2zbuD-2eaaA:
undetectable		 2zbuD-2eaaA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		5 / 10 VAL A 270
ASP A 271
LEU A 326
ARG A 236
LEU A  87
 None
 1.45A 3j6gB-2eaaA:
undetectable		 3j6gB-2eaaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		5 / 10 VAL A 270
ASP A 271
LEU A 326
ARG A 236
LEU A  87
 None
 1.46A 3j6gD-2eaaA:
undetectable		 3j6gD-2eaaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		5 / 10 VAL A 270
ASP A 271
LEU A 326
ARG A 236
LEU A  87
 None
 1.46A 3j6gF-2eaaA:
undetectable		 3j6gF-2eaaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		5 / 10 VAL A 270
ASP A 271
LEU A 326
ARG A 236
LEU A  87
 None
 1.46A 3j6gH-2eaaA:
undetectable		 3j6gH-2eaaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		5 / 10 VAL A 270
ASP A 271
LEU A 326
ARG A 236
LEU A  87
 None
 1.46A 3j6gJ-2eaaA:
undetectable		 3j6gJ-2eaaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		5 / 10 VAL A 270
ASP A 271
LEU A 326
ARG A 236
LEU A  87
 None
 1.46A 3j6gL-2eaaA:
undetectable		 3j6gL-2eaaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		5 / 10 VAL A 270
ASP A 271
LEU A 326
ARG A 236
LEU A  87
 None
 1.46A 3j6gN-2eaaA:
undetectable		 3j6gN-2eaaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		5 / 10 VAL A 270
ASP A 271
LEU A 326
ARG A 236
LEU A  87
 None
 1.46A 3j6gP-2eaaA:
undetectable		 3j6gP-2eaaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		5 / 10 VAL A 270
ASP A 271
LEU A 326
ARG A 236
LEU A  87
 None
 1.46A 3j6gR-2eaaA:
undetectable		 3j6gR-2eaaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		5 / 10 ILE A 114
PHE A 120
ILE A 133
LEU A  73
HIS A  76
 None
 1.29A 3o1xA-2eaaA:
undetectable		 3o1xA-2eaaA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		3 / 4 SER A  51
GLY A 303
GLU A 318
 None
 0.66A 3raeA-2eaaA:
undetectable
3raeC-2eaaA:
undetectable		 3raeA-2eaaA:
22.26
3raeC-2eaaA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		3 / 3 ASN A 360
ALA A 357
LYS A 285
 None
 1.03A 3runA-2eaaA:
undetectable		 3runA-2eaaA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		3 / 3 SER A 100
ASP A 230
ASP A 262
 None
 0.91A 3uj7A-2eaaA:
undetectable		 3uj7A-2eaaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		4 / 7 PHE A  47
TYR A  60
VAL A  62
ILE A 134
 None
 0.89A 4a97E-2eaaA:
undetectable		 4a97E-2eaaA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_D_ZPCD1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		4 / 8 PHE A  47
TYR A  60
VAL A  62
ILE A 134
 None
 0.88A 4a97C-2eaaA:
undetectable		 4a97C-2eaaA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		4 / 8 PHE A  47
TYR A  60
VAL A  62
ILE A 134
 None
 0.89A 4a97D-2eaaA:
undetectable		 4a97D-2eaaA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		4 / 8 PHE A  47
TYR A  60
VAL A  62
ILE A 134
 None
 0.89A 4a97G-2eaaA:
undetectable		 4a97G-2eaaA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		4 / 7 PHE A  47
TYR A  60
VAL A  62
ILE A 134
 None
 0.86A 4a97H-2eaaA:
undetectable		 4a97H-2eaaA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		4 / 8 PHE A  47
TYR A  60
VAL A  62
ILE A 134
 None
 0.89A 4a97I-2eaaA:
undetectable		 4a97I-2eaaA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		4 / 8 GLY A 368
GLN A 399
SER A 374
ASN A 371
 None
 1.03A 4wrzA-2eaaA:
undetectable		 4wrzA-2eaaA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		4 / 7 GLY A 368
GLN A 399
SER A 374
ASN A 371
 None
 1.14A 4ws0A-2eaaA:
undetectable		 4ws0A-2eaaA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		4 / 6 ASP A 306
PRO A 335
TYR A 322
LEU A 301
 None
 1.35A 5bmvB-2eaaA:
undetectable		 5bmvB-2eaaA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		3 / 3 PHE A 351
ILE A 134
ASP A 330
 None
 0.72A 5cswA-2eaaA:
undetectable		 5cswA-2eaaA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		3 / 3 PHE A 351
ILE A 134
ASP A 330
 None
 0.72A 5cswB-2eaaA:
undetectable		 5cswB-2eaaA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		4 / 5 GLN A 212
HIS A 217
ILE A 211
ILE A  92
 None
 1.27A 5dnuA-2eaaA:
undetectable		 5dnuA-2eaaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		4 / 5 GLN A 212
HIS A 217
ILE A 211
ILE A  92
 None
 1.20A 5dnvA-2eaaA:
undetectable		 5dnvA-2eaaA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		5 / 7 GLY A  39
SER A  67
PHE A  65
LEU A  41
GLU A 199
 None
 1.35A 5izfA-2eaaA:
undetectable		 5izfA-2eaaA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		4 / 6 ILE A 211
ILE A 133
LEU A 106
PHE A  82
 None
 0.97A 5vkqB-2eaaA:
undetectable
5vkqC-2eaaA:
undetectable		 5vkqB-2eaaA:
13.14
5vkqC-2eaaA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		4 / 6 ILE A 211
ILE A 133
LEU A 106
PHE A  82
 None
 0.95A 5vkqC-2eaaA:
undetectable
5vkqD-2eaaA:
undetectable		 5vkqC-2eaaA:
13.14
5vkqD-2eaaA:
13.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CB4_A_BEZA501_0
(CANAVALIN)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		5 / 8 HIS A 281
ASN A 283
VAL A 288
ILE A 334
ARG A 362
 ACY  A 460 (-4.0A)
ACY  A 460 (-3.1A)
None
ACY  A 460 (-4.7A)
ACY  A 460 (-4.5A)
 0.36A 6cb4A-2eaaA:
47.5		 6cb4A-2eaaA:
51.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		3 / 3 GLN A  37
TYR A  38
ASN A  36
 None
 0.94A 6dwdC-2eaaA:
undetectable		 6dwdC-2eaaA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 2eaa 7S GLOBULIN-3
(Vigna
angularis) 		3 / 3 LEU A 106
GLY A 109
PHE A 353
 None
 0.61A 6exiC-2eaaA:
undetectable		 6exiC-2eaaA:
10.44