SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eaq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2eaq LIM DOMAIN ONLY
PROTEIN 7
(Homo
sapiens) 		5 / 12 ALA A1069
LEU A1082
PHE A1057
ILE A1091
LEU A1117
 None
 1.18A 1dreA-2eaqA:
undetectable		 1dreA-2eaqA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 2eaq LIM DOMAIN ONLY
PROTEIN 7
(Homo
sapiens) 		4 / 6 GLY A1065
ILE A1066
GLU A1087
ILE A1089
 None
 0.92A 3a7eA-2eaqA:
undetectable		 3a7eA-2eaqA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 2eaq LIM DOMAIN ONLY
PROTEIN 7
(Homo
sapiens) 		5 / 12 ILE A1045
SER A1080
ALA A1077
GLU A1072
ASP A1054
 None
 1.22A 6n91A-2eaqA:
undetectable		 6n91A-2eaqA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 2eaq LIM DOMAIN ONLY
PROTEIN 7
(Homo
sapiens) 		5 / 12 ILE A1045
SER A1080
ALA A1077
GLU A1072
ASP A1054
 None
 1.22A 6n91B-2eaqA:
undetectable		 6n91B-2eaqA:
20.22