SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eax'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2eax PEPTIDOGLYCAN
RECOGNITION
PROTEIN-I-BETA
(Homo
sapiens) 		4 / 8 LEU A 345
ILE A 330
ILE A 238
ILE A 307
 None
 0.81A 2bu8A-2eaxA:
undetectable		 2bu8A-2eaxA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 2eax PEPTIDOGLYCAN
RECOGNITION
PROTEIN-I-BETA
(Homo
sapiens) 		3 / 3 ARG A 253
ASP A 258
ASP A 265
 None
 0.89A 2ejtA-2eaxA:
undetectable		 2ejtA-2eaxA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2eax PEPTIDOGLYCAN
RECOGNITION
PROTEIN-I-BETA
(Homo
sapiens) 		3 / 3 ARG A 216
GLU A 223
THR A 224
 None
 0.84A 3v4tA-2eaxA:
undetectable		 3v4tA-2eaxA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 2eax PEPTIDOGLYCAN
RECOGNITION
PROTEIN-I-BETA
(Homo
sapiens) 		5 / 12 TYR A 300
GLY A 236
ALA A 304
LEU A 344
VAL A 346
 None
 1.28A 4azsA-2eaxA:
undetectable		 4azsA-2eaxA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 2eax PEPTIDOGLYCAN
RECOGNITION
PROTEIN-I-BETA
(Homo
sapiens) 		5 / 12 TYR A 300
GLY A 236
ALA A 304
LEU A 344
ILE A 365
 None
 1.09A 4aztA-2eaxA:
undetectable		 4aztA-2eaxA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM0_B_KANB302_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2eax PEPTIDOGLYCAN
RECOGNITION
PROTEIN-I-BETA
(Homo
sapiens) 		5 / 11 TYR A 274
LEU A 277
THR A 308
LEU A 255
ARG A 244
 None
 1.48A 4em0B-2eaxA:
0.0		 4em0B-2eaxA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2eax PEPTIDOGLYCAN
RECOGNITION
PROTEIN-I-BETA
(Homo
sapiens) 		5 / 11 ASP A 265
ILE A 264
SER A 269
TYR A 263
ASP A 258
 None
 1.48A 4rtrA-2eaxA:
undetectable		 4rtrA-2eaxA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2eax PEPTIDOGLYCAN
RECOGNITION
PROTEIN-I-BETA
(Homo
sapiens) 		4 / 8 ILE A 307
GLY A 289
LEU A 231
MET A 229
 None
 0.85A 5esjA-2eaxA:
undetectable		 5esjA-2eaxA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2eax PEPTIDOGLYCAN
RECOGNITION
PROTEIN-I-BETA
(Homo
sapiens) 		4 / 6 ARG A 222
ARG A 216
THR A 224
ILE A 264
 None
 1.46A 5ih0A-2eaxA:
undetectable		 5ih0A-2eaxA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 2eax PEPTIDOGLYCAN
RECOGNITION
PROTEIN-I-BETA
(Homo
sapiens) 		4 / 6 ILE A 307
ALA A 326
LEU A 329
ILE A 284
 None
 0.64A 5mvmB-2eaxA:
undetectable
5mvmC-2eaxA:
undetectable		 5mvmB-2eaxA:
18.29
5mvmC-2eaxA:
18.29