SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eb0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 10 VAL A 149
ILE A 256
GLY A 260
PRO A 154
THR A 155
 None
 1.09A 1k6cA-2eb0A:
undetectable		 1k6cA-2eb0A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ALA A  22
ILE A  63
GLY A 127
ILE A 122
 None
 0.70A 1sh9A-2eb0A:
undetectable		 1sh9A-2eb0A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		3 / 3 GLU A 281
GLU A 273
LEU A 287
 None
 0.59A 1v8bA-2eb0A:
2.7		 1v8bA-2eb0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		3 / 3 GLU A 281
GLU A 273
LEU A 287
 None
 0.58A 1v8bB-2eb0A:
2.9		 1v8bB-2eb0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 12 ALA A 263
VAL A 297
ILE A 215
GLY A 216
VAL A 218
 None
 0.86A 2avsA-2eb0A:
undetectable		 2avsA-2eb0A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 12 HIS A  88
SER A 108
PRO A 154
THR A 148
LEU A 252
 MN  A 502 (-3.6A)
None
None
None
None
 1.49A 2fj1A-2eb0A:
0.3		 2fj1A-2eb0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 10 SER A 108
ILE A 144
ILE A 145
LEU A 141
VAL A  42
 None
 1.07A 2nnhB-2eb0A:
1.4		 2nnhB-2eb0A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 5 LEU A 141
ASP A 160
ALA A 114
PHE A 151
 None
 1.04A 2opxA-2eb0A:
undetectable		 2opxA-2eb0A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 12 HIS A  88
ASP A  87
SER A 146
ASP A 147
ASP A  13
 MN  A 502 (-3.6A)
None
None
MN  A 502 (-2.6A)
MN  A 502 (-3.2A)
 1.44A 2pgfA-2eb0A:
undetectable		 2pgfA-2eb0A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6H_B_MXDB551_1
(PROSTACYCLIN
SYNTHASE)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ALA A 164
LEU A 167
ALA A 110
THR A 109
 None
 0.91A 3b6hB-2eb0A:
undetectable		 3b6hB-2eb0A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 5 HIS A  88
HIS A  89
ASP A 147
ASP A  11
 MN  A 502 (-3.6A)
None
MN  A 502 (-2.6A)
MN  A 501 (-2.5A)
 1.05A 3c0zA-2eb0A:
undetectable		 3c0zA-2eb0A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A  88
HIS A  89
ASP A 147
ASP A  11
 MN  A 502 (-3.6A)
None
MN  A 502 (-2.6A)
MN  A 501 (-2.5A)
 1.06A 3c0zC-2eb0A:
undetectable		 3c0zC-2eb0A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 9 VAL A 149
ILE A 256
GLY A 260
PRO A 154
THR A 155
 None
 1.08A 3el4B-2eb0A:
undetectable		 3el4B-2eb0A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 10 VAL A 149
ILE A 256
GLY A 260
PRO A 154
THR A 155
 None
 1.13A 3el5A-2eb0A:
undetectable		 3el5A-2eb0A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA A 186
VAL A  42
ILE A 145
LEU A 141
PHE A 179
 None
 1.46A 3fl9D-2eb0A:
undetectable		 3fl9D-2eb0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 6 VAL A   4
ILE A 113
ILE A  63
LEU A  64
 None
 0.82A 3hegA-2eb0A:
undetectable		 3hegA-2eb0A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_B_URFB521_1
(RNA DEPENDENT RNA
POLYMERASE)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 4 ARG A 293
ASP A 147
ASP A  11
ASP A  66
 None
MN  A 502 (-2.6A)
MN  A 501 (-2.5A)
MN  A 502 ( 2.6A)
 1.46A 3naiB-2eb0A:
1.4		 3naiB-2eb0A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 149
ILE A 256
GLY A 260
PRO A 154
THR A 155
 None
 1.02A 3spkB-2eb0A:
undetectable		 3spkB-2eb0A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 8 LYS A  45
ILE A 173
GLY A 180
ILE A 183
 None
 0.74A 3wxoA-2eb0A:
undetectable		 3wxoA-2eb0A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A 147
ASN A  36
ASP A 202
GLU A 219
 MN  A 502 (-2.6A)
None
None
None
 1.22A 4gkhJ-2eb0A:
undetectable		 4gkhJ-2eb0A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ALA A  22
GLY A 127
ILE A 122
VAL A  65
VAL A   4
 None
 1.07A 4j5jB-2eb0A:
undetectable		 4j5jB-2eb0A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 8 LYS A 294
SER A 292
SER A 153
ASP A  13
 None
None
None
MN  A 502 (-3.2A)
 1.19A 4kttC-2eb0A:
undetectable		 4kttC-2eb0A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 149
ILE A 256
GLY A 260
PRO A 154
THR A 155
 None
 1.05A 4njuA-2eb0A:
undetectable		 4njuA-2eb0A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 149
ILE A 256
GLY A 260
PRO A 154
THR A 155
 None
 1.04A 4njuC-2eb0A:
undetectable		 4njuC-2eb0A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ASP A  66
ASP A  13
GLU A  38
ILE A 183
 MN  A 502 ( 2.6A)
MN  A 502 (-3.2A)
None
None
 1.00A 4xjeA-2eb0A:
2.3		 4xjeA-2eb0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ASP A  66
ASP A  13
GLU A  38
ILE A 183
 MN  A 502 ( 2.6A)
MN  A 502 (-3.2A)
None
None
 0.97A 5cfsA-2eb0A:
undetectable		 5cfsA-2eb0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		3 / 3 PHE A  41
ILE A 183
ASP A  11
 None
None
MN  A 501 (-2.5A)
 0.59A 5cswA-2eb0A:
undetectable		 5cswA-2eb0A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		3 / 3 PHE A  41
ILE A 183
ASP A  13
 None
None
MN  A 502 (-3.2A)
 0.73A 5cswA-2eb0A:
undetectable		 5cswA-2eb0A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		3 / 3 PHE A  41
ILE A 183
ASP A  11
 None
None
MN  A 501 (-2.5A)
 0.59A 5cswB-2eb0A:
1.2		 5cswB-2eb0A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		3 / 3 PHE A  41
ILE A 183
ASP A  13
 None
None
MN  A 502 (-3.2A)
 0.65A 5cswB-2eb0A:
1.2		 5cswB-2eb0A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		6 / 9 LEU A 167
ASP A 135
LEU A 139
GLY A 138
LEU A 140
ALA A  16
 None
 1.48A 5dqfA-2eb0A:
undetectable		 5dqfA-2eb0A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 12 SER A 228
GLY A 191
LYS A 187
ASP A 222
ILE A 221
 None
 0.99A 5ekxA-2eb0A:
undetectable		 5ekxA-2eb0A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 8 ILE A  63
VAL A   4
VAL A  42
ILE A 183
ILE A 144
 None
 1.39A 5hi2A-2eb0A:
undetectable		 5hi2A-2eb0A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ASN A  36
VAL A 149
SER A 146
ASP A 147
GLU A  38
 None
None
None
MN  A 502 (-2.6A)
None
 1.46A 5jh7B-2eb0A:
undetectable		 5jh7B-2eb0A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ASN A  36
VAL A 149
SER A 146
THR A  12
GLU A  38
 None
 1.44A 5jh7B-2eb0A:
undetectable		 5jh7B-2eb0A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ASN A  36
VAL A 149
SER A 146
THR A  12
GLU A  38
 None
 1.46A 5jh7D-2eb0A:
undetectable		 5jh7D-2eb0A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 4 GLU A 197
PRO A 195
ILE A 198
LEU A 193
 None
 1.17A 5m45A-2eb0A:
undetectable		 5m45A-2eb0A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 4 GLU A 197
PRO A 195
ILE A 198
LEU A 193
 None
 1.18A 5m45D-2eb0A:
undetectable		 5m45D-2eb0A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 4 GLU A 197
PRO A 195
ILE A 198
LEU A 193
 None
 1.15A 5m45G-2eb0A:
undetectable		 5m45G-2eb0A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 4 GLU A 197
PRO A 195
ILE A 198
LEU A 193
 None
 1.21A 5m45J-2eb0A:
undetectable		 5m45J-2eb0A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 7 SER A  71
ARG A 303
ASP A 207
ASN A 306
 None
 0.98A 5n5dB-2eb0A:
undetectable		 5n5dB-2eb0A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A  87
HIS A  88
HIS A  89
HIS A   7
 None
MN  A 502 (-3.6A)
None
MN  A 501 (-3.5A)
 0.88A 5ncdA-2eb0A:
undetectable
5ncdD-2eb0A:
undetectable		 5ncdA-2eb0A:
23.29
5ncdD-2eb0A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 6 HIS A   7
ASP A  87
HIS A  88
HIS A  89
 MN  A 501 (-3.5A)
None
MN  A 502 (-3.6A)
None
 0.86A 5ncdB-2eb0A:
undetectable
5ncdC-2eb0A:
undetectable		 5ncdB-2eb0A:
23.29
5ncdC-2eb0A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ASP A  87
HIS A  88
HIS A  89
HIS A   7
 None
MN  A 502 (-3.6A)
None
MN  A 501 (-3.5A)
 0.92A 5nelA-2eb0A:
undetectable
5nelD-2eb0A:
undetectable		 5nelA-2eb0A:
23.29
5nelD-2eb0A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 11 GLY A 107
SER A 142
LEU A 141
GLU A 162
ALA A 164
 None
 0.95A 5o96G-2eb0A:
undetectable		 5o96G-2eb0A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 4 ASP A  11
SER A  14
ASP A  13
HIS A  88
 MN  A 501 (-2.5A)
MN  A 501 ( 3.7A)
MN  A 502 (-3.2A)
MN  A 502 (-3.6A)
 1.49A 5wyqB-2eb0A:
1.1		 5wyqB-2eb0A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A 125
ILE A 170
ALA A 137
LEU A 140
ALA A  16
 None
 1.30A 5zjiB-2eb0A:
undetectable		 5zjiB-2eb0A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 139
ASP A 147
ILE A  19
PRO A  51
SER A  14
 None
MN  A 502 (-2.6A)
None
None
MN  A 501 ( 3.7A)
 1.02A 6dlzB-2eb0A:
undetectable
6dlzC-2eb0A:
undetectable		 6dlzB-2eb0A:
12.96
6dlzC-2eb0A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A  19
PRO A  51
SER A  14
LEU A 139
ASP A 147
 None
None
MN  A 501 ( 3.7A)
None
MN  A 502 (-2.6A)
 1.02A 6dlzA-2eb0A:
undetectable
6dlzD-2eb0A:
undetectable		 6dlzA-2eb0A:
12.96
6dlzD-2eb0A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 139
ASP A 147
ILE A  19
PRO A  51
SER A  14
 None
MN  A 502 (-2.6A)
None
None
MN  A 501 ( 3.7A)
 1.05A 6dm0B-2eb0A:
undetectable
6dm0C-2eb0A:
undetectable		 6dm0B-2eb0A:
12.96
6dm0C-2eb0A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 139
ASP A 147
ILE A  19
PRO A  51
SER A  14
 None
MN  A 502 (-2.6A)
None
None
MN  A 501 ( 3.7A)
 1.02A 6dm1B-2eb0A:
undetectable
6dm1C-2eb0A:
undetectable		 6dm1B-2eb0A:
12.96
6dm1C-2eb0A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A  19
PRO A  51
SER A  14
LEU A 139
ASP A 147
 None
None
MN  A 501 ( 3.7A)
None
MN  A 502 (-2.6A)
 1.03A 6dm1A-2eb0A:
undetectable
6dm1D-2eb0A:
undetectable		 6dm1A-2eb0A:
12.96
6dm1D-2eb0A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 10 LEU A 139
ASP A 147
ILE A  19
PRO A  51
SER A  14
 None
MN  A 502 (-2.6A)
None
None
MN  A 501 ( 3.7A)
 1.04A 6dm2B-2eb0A:
undetectable
6dm2C-2eb0A:
undetectable		 6dm2B-2eb0A:
12.96
6dm2C-2eb0A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		5 / 10 ILE A  19
PRO A  51
SER A  14
LEU A 139
ASP A 147
 None
None
MN  A 501 ( 3.7A)
None
MN  A 502 (-2.6A)
 1.05A 6dm2A-2eb0A:
undetectable
6dm2D-2eb0A:
undetectable		 6dm2A-2eb0A:
12.96
6dm2D-2eb0A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 2eb0 MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE
(Methanocaldococc
us
jannaschii) 		4 / 6 ALA A 103
LEU A  82
SER A  68
THR A  95
 None
 0.98A 6f88B-2eb0A:
undetectable		 6f88B-2eb0A:
12.91