SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eb1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 2eb1 ENDORIBONUCLEASE
DICER
(Homo
sapiens) 		5 / 12 TYR A  99
PHE A  11
ILE A 153
VAL A 115
ILE A 111
 None
 1.18A 1c9hA-2eb1A:
undetectable		 1c9hA-2eb1A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 2eb1 ENDORIBONUCLEASE
DICER
(Homo
sapiens) 		5 / 11 ALA A  91
ILE A 153
LEU A  25
ILE A  15
TYR A 176
 None
 1.11A 1dg5A-2eb1A:
undetectable		 1dg5A-2eb1A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 2eb1 ENDORIBONUCLEASE
DICER
(Homo
sapiens) 		5 / 11 LEU A  54
GLY A 151
GLU A 155
ILE A  86
PRO A 182
 None
None
MG  A 502 (-2.6A)
None
None
 1.09A 1p91A-2eb1A:
undetectable		 1p91A-2eb1A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2eb1 ENDORIBONUCLEASE
DICER
(Homo
sapiens) 		4 / 7 ILE A  86
LEU A  90
PHE A  87
ARG A  78
 None
 1.06A 3ag2N-2eb1A:
undetectable
3ag2W-2eb1A:
undetectable		 3ag2N-2eb1A:
16.17
3ag2W-2eb1A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 2eb1 ENDORIBONUCLEASE
DICER
(Homo
sapiens) 		3 / 3 PHE A 100
SER A  33
SER A 104
 None
 0.93A 3ufgB-2eb1A:
undetectable		 3ufgB-2eb1A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2eb1 ENDORIBONUCLEASE
DICER
(Homo
sapiens) 		5 / 11 TYR A  99
PHE A  11
ILE A 153
ILE A 111
MET A 179
 None
 1.04A 4dz2A-2eb1A:
undetectable
4dz2B-2eb1A:
undetectable		 4dz2A-2eb1A:
17.74
4dz2B-2eb1A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2eb1 ENDORIBONUCLEASE
DICER
(Homo
sapiens) 		5 / 11 MET A 179
TYR A  99
PHE A  11
ILE A 153
ILE A 111
 None
 1.05A 4dz2A-2eb1A:
undetectable
4dz2B-2eb1A:
undetectable		 4dz2A-2eb1A:
17.74
4dz2B-2eb1A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2eb1 ENDORIBONUCLEASE
DICER
(Homo
sapiens) 		4 / 7 ASP A 152
ASN A  84
ASP A  51
GLU A  47
 MG  A 502 (-3.1A)
None
MG  A 505 (-2.8A)
MG  A 502 (-3.1A)
 1.12A 4fevB-2eb1A:
undetectable		 4fevB-2eb1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2eb1 ENDORIBONUCLEASE
DICER
(Homo
sapiens) 		4 / 6 ASP A 152
ASN A  84
ASP A  51
GLU A  47
 MG  A 502 (-3.1A)
None
MG  A 505 (-2.8A)
MG  A 502 (-3.1A)
 1.10A 4gkhJ-2eb1A:
undetectable		 4gkhJ-2eb1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2eb1 ENDORIBONUCLEASE
DICER
(Homo
sapiens) 		4 / 6 ILE A  86
LEU A  90
PHE A  87
ARG A  78
 None
 1.02A 5b1aN-2eb1A:
undetectable
5b1aW-2eb1A:
undetectable		 5b1aN-2eb1A:
16.17
5b1aW-2eb1A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 2eb1 ENDORIBONUCLEASE
DICER
(Homo
sapiens) 		5 / 12 TYR A  99
PHE A  11
ILE A 153
VAL A 115
ILE A 111
 None
 1.14A 5hkgA-2eb1A:
undetectable		 5hkgA-2eb1A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2eb1 ENDORIBONUCLEASE
DICER
(Homo
sapiens) 		5 / 7 LEU A  49
LEU A  25
ILE A  53
LEU A  54
ILE A  15
 None
 1.12A 5vkqA-2eb1A:
undetectable
5vkqB-2eb1A:
undetectable		 5vkqA-2eb1A:
7.55
5vkqB-2eb1A:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2eb1 ENDORIBONUCLEASE
DICER
(Homo
sapiens) 		5 / 8 LEU A  49
LEU A  25
ILE A  53
LEU A  54
ILE A  15
 None
 1.09A 5vkqB-2eb1A:
undetectable
5vkqC-2eb1A:
undetectable		 5vkqB-2eb1A:
7.55
5vkqC-2eb1A:
7.55