SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eb5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6J_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.49A 1p6jA-2eb5A:
undetectable
1p6jB-2eb5A:
undetectable		 1p6jA-2eb5A:
20.79
1p6jB-2eb5A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		5 / 12 LEU A  64
THR A  65
ALA A  68
ILE A 162
ILE A  36
 OXL  A2001 ( 4.7A)
OXL  A2001 ( 4.5A)
None
None
None
 0.99A 1qknA-2eb5A:
undetectable		 1qknA-2eb5A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 4 VAL A 207
LEU A 173
ILE A 234
LEU A  83
 None
 1.05A 2byoA-2eb5A:
undetectable		 2byoA-2eb5A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		5 / 8 ARG A 104
GLY A  63
THR A 161
ALA A 167
ALA A 166
 None
OXL  A2001 ( 3.3A)
None
None
None
 1.48A 2ej3C-2eb5A:
undetectable		 2ej3C-2eb5A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 8 LYS A  19
ASP A  86
GLU A  53
GLU A  18
 None
 1.30A 3dh0A-2eb5A:
undetectable		 3dh0A-2eb5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 5 LYS A  19
ASP A  86
GLU A  53
GLU A  18
 None
 1.24A 3dh0B-2eb5A:
0.0		 3dh0B-2eb5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_A_SAMA300_0
(PUTATIVE RRNA
METHYLASE)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		5 / 12 GLY A 214
ASN A 213
GLY A  81
GLN A  43
ASN A 220
 None
 0.94A 3eeyA-2eb5A:
undetectable		 3eeyA-2eb5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		5 / 12 GLY A 214
ASN A 213
GLY A  81
GLN A  43
ASN A 220
 None
 0.92A 3eeyC-2eb5A:
undetectable		 3eeyC-2eb5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_0
(PUTATIVE RRNA
METHYLASE)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		5 / 12 GLY A 214
ASN A 213
GLY A  81
GLN A  43
ASN A 220
 None
 0.93A 3eeyD-2eb5A:
undetectable		 3eeyD-2eb5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		5 / 12 GLY A 214
ASN A 213
GLY A  81
GLN A  43
ASN A 220
 None
 0.92A 3eeyE-2eb5A:
undetectable		 3eeyE-2eb5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_H_SAMH300_0
(PUTATIVE RRNA
METHYLASE)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		5 / 12 GLY A 214
ASN A 213
GLY A  81
GLN A  43
ASN A 220
 None
 0.93A 3eeyH-2eb5A:
undetectable		 3eeyH-2eb5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_I_SAMI300_0
(PUTATIVE RRNA
METHYLASE)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		5 / 12 GLY A 214
ASN A 213
GLY A  81
GLN A  43
ASN A 220
 None
 0.92A 3eeyI-2eb5A:
undetectable		 3eeyI-2eb5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_J_SAMJ300_0
(PUTATIVE RRNA
METHYLASE)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		5 / 12 GLY A 214
ASN A 213
GLY A  81
GLN A  43
ASN A 220
 None
 0.92A 3eeyJ-2eb5A:
undetectable		 3eeyJ-2eb5A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.49A 3jwvA-2eb5A:
undetectable
3jwvB-2eb5A:
undetectable		 3jwvA-2eb5A:
21.99
3jwvB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		3 / 3 TRP A  46
ALA A  52
VAL A  47
 None
 0.96A 3l8lA-2eb5A:
undetectable
3l8lB-2eb5A:
undetectable		 3l8lA-2eb5A:
6.70
3l8lB-2eb5A:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2R_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.49A 3n2rA-2eb5A:
undetectable
3n2rB-2eb5A:
undetectable		 3n2rA-2eb5A:
21.99
3n2rB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N5V_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 PHE A 252
GLU A 106
ARG A 194
VAL A 254
 None
MG  A1001 ( 3.1A)
None
None
 1.48A 3n5vA-2eb5A:
undetectable
3n5vB-2eb5A:
undetectable		 3n5vA-2eb5A:
21.99
3n5vB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		3 / 3 GLU A 139
LEU A 236
LEU A 208
 MG  A1001 ( 3.0A)
None
None
 0.72A 3ohtB-2eb5A:
undetectable		 3ohtB-2eb5A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		5 / 9 ILE A 135
LEU A 173
ILE A 235
MET A  87
GLY A 170
 None
 1.45A 3sj4X-2eb5A:
undetectable		 3sj4X-2eb5A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 6 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.50A 3ufqA-2eb5A:
undetectable
3ufqB-2eb5A:
undetectable		 3ufqA-2eb5A:
21.99
3ufqB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.50A 3ufsA-2eb5A:
undetectable
3ufsB-2eb5A:
undetectable		 3ufsA-2eb5A:
21.99
3ufsB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CDT_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.50A 4cdtA-2eb5A:
undetectable
4cdtB-2eb5A:
undetectable		 4cdtA-2eb5A:
21.99
4cdtB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D2Z_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.48A 4d2zA-2eb5A:
undetectable
4d2zB-2eb5A:
undetectable		 4d2zA-2eb5A:
21.99
4d2zB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D31_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.46A 4d31A-2eb5A:
undetectable
4d31B-2eb5A:
undetectable		 4d31A-2eb5A:
21.99
4d31B-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		3 / 3 ASP A 184
ARG A 186
ASP A 181
 None
 0.80A 4fp9A-2eb5A:
undetectable		 4fp9A-2eb5A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		3 / 3 ASP A 184
ARG A 186
ASP A 181
 None
 0.82A 4fp9C-2eb5A:
undetectable		 4fp9C-2eb5A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		3 / 3 ASP A 184
ARG A 186
ASP A 181
 None
 0.87A 4fp9F-2eb5A:
undetectable		 4fp9F-2eb5A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 6 GLY A 238
ASN A 168
GLU A 139
GLN A  70
 OXL  A2001 ( 3.6A)
None
MG  A1001 ( 3.0A)
None
 1.03A 4g0vB-2eb5A:
undetectable		 4g0vB-2eb5A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCM_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.48A 4kcmA-2eb5A:
undetectable
4kcmB-2eb5A:
undetectable		 4kcmA-2eb5A:
21.99
4kcmB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ASN A 168
GLU A 139
GLU A 106
ARG A 104
 None
MG  A1001 ( 3.0A)
MG  A1001 ( 3.1A)
None
 0.86A 4mi4B-2eb5A:
undetectable
4mi4C-2eb5A:
undetectable		 4mi4B-2eb5A:
21.13
4mi4C-2eb5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 8 ASN A 168
GLU A 139
GLU A 106
ARG A 104
 None
MG  A1001 ( 3.0A)
MG  A1001 ( 3.1A)
None
 0.89A 4mj8B-2eb5A:
undetectable
4mj8C-2eb5A:
undetectable		 4mj8B-2eb5A:
20.73
4mj8C-2eb5A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH0_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.48A 4uh0A-2eb5A:
undetectable
4uh0B-2eb5A:
undetectable		 4uh0A-2eb5A:
21.99
4uh0B-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.50A 4uh4A-2eb5A:
undetectable
4uh4B-2eb5A:
undetectable		 4uh4A-2eb5A:
21.99
4uh4B-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPM_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.48A 4upmA-2eb5A:
undetectable
4upmB-2eb5A:
undetectable		 4upmA-2eb5A:
21.99
4upmB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UPN_A_H4BA760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.48A 4upnA-2eb5A:
undetectable
4upnB-2eb5A:
undetectable		 4upnA-2eb5A:
21.99
4upnB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3V_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 6 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.50A 4v3vA-2eb5A:
undetectable
4v3vB-2eb5A:
undetectable		 4v3vA-2eb5A:
21.99
4v3vB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_B_DM2B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		5 / 11 VAL A 112
PHE A  88
GLY A  81
ASN A 165
ILE A  62
 None
 1.44A 4zvmA-2eb5A:
undetectable
4zvmB-2eb5A:
undetectable		 4zvmA-2eb5A:
21.71
4zvmB-2eb5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.50A 5adaA-2eb5A:
undetectable
5adaB-2eb5A:
undetectable		 5adaA-2eb5A:
21.99
5adaB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADC_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 6 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.48A 5adcA-2eb5A:
undetectable
5adcB-2eb5A:
undetectable		 5adcA-2eb5A:
21.99
5adcB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AGO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.47A 5agoA-2eb5A:
undetectable
5agoB-2eb5A:
undetectable		 5agoA-2eb5A:
21.99
5agoB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 PHE A 252
GLU A 106
ARG A 194
VAL A 254
 None
MG  A1001 ( 3.1A)
None
None
 1.50A 5unrA-2eb5A:
undetectable
5unrB-2eb5A:
undetectable		 5unrA-2eb5A:
21.99
5unrB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.48A 5unuA-2eb5A:
undetectable
5unuB-2eb5A:
undetectable		 5unuA-2eb5A:
21.99
5unuB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.48A 5unwA-2eb5A:
undetectable
5unwB-2eb5A:
undetectable		 5unwA-2eb5A:
21.99
5unwB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.48A 5unyA-2eb5A:
undetectable
5unyB-2eb5A:
undetectable		 5unyA-2eb5A:
21.99
5unyB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 PHE A 252
GLU A 106
ARG A 194
VAL A 254
 None
MG  A1001 ( 3.1A)
None
None
 1.49A 5unyA-2eb5A:
undetectable
5unyB-2eb5A:
undetectable		 5unyA-2eb5A:
21.99
5unyB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 PHE A 252
GLU A 106
ARG A 194
VAL A 254
 None
MG  A1001 ( 3.1A)
None
None
 1.50A 5unzA-2eb5A:
undetectable
5unzB-2eb5A:
undetectable		 5unzA-2eb5A:
21.99
5unzB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.49A 5uo3A-2eb5A:
undetectable
5uo3B-2eb5A:
undetectable		 5uo3A-2eb5A:
20.33
5uo3B-2eb5A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO4_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.47A 5uo4A-2eb5A:
undetectable
5uo4B-2eb5A:
undetectable		 5uo4A-2eb5A:
20.33
5uo4B-2eb5A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.49A 5uo5A-2eb5A:
undetectable
5uo5B-2eb5A:
undetectable		 5uo5A-2eb5A:
20.33
5uo5B-2eb5A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.48A 5vuiA-2eb5A:
undetectable
5vuiB-2eb5A:
undetectable		 5vuiA-2eb5A:
21.99
5vuiB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUJ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 PHE A 252
GLU A 106
ARG A 194
VAL A 254
 None
MG  A1001 ( 3.1A)
None
None
 1.48A 5vujA-2eb5A:
undetectable
5vujB-2eb5A:
undetectable		 5vujA-2eb5A:
21.99
5vujB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUK_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.47A 5vukA-2eb5A:
undetectable
5vukB-2eb5A:
undetectable		 5vukA-2eb5A:
21.99
5vukB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 PHE A 252
GLU A 106
ARG A 194
VAL A 254
 None
MG  A1001 ( 3.1A)
None
None
 1.50A 5vuoA-2eb5A:
undetectable
5vuoB-2eb5A:
undetectable		 5vuoA-2eb5A:
21.99
5vuoB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUS_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.43A 5vusA-2eb5A:
undetectable
5vusB-2eb5A:
undetectable		 5vusA-2eb5A:
21.99
5vusB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.48A 5vuuA-2eb5A:
undetectable
5vuuB-2eb5A:
undetectable		 5vuuA-2eb5A:
21.99
5vuuB-2eb5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.43A 5vuyA-2eb5A:
undetectable
5vuyB-2eb5A:
undetectable		 5vuyA-2eb5A:
20.33
5vuyB-2eb5A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 6 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.46A 5vv1A-2eb5A:
undetectable
5vv1B-2eb5A:
undetectable		 5vv1A-2eb5A:
20.33
5vv1B-2eb5A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.48A 5vv5A-2eb5A:
undetectable
5vv5B-2eb5A:
undetectable		 5vv5A-2eb5A:
20.33
5vv5B-2eb5A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		5 / 12 GLY A 170
SER A 263
ASP A 255
ALA A 190
PRO A 136
 None
 1.33A 5zvgA-2eb5A:
undetectable		 5zvgA-2eb5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		5 / 12 GLY A 170
SER A 263
ASP A 255
ALA A 190
PRO A 136
 None
 1.32A 5zvgB-2eb5A:
undetectable		 5zvgB-2eb5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.47A 6autA-2eb5A:
undetectable
6autB-2eb5A:
undetectable		 6autA-2eb5A:
13.55
6autB-2eb5A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUW_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.48A 6auwA-2eb5A:
undetectable
6auwB-2eb5A:
undetectable		 6auwA-2eb5A:
13.55
6auwB-2eb5A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.48A 6auxA-2eb5A:
undetectable
6auxB-2eb5A:
undetectable		 6auxA-2eb5A:
13.55
6auxB-2eb5A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 PHE A 252
GLU A 106
ARG A 194
VAL A 254
 None
MG  A1001 ( 3.1A)
None
None
 1.48A 6auxA-2eb5A:
undetectable
6auxB-2eb5A:
undetectable		 6auxA-2eb5A:
13.55
6auxB-2eb5A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.48A 6av1A-2eb5A:
undetectable
6av1B-2eb5A:
undetectable		 6av1A-2eb5A:
14.40
6av1B-2eb5A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 7 ARG A 194
VAL A 254
PHE A 252
GLU A 106
 None
None
None
MG  A1001 ( 3.1A)
 1.49A 6av5A-2eb5A:
undetectable
6av5B-2eb5A:
undetectable		 6av5A-2eb5A:
14.40
6av5B-2eb5A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 5 HIS A  60
GLU A 139
LEU A 208
VAL A 207
 None
MG  A1001 ( 3.0A)
None
None
 1.20A 6bc9A-2eb5A:
undetectable		 6bc9A-2eb5A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE
(Escherichia
coli) 		4 / 4 HIS A 210
VAL A 134
LEU A 185
ALA A 212
 None
 1.42A 6d8pB-2eb5A:
undetectable		 6d8pB-2eb5A:
15.74