SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eba'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_2
(ADENOSINE DEAMINASE)		 2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 HIS A  46
LEU A  26
SER A 210
LEU A 207
 None
None
None
FAD  A1001 (-4.2A)
 1.12A 1a4lB-2ebaA:
undetectable		 1a4lB-2ebaA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 THR A 360
SER A  91
THR A 165
THR A 212
 FAD  A1001 (-3.3A)
None
FAD  A1001 (-4.0A)
FAD  A1001 ( 4.2A)
 0.98A 1gtnF-2ebaA:
undetectable
1gtnG-2ebaA:
undetectable		 1gtnF-2ebaA:
13.98
1gtnG-2ebaA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 4 LYS A 178
ALA A 177
MET A 144
 None
 1.05A 1hk3A-2ebaA:
undetectable		 1hk3A-2ebaA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A 247
GLY A  76
ALA A 305
LEU A 304
VAL A 361
 None
 1.13A 1i9gA-2ebaA:
undetectable		 1i9gA-2ebaA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ILE A  78
GLY A 247
SER A  72
ALA A  74
VAL A 361
 None
 1.23A 1i9gA-2ebaA:
undetectable		 1i9gA-2ebaA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 LEU A 358
ALA A 265
ALA A 263
LEU A 256
ARG A 353
 None
 1.25A 1iiuA-2ebaA:
undetectable		 1iiuA-2ebaA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A 358
ALA A 265
ALA A 263
LEU A 256
ARG A 353
 None
 1.31A 1kt5A-2ebaA:
undetectable		 1kt5A-2ebaA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ASP A 139
LYS A 145
ARG A 147
 None
 1.15A 1ra8A-2ebaA:
undetectable		 1ra8A-2ebaA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 VAL A 222
GLU A 224
LEU A 226
PHE A 187
 None
 0.84A 1s8fB-2ebaA:
undetectable		 1s8fB-2ebaA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 GLY A  58
LEU A  57
PHE A  51
LEU A  82
ILE A  78
 None
 1.08A 2f8dA-2ebaA:
undetectable		 2f8dA-2ebaA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 GLY A  58
LEU A  57
PHE A  51
LEU A  82
ILE A  78
 None
 1.09A 2f8dB-2ebaA:
undetectable		 2f8dB-2ebaA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 GLU A 218
GLY A 159
THR A 160
GLU A 133
 None
 1.03A 3e9xA-2ebaA:
undetectable		 3e9xA-2ebaA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 LEU A 298
GLU A 289
GLY A 297
LEU A 256
ALA A 288
 None
 1.05A 3ou6C-2ebaA:
undetectable		 3ou6C-2ebaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 THR A 132
GLY A 130
ARG A 147
ILE A 175
 FAD  A1001 (-3.2A)
FAD  A1001 ( 4.6A)
None
None
 1.07A 4acbC-2ebaA:
undetectable		 4acbC-2ebaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 SER A  91
GLY A  88
THR A 212
ASP A  86
 None
None
FAD  A1001 ( 4.2A)
None
 1.10A 4eohA-2ebaA:
undetectable		 4eohA-2ebaA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 ALA A 329
ALA A 332
ALA A 333
ALA A 336
 None
 0.13A 4oadA-2ebaA:
undetectable		 4oadA-2ebaA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 ALA A 329
ALA A 332
ALA A 333
ALA A 336
 None
 0.10A 4oaeA-2ebaA:
undetectable		 4oaeA-2ebaA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 ALA A 148
TRP A 155
VAL A 156
 None
 0.42A 4w9nC-2ebaA:
undetectable		 4w9nC-2ebaA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XZK_A_AG2A700_1
(PUTATIVE
NAD(+)--ARGININE
ADP-RIBOSYLTRANSFERA
SE VIS)		 2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 SER A 225
SER A 109
PHE A 116
GLU A 111
 None
 1.36A 4xzkA-2ebaA:
undetectable		 4xzkA-2ebaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 GLY A 247
GLY A  76
LEU A 300
ALA A 321
 None
 0.73A 5o96C-2ebaA:
undetectable		 5o96C-2ebaA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2eba PUTATIVE
GLUTARYL-COA
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 VAL A 259
ALA A 332
TYR A  80
ALA A 329
LEU A 358
 None
 1.10A 6dk1B-2ebaA:
0.0		 6dk1B-2ebaA:
21.00