SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ebd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		5 / 12 ILE A 242
ASN A 266
LEU A 204
GLY A 201
PHE A 205
 None
 1.26A 1hvyA-2ebdA:
undetectable		 1hvyA-2ebdA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		5 / 12 ILE A 242
ASN A 266
LEU A 204
GLY A 201
PHE A 205
 None
 1.30A 1hvyB-2ebdA:
undetectable		 1hvyB-2ebdA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		5 / 11 ILE A 242
ASN A 266
LEU A 204
GLY A 201
PHE A 205
 None
 1.35A 1hvyC-2ebdA:
undetectable		 1hvyC-2ebdA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		4 / 7 VAL A  10
TYR A  11
GLY A 161
TYR A 264
 None
 1.01A 1lweA-2ebdA:
undetectable		 1lweA-2ebdA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		4 / 5 GLU A 187
LEU A 300
LEU A 185
LEU A 189
 None
 1.05A 1np1A-2ebdA:
undetectable		 1np1A-2ebdA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		3 / 3 ILE A 136
ILE A  75
THR A  79
 None
 0.62A 1rg7A-2ebdA:
undetectable		 1rg7A-2ebdA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		5 / 12 PRO A  13
ILE A 261
GLY A 265
GLY A 157
ILE A 274
 None
 0.91A 1sg9B-2ebdA:
undetectable		 1sg9B-2ebdA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		4 / 6 ILE A 107
ALA A 109
THR A 301
ALA A 295
 None
 0.99A 1w0gA-2ebdA:
undetectable		 1w0gA-2ebdA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		5 / 12 ILE A 174
ALA A 176
LEU A 292
ALA A 223
VAL A 165
 None
 1.05A 1xiuB-2ebdA:
undetectable		 1xiuB-2ebdA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		5 / 11 ILE A 174
ALA A 176
LEU A 292
ALA A 223
ILE A   5
 None
 1.07A 2aclE-2ebdA:
undetectable		 2aclE-2ebdA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		5 / 12 ILE A  76
ILE A 107
ALA A 109
THR A 301
ALA A 295
 None
 1.09A 2j0dA-2ebdA:
undetectable		 2j0dA-2ebdA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		4 / 6 LEU A 276
VAL A 163
ILE A   5
ILE A 291
 None
 0.91A 2piwA-2ebdA:
undetectable		 2piwA-2ebdA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		5 / 11 LEU A  12
ALA A 275
PHE A 258
ALA A 279
GLN A 262
 None
 1.47A 3bszF-2ebdA:
undetectable		 3bszF-2ebdA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E00_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		5 / 12 ILE A 174
ALA A 176
ALA A 223
VAL A 165
ILE A   5
 None
 0.97A 3e00A-2ebdA:
undetectable		 3e00A-2ebdA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		3 / 3 ARG A 198
THR A 301
THR A  81
 None
 0.69A 3k2hB-2ebdA:
undetectable		 3k2hB-2ebdA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		5 / 12 LEU A  97
ALA A 117
VAL A 163
GLY A   7
ALA A  61
 None
 1.08A 3ln1D-2ebdA:
0.3		 3ln1D-2ebdA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		3 / 3 ARG A 241
ILE A  33
TRP A  32
 None
 1.07A 3nw2B-2ebdA:
undetectable		 3nw2B-2ebdA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		5 / 12 GLY A 303
ILE A 115
LEU A 292
GLU A 218
VAL A 219
 None
 1.12A 3o7wA-2ebdA:
undetectable		 3o7wA-2ebdA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		5 / 12 GLY A   7
ILE A 280
LEU A  67
ASN A  66
LEU A 134
 None
 1.18A 3q87B-2ebdA:
undetectable		 3q87B-2ebdA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		4 / 7 ILE A  50
LEU A  77
ALA A  57
ALA A  58
 None
 0.73A 3r9tB-2ebdA:
undetectable		 3r9tB-2ebdA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		4 / 7 LEU A 141
ALA A 270
ILE A  76
THR A  81
 None
 0.97A 4eyrA-2ebdA:
undetectable		 4eyrA-2ebdA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		5 / 12 ILE A 174
ALA A 176
LEU A 292
ILE A 291
ALA A 223
 None
 1.08A 4k6iA-2ebdA:
undetectable		 4k6iA-2ebdA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		4 / 8 MET A 293
ALA A 304
MET A 179
VAL A 133
 None
 1.03A 4ltwA-2ebdA:
undetectable		 4ltwA-2ebdA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		4 / 5 ILE A 274
PRO A 273
TYR A 309
VAL A 285
 None
 1.12A 4s0vA-2ebdA:
undetectable		 4s0vA-2ebdA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_B_LOCB502_2
(TUBULIN BETA CHAIN)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		5 / 12 LEU A  97
ALA A  58
ALA A 104
VAL A 102
ALA A  99
 None
 1.19A 4x1iB-2ebdA:
undetectable		 4x1iB-2ebdA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		4 / 5 LEU A 220
GLU A 218
MET A 212
LEU A 246
 None
 1.31A 4xi3B-2ebdA:
undetectable		 4xi3B-2ebdA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		5 / 12 LEU A  97
ALA A 117
VAL A 163
GLY A   7
ALA A  61
 None
 1.06A 5jw1A-2ebdA:
undetectable		 5jw1A-2ebdA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		5 / 12 LEU A  97
ALA A 117
VAL A 163
GLY A   7
ALA A  61
 None
 1.07A 5jw1B-2ebdA:
undetectable		 5jw1B-2ebdA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		5 / 9 ASP A 146
ILE A 197
GLY A 195
THR A  81
PRO A  82
 None
 1.21A 5kr2C-2ebdA:
undetectable		 5kr2C-2ebdA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		5 / 12 ILE A 234
HIS A 236
ALA A 275
ILE A 280
ALA A 279
 None
 1.06A 5n0tB-2ebdA:
undetectable		 5n0tB-2ebdA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		5 / 9 VAL A 165
LEU A 118
ALA A 117
PHE A 114
ILE A   5
 None
 1.20A 5om2A-2ebdA:
undetectable
5om2B-2ebdA:
undetectable		 5om2A-2ebdA:
14.62
5om2B-2ebdA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		5 / 12 ALA A 247
VAL A 233
LEU A 292
VAL A 259
VAL A 257
 None
 0.95A 6dh0B-2ebdA:
undetectable		 6dh0B-2ebdA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3
(Aquifex
aeolicus) 		5 / 12 VAL A 133
ILE A 115
LEU A  74
VAL A 163
VAL A 165
 None
 0.97A 6dh0B-2ebdA:
undetectable		 6dh0B-2ebdA:
15.57