SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ebj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 2ebj PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermus
thermophilus) 		4 / 4 LEU A  39
PRO A  40
LEU A  46
ARG A 149
 None
 1.39A 1hrkB-2ebjA:
5.0		 1hrkB-2ebjA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 2ebj PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 159
LEU A  73
GLN A 181
LEU A  21
CYH A 139
 None
 1.27A 2aa6A-2ebjA:
undetectable		 2aa6A-2ebjA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 2ebj PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermus
thermophilus) 		4 / 4 LEU A  39
PRO A  40
LEU A  46
ARG A 149
 None
 1.39A 2hrcB-2ebjA:
4.8		 2hrcB-2ebjA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ebj PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermus
thermophilus) 		4 / 4 LEU A  39
PRO A  40
LEU A  46
ARG A 149
 None
 1.44A 2pnjB-2ebjA:
4.3		 2pnjB-2ebjA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 2ebj PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermus
thermophilus) 		4 / 4 LEU A  39
PRO A  40
LEU A  46
ARG A 149
 None
 1.36A 2qd2A-2ebjA:
4.9		 2qd2A-2ebjA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 2ebj PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermus
thermophilus) 		4 / 8 LEU A 178
PRO A   9
VAL A  38
GLY A   6
 None
 0.84A 2qd5A-2ebjA:
4.8		 2qd5A-2ebjA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 2ebj PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermus
thermophilus) 		5 / 12 LEU A 147
LEU A  62
ALA A 110
GLY A  65
VAL A 117
 None
 1.04A 3c6gA-2ebjA:
undetectable		 3c6gA-2ebjA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 2ebj PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermus
thermophilus) 		5 / 12 GLY A 157
GLY A  65
VAL A 185
ALA A 134
PHE A   7
 None
 1.30A 3qowA-2ebjA:
undetectable		 3qowA-2ebjA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ebj PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermus
thermophilus) 		5 / 8 ALA A 188
LEU A  62
LEU A  64
LEU A  21
LEU A  25
 None
 1.13A 4z90A-2ebjA:
undetectable
4z90B-2ebjA:
undetectable
4z90C-2ebjA:
undetectable
4z90D-2ebjA:
undetectable
4z90E-2ebjA:
undetectable		 4z90A-2ebjA:
21.90
4z90B-2ebjA:
21.90
4z90C-2ebjA:
21.90
4z90D-2ebjA:
21.90
4z90E-2ebjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ebj PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermus
thermophilus) 		5 / 8 LEU A  21
LEU A  25
ALA A 188
LEU A  62
LEU A  64
 None
 1.10A 4z90A-2ebjA:
undetectable
4z90B-2ebjA:
undetectable
4z90C-2ebjA:
undetectable
4z90D-2ebjA:
undetectable
4z90E-2ebjA:
undetectable		 4z90A-2ebjA:
21.90
4z90B-2ebjA:
21.90
4z90C-2ebjA:
21.90
4z90D-2ebjA:
21.90
4z90E-2ebjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ebj PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermus
thermophilus) 		5 / 8 LEU A  62
LEU A  64
LEU A  21
LEU A  25
ALA A 188
 None
 1.06A 4z90A-2ebjA:
undetectable
4z90B-2ebjA:
undetectable
4z90C-2ebjA:
undetectable
4z90D-2ebjA:
undetectable
4z90E-2ebjA:
undetectable		 4z90A-2ebjA:
21.90
4z90B-2ebjA:
21.90
4z90C-2ebjA:
21.90
4z90D-2ebjA:
21.90
4z90E-2ebjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ebj PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermus
thermophilus) 		6 / 9 LEU A  21
ALA A 182
LEU A  25
ALA A 188
LEU A  62
LEU A  64
 None
 1.19A 4z91F-2ebjA:
undetectable
4z91G-2ebjA:
undetectable
4z91H-2ebjA:
undetectable
4z91I-2ebjA:
undetectable
4z91J-2ebjA:
undetectable		 4z91F-2ebjA:
21.90
4z91G-2ebjA:
21.90
4z91H-2ebjA:
21.90
4z91I-2ebjA:
21.90
4z91J-2ebjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ebj PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermus
thermophilus) 		6 / 9 LEU A  25
ALA A 188
LEU A  62
LEU A  64
LEU A  21
ALA A 182
 None
 1.18A 4z91F-2ebjA:
undetectable
4z91G-2ebjA:
undetectable
4z91H-2ebjA:
undetectable
4z91I-2ebjA:
undetectable
4z91J-2ebjA:
undetectable		 4z91F-2ebjA:
21.90
4z91G-2ebjA:
21.90
4z91H-2ebjA:
21.90
4z91I-2ebjA:
21.90
4z91J-2ebjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ebj PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermus
thermophilus) 		6 / 9 LEU A  25
LEU A 189
ALA A 188
LEU A  62
LEU A  64
LEU A  21
 None
 1.21A 4z91F-2ebjA:
undetectable
4z91G-2ebjA:
undetectable
4z91H-2ebjA:
undetectable
4z91I-2ebjA:
undetectable
4z91J-2ebjA:
undetectable		 4z91F-2ebjA:
21.90
4z91G-2ebjA:
21.90
4z91H-2ebjA:
21.90
4z91I-2ebjA:
21.90
4z91J-2ebjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ebj PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermus
thermophilus) 		7 / 9 LEU A  62
LEU A  64
LEU A  21
ALA A 182
LEU A  25
LEU A 189
ALA A 188
 None
 1.31A 4z91F-2ebjA:
undetectable
4z91G-2ebjA:
undetectable
4z91H-2ebjA:
undetectable
4z91I-2ebjA:
undetectable
4z91J-2ebjA:
undetectable		 4z91F-2ebjA:
21.90
4z91G-2ebjA:
21.90
4z91H-2ebjA:
21.90
4z91I-2ebjA:
21.90
4z91J-2ebjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ebj PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermus
thermophilus) 		6 / 9 LEU A  64
LEU A  21
ALA A 182
LEU A  25
LEU A 189
LEU A  62
 None
 1.21A 4z91F-2ebjA:
undetectable
4z91G-2ebjA:
undetectable
4z91H-2ebjA:
undetectable
4z91I-2ebjA:
undetectable
4z91J-2ebjA:
undetectable		 4z91F-2ebjA:
21.90
4z91G-2ebjA:
21.90
4z91H-2ebjA:
21.90
4z91I-2ebjA:
21.90
4z91J-2ebjA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2ebj PYRROLIDONE CARBOXYL
PEPTIDASE
(Thermus
thermophilus) 		6 / 9 LEU A 189
ALA A 188
LEU A  62
LEU A  64
LEU A  21
LEU A  25
 None
 1.15A 4z91F-2ebjA:
undetectable
4z91G-2ebjA:
undetectable
4z91H-2ebjA:
undetectable
4z91I-2ebjA:
undetectable
4z91J-2ebjA:
undetectable		 4z91F-2ebjA:
21.90
4z91G-2ebjA:
21.90
4z91H-2ebjA:
21.90
4z91I-2ebjA:
21.90
4z91J-2ebjA:
21.90