SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ebw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2ebw DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		4 / 7 TRP A 113
GLU A 116
SER A 117
VAL A 115
 None
 1.23A 3dqtA-2ebwA:
undetectable
3dqtB-2ebwA:
undetectable		 3dqtA-2ebwA:
13.22
3dqtB-2ebwA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 2ebw DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		4 / 4 ILE A  54
PHE A  49
ILE A 114
THR A  88
 None
 1.16A 3ia4A-2ebwA:
undetectable		 3ia4A-2ebwA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N61_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE)		 2ebw DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		4 / 7 TRP A 113
GLU A 116
SER A 117
VAL A 115
 None
 1.17A 3n61A-2ebwA:
undetectable
3n61B-2ebwA:
undetectable		 3n61A-2ebwA:
13.28
3n61B-2ebwA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2ebw DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		4 / 8 TRP A 113
GLU A 116
SER A 117
VAL A 115
 None
 1.13A 3nlrA-2ebwA:
undetectable
3nlrB-2ebwA:
undetectable		 3nlrA-2ebwA:
13.28
3nlrB-2ebwA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 2ebw DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		4 / 7 TRP A 113
GLU A 116
SER A 117
VAL A 115
 None
 1.23A 5adlA-2ebwA:
undetectable
5adlB-2ebwA:
undetectable		 5adlA-2ebwA:
13.61
5adlB-2ebwA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2ebw DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		4 / 7 TRP A 113
GLU A 116
SER A 117
VAL A 115
 None
 1.25A 5fj3A-2ebwA:
undetectable
5fj3B-2ebwA:
undetectable		 5fj3A-2ebwA:
13.61
5fj3B-2ebwA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV7_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2ebw DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		4 / 7 TRP A 113
GLU A 116
SER A 117
VAL A 115
 None
 1.23A 5vv7A-2ebwA:
undetectable
5vv7B-2ebwA:
undetectable		 5vv7A-2ebwA:
13.61
5vv7B-2ebwA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VVN_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2ebw DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		4 / 7 TRP A 113
GLU A 116
SER A 117
VAL A 115
 None
 1.24A 5vvnA-2ebwA:
undetectable
5vvnB-2ebwA:
undetectable		 5vvnA-2ebwA:
13.61
5vvnB-2ebwA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB501_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2ebw DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		4 / 7 SER A 117
VAL A 115
TRP A 113
GLU A 116
 None
 1.26A 6av6A-2ebwA:
undetectable
6av6B-2ebwA:
undetectable		 6av6A-2ebwA:
15.31
6av6B-2ebwA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_D_H4BD502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2ebw DNA REPAIR PROTEIN
REV1
(Homo
sapiens) 		4 / 7 TRP A 113
GLU A 116
SER A 117
VAL A 115
 None
 1.22A 6av6C-2ebwA:
undetectable
6av6D-2ebwA:
undetectable		 6av6C-2ebwA:
15.31
6av6D-2ebwA:
15.31