SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ec4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HVY_A_D16A414_1 (THYMIDYLATE SYNTHASE)	2ec4	FAS-ASSOCIATED FACTOR 1 (Homo sapiens)	5 / 12	PHE A 35 TRP A 96 ASN A 103 ASP A 15 GLY A 14	None	1.10A	1hvyA-2ec4A: undetectable	1hvyA-2ec4A: 19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HVY_C_D16C416_1 (THYMIDYLATE SYNTHASE)	2ec4	FAS-ASSOCIATED FACTOR 1 (Homo sapiens)	5 / 11	PHE A 35 TRP A 96 ASN A 103 ASP A 15 GLY A 14	None	0.99A	1hvyC-2ec4A: undetectable	1hvyC-2ec4A: 19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PRG_A_BRLA1_2 (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA)	2ec4	FAS-ASSOCIATED FACTOR 1 (Homo sapiens)	3 / 3	ILE A 136 ILE A 150 LEU A 40	None	0.53A	2prgA-2ec4A: undetectable	2prgA-2ec4A: 22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KM9_B_ADNB201_1 (HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 2, MITOCHONDRIAL)	2ec4	FAS-ASSOCIATED FACTOR 1 (Homo sapiens)	5 / 12	ILE A 60 ILE A 137 VAL A 119 ALA A 120 HIS A 114	None	1.21A	5km9B-2ec4A: undetectable	5km9B-2ec4A: 20.11

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1HVY_A_D16A414_1","THYMIDYLATE SYNTHASE","2ec4","FAS-ASSOCIATED FACTOR 1","Homo sapiens",5,"PHE A  35;TRP A  96;ASN A 103;ASP A  15;GLY A  14","None","1.10A","1hvyA-2ec4A:undetectable","1hvyA-2ec4A:19.27"],["1HVY_C_D16C416_1","THYMIDYLATE SYNTHASE","2ec4","FAS-ASSOCIATED FACTOR 1","Homo sapiens",5,"PHE A  35;TRP A  96;ASN A 103;ASP A  15;GLY A  14","None","0.99A","1hvyC-2ec4A:undetectable","1hvyC-2ec4A:19.27"],["2PRG_A_BRLA1_2","PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA","2ec4","FAS-ASSOCIATED FACTOR 1","Homo sapiens",3,"ILE A 136;ILE A 150;LEU A  40","None","0.53A","2prgA-2ec4A:undetectable","2prgA-2ec4A:22.30"],["5KM9_B_ADNB201_1","HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 2, MITOCHONDRIAL","2ec4","FAS-ASSOCIATED FACTOR 1","Homo sapiens",5,"ILE A  60;ILE A 137;VAL A 119;ALA A 120;HIS A 114","None","1.21A","5km9B-2ec4A:undetectable","5km9B-2ec4A:20.11"]]