SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ec5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 0.98A 1dhiA-2ec5A:
2.3		 1dhiA-2ec5A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 11 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 0.99A 1dhiB-2ec5A:
2.2		 1dhiB-2ec5A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 0.98A 1dhjA-2ec5A:
2.3		 1dhjA-2ec5A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 0.98A 1dhjB-2ec5A:
2.3		 1dhjB-2ec5A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 1.01A 1draA-2ec5A:
2.3		 1draA-2ec5A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 0.99A 1draB-2ec5A:
2.3		 1draB-2ec5A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_B_ESTB1600_1
(ESTROGEN RECEPTOR)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 LEU A 681
LEU A 694
LEU A 695
MET A 638
GLY A 687
 None
 1.17A 1g50B-2ec5A:
undetectable		 1g50B-2ec5A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_C_ESTC2600_1
(ESTROGEN RECEPTOR)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 11 LEU A 681
LEU A 694
LEU A 695
MET A 638
GLY A 687
 None
 1.17A 1g50C-2ec5A:
undetectable		 1g50C-2ec5A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		3 / 3 ARG A1086
GLY A 885
ASP A 881
 None
 0.54A 1kf6A-2ec5A:
4.0
1kf6B-2ec5A:
undetectable		 1kf6A-2ec5A:
20.05
1kf6B-2ec5A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		4 / 7 ASP A 739
GLY A 803
ILE A 802
ILE A 734
 None
 0.73A 1n49A-2ec5A:
undetectable		 1n49A-2ec5A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		4 / 6 ASP A 739
GLY A 803
ILE A 802
ILE A 734
 None
 0.71A 1n49D-2ec5A:
undetectable		 1n49D-2ec5A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 0.88A 1ra2A-2ec5A:
undetectable		 1ra2A-2ec5A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 0.94A 1ra3A-2ec5A:
undetectable		 1ra3A-2ec5A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 0.86A 1ra8A-2ec5A:
2.1		 1ra8A-2ec5A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 0.98A 1rb2A-2ec5A:
undetectable		 1rb2A-2ec5A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 0.99A 1rd7A-2ec5A:
2.2		 1rd7A-2ec5A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 1.01A 1rd7B-2ec5A:
2.2		 1rd7B-2ec5A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 0.88A 1rx2A-2ec5A:
undetectable		 1rx2A-2ec5A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_1
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 941
PHE A 914
GLN A 915
PRO A1066
LEU A1046
 None
 1.37A 1u70A-2ec5A:
2.5		 1u70A-2ec5A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		4 / 6 ILE A 755
VAL A 838
VAL A 742
ILE A 738
 None
 0.83A 1uwhB-2ec5A:
2.6		 1uwhB-2ec5A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		3 / 3 LEU A 681
HIS A 635
LYS A 686
 None
 1.01A 1y7iA-2ec5A:
undetectable		 1y7iA-2ec5A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 11 TYR A1017
GLU A 845
VAL A 722
ILE A 723
PHE A 716
 None
 1.18A 2dg9A-2ec5A:
undetectable		 2dg9A-2ec5A:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 1.02A 2drcB-2ec5A:
2.3		 2drcB-2ec5A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		3 / 3 PHE A 844
PHE A 832
PHE A 831
 None
 0.80A 2od9A-2ec5A:
undetectable		 2od9A-2ec5A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		3 / 3 PHE A 844
PHE A 832
PHE A 831
 None
 0.80A 2qqgA-2ec5A:
undetectable		 2qqgA-2ec5A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		4 / 6 TYR A 811
PRO A 945
ILE A 999
LEU A1045
 None
 1.35A 2wekB-2ec5A:
undetectable		 2wekB-2ec5A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		4 / 8 LEU A 637
ILE A 614
LEU A 618
LEU A 664
 None
 0.77A 2xfhA-2ec5A:
undetectable		 2xfhA-2ec5A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		3 / 3 PRO A 593
LEU A 596
ARG A 653
 None
 0.75A 3aqiA-2ec5A:
undetectable		 3aqiA-2ec5A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		4 / 7 SER A 774
VAL A 838
ILE A 749
ASP A 753
 None
 1.08A 3bu1A-2ec5A:
undetectable		 3bu1A-2ec5A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 1.00A 3drcB-2ec5A:
2.3		 3drcB-2ec5A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		3 / 3 MET A1142
MET A1179
PHE A1217
 None
 1.36A 3gn8A-2ec5A:
undetectable		 3gn8A-2ec5A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B2000_1
(P38A)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 10 ARG A 861
ILE A1023
TYR A1062
ILE A1027
ASN A 867
 None
 1.48A 3ohtA-2ec5A:
undetectable
3ohtB-2ec5A:
3.2		 3ohtA-2ec5A:
20.29
3ohtB-2ec5A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 9 ILE A 999
LEU A1030
ILE A 939
PHE A1037
GLY A 911
 None
 1.29A 3sj4X-2ec5A:
undetectable		 3sj4X-2ec5A:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		3 / 3 SER A 960
ASP A 967
ASP A 974
 None
 0.83A 3uj7A-2ec5A:
undetectable		 3uj7A-2ec5A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 LEU A 694
GLU A 866
ALA A 711
GLU A 701
ARG A1054
 None
 1.48A 4cpzA-2ec5A:
undetectable		 4cpzA-2ec5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 1.02A 4dfrB-2ec5A:
2.2		 4dfrB-2ec5A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 0.95A 4ej1A-2ec5A:
undetectable		 4ej1A-2ec5A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 0.91A 4fhbA-2ec5A:
undetectable		 4fhbA-2ec5A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 8 ILE A 999
LEU A1030
ILE A 939
PHE A1037
GLY A 911
 None
 1.21A 4hb6A-2ec5A:
undetectable		 4hb6A-2ec5A:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 8 ILE A 999
LEU A1030
ILE A 939
PHE A1037
GLY A 911
 None
 1.20A 4hb8A-2ec5A:
undetectable		 4hb8A-2ec5A:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA506_0
(RNA POLYMERASE
3D-POL)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		3 / 3 VAL A1038
GLY A 911
LYS A1036
 None
 0.77A 4k50A-2ec5A:
2.5		 4k50A-2ec5A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		3 / 3 VAL A1038
GLY A 911
LYS A1036
 None
 0.77A 4k50I-2ec5A:
2.5		 4k50I-2ec5A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 10 LEU A 664
LEU A 668
LEU A 695
LYS A 617
ILE A 621
 None
 1.29A 4mk4A-2ec5A:
undetectable		 4mk4A-2ec5A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 LEU A1176
MET A1179
ILE A1235
LYS A1153
ILE A1148
 None
 1.10A 4o2bB-2ec5A:
undetectable		 4o2bB-2ec5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 0.93A 4p3rA-2ec5A:
2.2		 4p3rA-2ec5A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		4 / 6 THR A 710
GLU A 701
THR A 697
LEU A 676
 None
 1.08A 4pgfA-2ec5A:
undetectable		 4pgfA-2ec5A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 0.90A 4pssA-2ec5A:
undetectable		 4pssA-2ec5A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 TYR A1018
GLY A1000
ILE A1023
ILE A 941
ALA A1041
 None
 1.14A 4qtuB-2ec5A:
undetectable		 4qtuB-2ec5A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		4 / 8 ILE A 749
LEU A 780
MET A 834
PHE A 752
 None
 0.91A 4r38B-2ec5A:
undetectable		 4r38B-2ec5A:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		4 / 5 SER A 688
GLY A 689
ARG A 851
GLU A 639
 None
 1.32A 4r82A-2ec5A:
undetectable
4r82B-2ec5A:
undetectable		 4r82A-2ec5A:
14.68
4r82B-2ec5A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 8 ALA A 691
ALA A 690
ILE A 683
ALA A 711
LEU A 718
 None
 1.21A 4v1fA-2ec5A:
undetectable
4v1fB-2ec5A:
undetectable		 4v1fA-2ec5A:
9.04
4v1fB-2ec5A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		4 / 6 THR A1049
LEU A1045
ASP A1042
LEU A1059
 None
 0.83A 4wozA-2ec5A:
undetectable
4wozB-2ec5A:
undetectable		 4wozA-2ec5A:
18.21
4wozB-2ec5A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		4 / 5 LEU A1045
ASP A1042
LEU A1059
THR A1049
 None
 0.84A 4wozF-2ec5A:
undetectable
4wozH-2ec5A:
undetectable		 4wozF-2ec5A:
18.21
4wozH-2ec5A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 0.93A 4x5gB-2ec5A:
undetectable		 4x5gB-2ec5A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		3 / 3 VAL A1240
TYR A1260
ALA A1187
 None
 0.56A 4ybnA-2ec5A:
undetectable		 4ybnA-2ec5A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		3 / 3 SER A 874
LEU A1016
MET A1056
 None
 0.62A 5ikrB-2ec5A:
undetectable		 5ikrB-2ec5A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 LEU A1176
MET A1179
ILE A1235
LYS A1153
ILE A1148
 None
 1.07A 5mioB-2ec5A:
undetectable		 5mioB-2ec5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 LEU A1059
ILE A1022
GLY A1020
THR A 872
LEU A1046
 None
 0.94A 5nfjA-2ec5A:
undetectable		 5nfjA-2ec5A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		3 / 3 GLU A 609
TYR A 611
ARG A 653
 None
 0.82A 5uunB-2ec5A:
undetectable		 5uunB-2ec5A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 7 GLY A 586
LEU A 587
LEU A 596
LEU A 668
ILE A 641
 None
 1.28A 5vkqA-2ec5A:
4.1
5vkqB-2ec5A:
3.2		 5vkqA-2ec5A:
17.85
5vkqB-2ec5A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 8 GLY A 586
LEU A 587
LEU A 596
LEU A 668
ILE A 641
 None
 1.23A 5vkqB-2ec5A:
3.2
5vkqC-2ec5A:
4.1		 5vkqB-2ec5A:
17.85
5vkqC-2ec5A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		4 / 8 GLY A 689
GLU A 639
ILE A 683
GLN A 719
 None
 1.05A 5vlmD-2ec5A:
2.2		 5vlmD-2ec5A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		4 / 5 MET A 789
TYR A 824
GLY A 822
GLY A 821
 None
 1.18A 5x7pA-2ec5A:
undetectable		 5x7pA-2ec5A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 0.87A 5z6jA-2ec5A:
undetectable		 5z6jA-2ec5A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 12 ILE A 749
LEU A 781
ILE A 802
LEU A 835
ILE A 746
 None
 0.85A 5z6kA-2ec5A:
2.2		 5z6kA-2ec5A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		3 / 3 ASN A 625
VAL A 590
HIS A 622
 None
 0.75A 6a5yD-2ec5A:
undetectable		 6a5yD-2ec5A:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		3 / 3 HIS A1228
HIS A1223
ARG A1125
 None
 0.98A 6b58A-2ec5A:
3.9		 6b58A-2ec5A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		3 / 3 TYR A 611
ALA A 656
LEU A 596
 None
 0.67A 6d9kF-2ec5A:
undetectable		 6d9kF-2ec5A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_E_DZPE502_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT BETA-3)		 2ec5 DERMONECROTIC TOXIN
(Pasteurella
multocida) 		5 / 10 MET A1056
LEU A1045
ASN A1021
LEU A 864
MET A 865
 None
 1.42A 6hupD-2ec5A:
0.0
6hupE-2ec5A:
3.8		 6hupD-2ec5A:
7.33
6hupE-2ec5A:
7.42