SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ecr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 2ecr FLAVIN REDUCTASE
COMPONENT (HPAC) OF
4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE
(Thermus
thermophilus) 		5 / 12 LEU A  70
GLU A  92
VAL A 102
GLY A  98
GLY A 129
 None
 0.93A 1etrH-2ecrA:
undetectable		 1etrH-2ecrA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2ecr FLAVIN REDUCTASE
COMPONENT (HPAC) OF
4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE
(Thermus
thermophilus) 		4 / 8 GLY A  15
VAL A 136
LEU A 145
PRO A 134
 None
 0.99A 3bgdB-2ecrA:
undetectable		 3bgdB-2ecrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ecr FLAVIN REDUCTASE
COMPONENT (HPAC) OF
4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE
(Thermus
thermophilus) 		4 / 5 VAL A  16
LEU A  70
TYR A 142
ALA A  82
 None
 0.98A 3n8yB-2ecrA:
undetectable		 3n8yB-2ecrA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2ecr FLAVIN REDUCTASE
COMPONENT (HPAC) OF
4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE
(Thermus
thermophilus) 		3 / 3 SER A  37
ALA A  46
VAL A 120
 None
 0.67A 4o2bC-2ecrA:
undetectable		 4o2bC-2ecrA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2ecr FLAVIN REDUCTASE
COMPONENT (HPAC) OF
4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE
(Thermus
thermophilus) 		3 / 3 PRO A  57
VAL A  49
HIS A 116
 None
 0.75A 4pevC-2ecrA:
undetectable		 4pevC-2ecrA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 2ecr FLAVIN REDUCTASE
COMPONENT (HPAC) OF
4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE
(Thermus
thermophilus) 		3 / 3 ARG A  84
TYR A 142
GLU A  79
 None
 0.68A 4zzbE-2ecrA:
undetectable		 4zzbE-2ecrA:
17.83