SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ed7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 2ed7 NETRIN RECEPTOR DCC
(Homo
sapiens) 		5 / 12 VAL A  24
ASP A  23
LEU A  81
SER A 103
PRO A 105
 None
 1.32A 1ia0B-2ed7A:
undetectable		 1ia0B-2ed7A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 2ed7 NETRIN RECEPTOR DCC
(Homo
sapiens) 		5 / 12 VAL A  24
ASP A  23
LEU A  81
SER A 103
PRO A 105
 None
 1.33A 1tubB-2ed7A:
undetectable		 1tubB-2ed7A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 2ed7 NETRIN RECEPTOR DCC
(Homo
sapiens) 		3 / 3 ALA A  44
VAL A  16
TRP A  97
 None
 0.97A 2izqA-2ed7A:
undetectable
2izqB-2ed7A:
undetectable		 2izqA-2ed7A:
10.20
2izqB-2ed7A:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2ed7 NETRIN RECEPTOR DCC
(Homo
sapiens) 		4 / 7 LEU A  74
PRO A  21
ALA A  93
ALA A  44
 None
 0.96A 2vcvG-2ed7A:
undetectable		 2vcvG-2ed7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2ed7 NETRIN RECEPTOR DCC
(Homo
sapiens) 		4 / 6 LEU A  74
PRO A  21
ALA A  93
ALA A  44
 None
 0.98A 2vcvK-2ed7A:
undetectable		 2vcvK-2ed7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 2ed7 NETRIN RECEPTOR DCC
(Homo
sapiens) 		5 / 11 ILE A 106
SER A  37
VAL A  91
PHE A  89
VAL A  53
 None
 1.21A 3rf4A-2ed7A:
undetectable
3rf4B-2ed7A:
undetectable		 3rf4A-2ed7A:
22.31
3rf4B-2ed7A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2ed7 NETRIN RECEPTOR DCC
(Homo
sapiens) 		4 / 4 GLY A  79
ARG A  64
ASN A  80
LEU A  81
 None
 1.25A 6b58A-2ed7A:
undetectable		 6b58A-2ed7A:
13.08