SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ee4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 2ee4 RHO GTPASE
ACTIVATING PROTEIN 5
VARIANT
(Homo
sapiens) 		5 / 11 LEU A 162
ILE A 142
PHE A 166
GLU A  36
LEU A  87
 None
 1.42A 2v0mA-2ee4A:
undetectable		 2v0mA-2ee4A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2ee4 RHO GTPASE
ACTIVATING PROTEIN 5
VARIANT
(Homo
sapiens) 		4 / 4 SER A   2
GLY A   1
GLY A   4
GLY A  14
 None
 0.73A 3bogB-2ee4A:
undetectable
3bogD-2ee4A:
undetectable		 3bogB-2ee4A:
undetectable
3bogD-2ee4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 2ee4 RHO GTPASE
ACTIVATING PROTEIN 5
VARIANT
(Homo
sapiens) 		3 / 3 ARG A 147
VAL A  80
THR A  41
 None
 0.87A 3pwrA-2ee4A:
undetectable		 3pwrA-2ee4A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 2ee4 RHO GTPASE
ACTIVATING PROTEIN 5
VARIANT
(Homo
sapiens) 		4 / 6 PHE A 175
TYR A 101
HIS A 187
THR A 184
 None
 1.31A 4paeA-2ee4A:
undetectable		 4paeA-2ee4A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2ee4 RHO GTPASE
ACTIVATING PROTEIN 5
VARIANT
(Homo
sapiens) 		4 / 8 LEU A  73
ILE A  61
ALA A  86
PHE A  30
 None
 0.75A 5m0oC-2ee4A:
undetectable		 5m0oC-2ee4A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ee4 RHO GTPASE
ACTIVATING PROTEIN 5
VARIANT
(Homo
sapiens) 		5 / 12 PHE A  90
HIS A  69
ILE A  38
LEU A  20
TYR A  12
 None
 1.42A 5ycpA-2ee4A:
undetectable		 5ycpA-2ee4A:
19.66