SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eeg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2eeg PDZ AND LIM DOMAIN
PROTEIN 4
(Homo
sapiens) 		5 / 11 ALA A  48
LEU A  83
ILE A  56
LEU A  24
ILE A  36
 None
 1.03A 1dhiB-2eegA:
undetectable		 1dhiB-2eegA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2eeg PDZ AND LIM DOMAIN
PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A  48
LEU A  83
ILE A  56
LEU A  24
ILE A  36
 None
 1.05A 1draB-2eegA:
undetectable		 1draB-2eegA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2eeg PDZ AND LIM DOMAIN
PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A  48
LEU A  83
ILE A  56
LEU A  24
ILE A  36
 None
 1.00A 1drbB-2eegA:
undetectable		 1drbB-2eegA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2eeg PDZ AND LIM DOMAIN
PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A  48
LEU A  83
ILE A  56
LEU A  24
ILE A  36
 None
 1.04A 1ra3A-2eegA:
undetectable		 1ra3A-2eegA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 2eeg PDZ AND LIM DOMAIN
PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A  48
LEU A  83
ILE A  56
LEU A  24
ILE A  36
 None
 1.08A 2drcB-2eegA:
undetectable		 2drcB-2eegA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2eeg PDZ AND LIM DOMAIN
PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A  48
LEU A  83
ILE A  56
LEU A  24
ILE A  36
 None
 1.07A 3drcB-2eegA:
undetectable		 3drcB-2eegA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 2eeg PDZ AND LIM DOMAIN
PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A  48
LEU A  83
ILE A  56
LEU A  24
ILE A  36
 None
 1.08A 4dfrB-2eegA:
undetectable		 4dfrB-2eegA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2eeg PDZ AND LIM DOMAIN
PROTEIN 4
(Homo
sapiens) 		3 / 3 HIS A  40
VAL A  12
LEU A  14
 None
 0.66A 4m2vA-2eegA:
undetectable		 4m2vA-2eegA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2eeg PDZ AND LIM DOMAIN
PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A  48
LEU A  83
ILE A  56
LEU A  24
ILE A  36
 None
 1.08A 4nx6A-2eegA:
undetectable		 4nx6A-2eegA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 2eeg PDZ AND LIM DOMAIN
PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A  48
LEU A  83
ILE A  56
LEU A  24
ILE A  36
 None
 1.07A 4nx7A-2eegA:
undetectable		 4nx7A-2eegA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2eeg PDZ AND LIM DOMAIN
PROTEIN 4
(Homo
sapiens) 		5 / 12 ALA A  48
LEU A  83
ILE A  56
LEU A  24
ILE A  36
 None
 1.06A 4pstA-2eegA:
undetectable		 4pstA-2eegA:
21.19