SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eek'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 2eek TRYPSIN-1
(Gadus
morhua) 		8 / 8 HIS A  57
ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
BEN  A 301 (-2.7A)
BEN  A 301 (-2.8A)
BEN  A 301 (-4.1A)
BEN  A 301 (-3.4A)
None
BEN  A 301 ( 3.8A)
BEN  A 301 (-3.2A)
 0.57A 1aq7A-2eekA:
40.5		 1aq7A-2eekA:
62.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 2eek TRYPSIN-1
(Gadus
morhua) 		6 / 9 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 BEN  A 301 (-2.7A)
BEN  A 301 (-3.4A)
None
None
BEN  A 301 ( 3.8A)
BEN  A 301 (-3.2A)
 0.29A 1bcuH-2eekA:
18.0		 1bcuH-2eekA:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 2eek TRYPSIN-1
(Gadus
morhua) 		5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
BEN  A 301 (-2.7A)
BEN  A 301 (-3.4A)
None
BEN  A 301 (-3.2A)
 0.37A 1dwcH-2eekA:
33.1		 1dwcH-2eekA:
38.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 2eek TRYPSIN-1
(Gadus
morhua) 		5 / 9 LEU A 105
ILE A 106
LEU A 209
VAL A  31
GLY A  44
 None
 1.26A 1e7aB-2eekA:
undetectable		 1e7aB-2eekA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 2eek TRYPSIN-1
(Gadus
morhua) 		5 / 9 LEU A 163
ILE A 162
VAL A 199
GLY A 211
LEU A 160
 None
 0.99A 1e7aB-2eekA:
undetectable		 1e7aB-2eekA:
16.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 2eek TRYPSIN-1
(Gadus
morhua) 		7 / 12 HIS A  57
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
BEN  A 301 (-2.7A)
BEN  A 301 (-3.4A)
None
None
BEN  A 301 ( 3.8A)
BEN  A 301 (-3.2A)
 0.43A 1etrH-2eekA:
33.0		 1etrH-2eekA:
38.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2eek TRYPSIN-1
(Gadus
morhua) 		6 / 8 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 301 (-2.7A)
BEN  A 301 (-2.8A)
BEN  A 301 (-3.4A)
None
BEN  A 301 ( 3.8A)
BEN  A 301 (-3.2A)
 0.30A 1f5lA-2eekA:
15.7		 1f5lA-2eekA:
34.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 2eek TRYPSIN-1
(Gadus
morhua) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 301 (-2.7A)
BEN  A 301 (-2.8A)
BEN  A 301 (-3.4A)
None
BEN  A 301 ( 3.8A)
BEN  A 301 (-3.2A)
 0.25A 1tnlA-2eekA:
40.3		 1tnlA-2eekA:
62.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VID_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 2eek TRYPSIN-1
(Gadus
morhua) 		4 / 5 SER A 171
GLU A 186
TYR A 184
ASP A 167
 None
 1.25A 1vidA-2eekA:
undetectable		 1vidA-2eekA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 2eek TRYPSIN-1
(Gadus
morhua) 		5 / 11 LEU A 163
ILE A 162
VAL A 199
GLY A 211
LEU A 160
 None
 0.99A 2bxeA-2eekA:
undetectable		 2bxeA-2eekA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 2eek TRYPSIN-1
(Gadus
morhua) 		5 / 12 LEU A 163
ILE A 162
VAL A 199
GLY A 211
LEU A 160
 None
 0.97A 2bxeB-2eekA:
undetectable		 2bxeB-2eekA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2eek TRYPSIN-1
(Gadus
morhua) 		5 / 5 LEU A 155
ILE A  73
SER A  32
GLY A  43
HIS A  29
 None
 1.08A 2otfA-2eekA:
undetectable		 2otfA-2eekA:
18.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 2eek TRYPSIN-1
(Gadus
morhua) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 301 (-2.7A)
BEN  A 301 (-2.8A)
BEN  A 301 (-3.4A)
None
BEN  A 301 ( 3.8A)
BEN  A 301 (-3.2A)
 0.21A 2otvA-2eekA:
40.2		 2otvA-2eekA:
62.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 2eek TRYPSIN-1
(Gadus
morhua) 		7 / 12 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 BEN  A 301 (-2.7A)
BEN  A 301 (-3.4A)
None
None
BEN  A 301 ( 3.8A)
BEN  A 301 (-3.2A)
None
 0.31A 2p16A-2eekA:
34.9		 2p16A-2eekA:
35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2eek TRYPSIN-1
(Gadus
morhua) 		6 / 8 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 BEN  A 301 (-2.7A)
BEN  A 301 (-2.8A)
BEN  A 301 (-3.4A)
None
BEN  A 301 ( 3.8A)
BEN  A 301 (-3.2A)
 0.25A 2vinA-2eekA:
16.4		 2vinA-2eekA:
34.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 2eek TRYPSIN-1
(Gadus
morhua) 		8 / 12 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 BEN  A 301 (-2.7A)
BEN  A 301 (-3.4A)
None
None
BEN  A 301 ( 3.8A)
None
BEN  A 301 (-3.2A)
None
 0.35A 2w26A-2eekA:
13.9		 2w26A-2eekA:
35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 2eek TRYPSIN-1
(Gadus
morhua) 		8 / 11 HIS A  57
ASP A 189
SER A 190
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
BEN  A 301 (-2.7A)
BEN  A 301 (-2.8A)
BEN  A 301 (-4.1A)
BEN  A 301 (-3.4A)
None
BEN  A 301 ( 3.8A)
BEN  A 301 (-3.2A)
 0.42A 3gy3A-2eekA:
40.6		 3gy3A-2eekA:
62.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 2eek TRYPSIN-1
(Gadus
morhua) 		6 / 6 SER A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 BEN  A 301 (-2.8A)
BEN  A 301 (-3.4A)
None
None
BEN  A 301 ( 3.8A)
BEN  A 301 (-3.2A)
 0.24A 3rxfA-2eekA:
40.8		 3rxfA-2eekA:
62.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 2eek TRYPSIN-1
(Gadus
morhua) 		5 / 5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 BEN  A 301 (-2.7A)
BEN  A 301 (-2.8A)
BEN  A 301 (-3.4A)
None
BEN  A 301 (-3.2A)
 0.28A 3rxhA-2eekA:
40.8		 3rxhA-2eekA:
62.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2eek TRYPSIN-1
(Gadus
morhua) 		4 / 6 PHE A 181
ALA A 183
PRO A 198
VAL A 138
 None
 0.91A 4dubA-2eekA:
undetectable		 4dubA-2eekA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2eek TRYPSIN-1
(Gadus
morhua) 		4 / 6 PHE A 181
ALA A 183
PRO A 198
VAL A 138
 None
 0.87A 4dubB-2eekA:
undetectable		 4dubB-2eekA:
18.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2eek TRYPSIN-1
(Gadus
morhua) 		4 / 5 HIS A  57
GLN A 192
GLY A 193
SER A 195
 None
BEN  A 301 (-4.1A)
None
BEN  A 301 (-3.4A)
 0.86A 4fu8A-2eekA:
15.5		 4fu8A-2eekA:
35.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 2eek TRYPSIN-1
(Gadus
morhua) 		5 / 12 HIS A  57
ASP A 189
VAL A 213
TRP A 215
GLY A 226
 None
BEN  A 301 (-2.7A)
None
None
BEN  A 301 (-3.2A)
 0.29A 4hfpD-2eekA:
33.0		 4hfpD-2eekA:
37.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 2eek TRYPSIN-1
(Gadus
morhua) 		5 / 12 GLY A  18
GLY A  19
LEU A 160
SER A 159
VAL A 213
 None
 0.96A 4htfA-2eekA:
undetectable		 4htfA-2eekA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 2eek TRYPSIN-1
(Gadus
morhua) 		5 / 12 VAL A 231
GLY A  44
ILE A 103
LEU A 105
LEU A  46
 None
 0.95A 4qdjA-2eekA:
undetectable		 4qdjA-2eekA:
17.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 2eek TRYPSIN-1
(Gadus
morhua) 		5 / 12 HIS A  57
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
None
None
BEN  A 301 ( 3.8A)
BEN  A 301 (-3.2A)
 0.29A 4rn6B-2eekA:
27.8		 4rn6B-2eekA:
37.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 2eek TRYPSIN-1
(Gadus
morhua) 		4 / 5 SER A 171
GLU A 186
TYR A 184
ASP A 167
 None
 1.32A 5fhrA-2eekA:
undetectable		 5fhrA-2eekA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 2eek TRYPSIN-1
(Gadus
morhua) 		5 / 10 PRO A 124
ILE A 162
LEU A 209
LEU A 234
PHE A 181
 None
 1.40A 5tixB-2eekA:
undetectable		 5tixB-2eekA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2eek TRYPSIN-1
(Gadus
morhua) 		5 / 12 VAL A  88
ALA A 120
VAL A 212
LEU A  33
VAL A  65
 None
 1.23A 5tudD-2eekA:
undetectable		 5tudD-2eekA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_E_EY4E500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2eek TRYPSIN-1
(Gadus
morhua) 		4 / 8 GLN A 156
VAL A  17
ALA A 221
TYR A 184
 None
 0.90A 6cduD-2eekA:
undetectable
6cduE-2eekA:
undetectable		 6cduD-2eekA:
18.45
6cduE-2eekA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 2eek TRYPSIN-1
(Gadus
morhua) 		4 / 7 GLN A 156
VAL A  17
ALA A 221
TYR A 184
 None
 0.96A 6cduH-2eekA:
undetectable
6cduI-2eekA:
undetectable		 6cduH-2eekA:
18.45
6cduI-2eekA:
18.45