SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2een'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 2een HYPOTHETICAL PROTEIN
PH1819
(Pyrococcus
horikoshii) 		4 / 6 ASP A  12
PHE A  15
GLU A 126
GLU A 112
 None
 1.30A 2dttB-2eenA:
undetectable
2dttC-2eenA:
undetectable		 2dttB-2eenA:
23.12
2dttC-2eenA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 2een HYPOTHETICAL PROTEIN
PH1819
(Pyrococcus
horikoshii) 		5 / 10 GLY A   8
GLU A 166
LEU A   6
LEU A 157
ILE A 136
 None
 1.33A 3kvrB-2eenA:
undetectable		 3kvrB-2eenA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 2een HYPOTHETICAL PROTEIN
PH1819
(Pyrococcus
horikoshii) 		5 / 12 ARG A 111
PHE A 165
ALA A  10
ASP A 125
LEU A 124
 None
 1.36A 3lcvB-2eenA:
undetectable		 3lcvB-2eenA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 2een HYPOTHETICAL PROTEIN
PH1819
(Pyrococcus
horikoshii) 		5 / 9 GLY A   8
GLU A 166
LEU A   6
LEU A 157
ILE A 136
 None
 1.43A 3nbqA-2eenA:
undetectable		 3nbqA-2eenA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC608_0
(GBAA_1210 PROTEIN)		 2een HYPOTHETICAL PROTEIN
PH1819
(Pyrococcus
horikoshii) 		4 / 5 GLU A   3
ARG A  52
LYS A  67
GLU A 137
 None
 1.09A 3tj7C-2eenA:
14.2		 3tj7C-2eenA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC608_0
(GBAA_1210 PROTEIN)		 2een HYPOTHETICAL PROTEIN
PH1819
(Pyrococcus
horikoshii) 		5 / 5 GLU A   5
ARG A  52
LYS A  67
ARG A 111
GLU A 135
 None
 0.89A 3tj7C-2eenA:
14.2		 3tj7C-2eenA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC608_0
(GBAA_1210 PROTEIN)		 2een HYPOTHETICAL PROTEIN
PH1819
(Pyrococcus
horikoshii) 		4 / 5 GLU A 135
ARG A  50
LYS A 109
GLU A   5
 None
 1.28A 3tj7C-2eenA:
14.2		 3tj7C-2eenA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2een HYPOTHETICAL PROTEIN
PH1819
(Pyrococcus
horikoshii) 		3 / 3 ASP A 125
ARG A  52
LYS A 109
 None
 1.24A 3wipG-2eenA:
undetectable		 3wipG-2eenA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2een HYPOTHETICAL PROTEIN
PH1819
(Pyrococcus
horikoshii) 		5 / 12 THR A 138
VAL A 140
ASP A  72
ILE A 146
GLU A 145
 None
 1.34A 4i41A-2eenA:
undetectable		 4i41A-2eenA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2een HYPOTHETICAL PROTEIN
PH1819
(Pyrococcus
horikoshii) 		5 / 11 ALA A  48
LEU A  49
GLU A  82
LEU A  64
LEU A  96
 None
 0.92A 4wg0C-2eenA:
undetectable
4wg0D-2eenA:
undetectable
4wg0E-2eenA:
undetectable		 4wg0C-2eenA:
7.59
4wg0D-2eenA:
7.59
4wg0E-2eenA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2een HYPOTHETICAL PROTEIN
PH1819
(Pyrococcus
horikoshii) 		5 / 11 ALA A  48
LEU A  49
GLU A  82
LEU A  64
LEU A  96
 None
 0.92A 4wg0E-2eenA:
undetectable
4wg0F-2eenA:
undetectable
4wg0G-2eenA:
undetectable		 4wg0E-2eenA:
7.59
4wg0F-2eenA:
7.59
4wg0G-2eenA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2een HYPOTHETICAL PROTEIN
PH1819
(Pyrococcus
horikoshii) 		5 / 11 LEU A  96
GLU A  82
LEU A  64
ALA A  48
LEU A  49
 None
 1.00A 4wg0H-2eenA:
undetectable
4wg0I-2eenA:
undetectable
4wg0J-2eenA:
undetectable		 4wg0H-2eenA:
7.59
4wg0I-2eenA:
7.59
4wg0J-2eenA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2een HYPOTHETICAL PROTEIN
PH1819
(Pyrococcus
horikoshii) 		5 / 11 ALA A  48
LEU A  49
GLU A  82
LEU A  64
LEU A  96
 None
 0.85A 4wg0K-2eenA:
undetectable
4wg0L-2eenA:
undetectable
4wg0M-2eenA:
undetectable		 4wg0K-2eenA:
7.59
4wg0L-2eenA:
7.59
4wg0M-2eenA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2een HYPOTHETICAL PROTEIN
PH1819
(Pyrococcus
horikoshii) 		3 / 3 TYR A 170
ARG A 111
LYS A 109
 None
 1.29A 4wq5B-2eenA:
undetectable		 4wq5B-2eenA:
19.35