SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eer'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 8 THR A 319
GLY A 182
ALA A 208
THR A 185
None
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
0.73A 1c9sI-2eerA:
undetectable
1c9sJ-2eerA:
undetectable
1c9sI-2eerA:
13.02
1c9sJ-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_T_TRPT81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 7 GLY A 182
ALA A 208
THR A 185
THR A 319
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
None
0.80A 1c9sT-2eerA:
undetectable
1c9sU-2eerA:
undetectable
1c9sT-2eerA:
13.02
1c9sU-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
5 / 11 PRO A 151
LEU A 152
VAL A 314
GLY A 312
LEU A 141
None
1.38A 1fkpA-2eerA:
2.7
1fkpA-2eerA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 7 GLY A 182
ALA A 208
THR A 185
THR A 319
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
None
0.80A 1gtfL-2eerA:
undetectable
1gtfM-2eerA:
undetectable
1gtfL-2eerA:
13.02
1gtfM-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 8 GLY A 182
ALA A 208
THR A 185
THR A 319
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
None
0.78A 1gtfN-2eerA:
undetectable
1gtfO-2eerA:
undetectable
1gtfN-2eerA:
13.02
1gtfO-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 7 GLY A 182
ALA A 208
THR A 185
THR A 319
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
None
0.77A 1gtnA-2eerA:
undetectable
1gtnK-2eerA:
undetectable
1gtnA-2eerA:
13.02
1gtnK-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 8 THR A 319
GLY A 182
ALA A 208
THR A 185
None
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
0.72A 1gtnA-2eerA:
undetectable
1gtnB-2eerA:
undetectable
1gtnA-2eerA:
13.02
1gtnB-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 8 THR A 319
GLY A 182
ALA A 208
THR A 185
None
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
0.72A 1gtnE-2eerA:
undetectable
1gtnF-2eerA:
undetectable
1gtnE-2eerA:
13.02
1gtnF-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 8 THR A 319
GLY A 182
ALA A 208
THR A 185
None
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
0.74A 1gtnI-2eerA:
undetectable
1gtnJ-2eerA:
undetectable
1gtnI-2eerA:
13.02
1gtnJ-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
5 / 11 ILE A 331
ASN A 333
LEU A 345
GLY A  36
MET A 322
None
1.24A 1hvyC-2eerA:
undetectable
1hvyC-2eerA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 5 GLY A 265
GLN A 290
VAL A 268
SER A 167
None
1.15A 1p6kB-2eerA:
undetectable
1p6kB-2eerA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 5 GLY A 265
GLN A 290
VAL A 268
SER A 167
None
1.17A 1rs6B-2eerA:
undetectable
1rs6B-2eerA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 8 GLY A 182
ALA A 208
THR A 185
THR A 319
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
None
0.71A 1utdB-2eerA:
undetectable
1utdC-2eerA:
undetectable
1utdB-2eerA:
13.02
1utdC-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 8 GLY A 182
ALA A 208
THR A 185
THR A 319
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
None
0.73A 1utdF-2eerA:
undetectable
1utdG-2eerA:
undetectable
1utdF-2eerA:
13.02
1utdG-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 8 GLY A 182
ALA A 208
THR A 185
THR A 319
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
None
0.74A 1utdI-2eerA:
undetectable
1utdJ-2eerA:
undetectable
1utdI-2eerA:
13.02
1utdJ-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 8 GLY A 182
ALA A 208
THR A 185
THR A 319
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
None
0.73A 1utdJ-2eerA:
undetectable
1utdK-2eerA:
undetectable
1utdJ-2eerA:
13.02
1utdK-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 5 GLY A 265
GLN A 290
VAL A 268
SER A 167
None
1.14A 1zzuB-2eerA:
undetectable
1zzuB-2eerA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
3 / 3 ARG A 342
VAL A 314
GLY A 304
NAD  A 401 (-3.0A)
None
None
0.52A 2avvE-2eerA:
undetectable
2avvE-2eerA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
5 / 12 VAL A 130
GLY A 119
TYR A 122
SER A  40
HIS A  68
None
None
None
NAD  A 401 (-2.9A)
None
1.31A 2zthA-2eerA:
8.3
2zthA-2eerA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
5 / 12 PHE A  49
LEU A  52
GLY A 271
ASN A 248
PHE A 291
None
None
NAD  A 401 (-3.5A)
NAD  A 401 (-3.4A)
None
1.35A 2zznB-2eerA:
6.7
2zznB-2eerA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
5 / 10 ALA A 193
LEU A 308
ILE A 305
THR A 153
VAL A 318
None
1.43A 3r9cA-2eerA:
undetectable
3r9cA-2eerA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_1
(HIV-1 PROTEASE)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 8 GLY A 216
ALA A 217
ASP A 218
ILE A 190
None
0.70A 3so9A-2eerA:
undetectable
3so9A-2eerA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
6 / 10 ALA A  91
ILE A  30
VAL A 130
ALA A  35
ALA A  34
ILE A  32
None
1.13A 4lbgA-2eerA:
3.8
4lbgA-2eerA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
5 / 9 ALA A  91
ILE A  30
VAL A 130
ALA A  35
ALA A  34
None
1.09A 4lbgB-2eerA:
3.8
4lbgB-2eerA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 5 VAL A 132
LEU A 138
ILE A  30
LEU A  29
None
0.83A 4mghA-2eerA:
3.1
4mghA-2eerA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 6 LEU A 131
TYR A 129
PRO A  21
GLU A  76
None
1.09A 4z4gA-2eerA:
undetectable
4z4gA-2eerA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 8 THR A 319
GLY A 182
ALA A 208
THR A 185
None
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
0.79A 5eevL-2eerA:
undetectable
5eevV-2eerA:
undetectable
5eevL-2eerA:
13.02
5eevV-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 8 THR A 319
GLY A 182
ALA A 208
THR A 185
None
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
0.79A 5eewL-2eerA:
undetectable
5eewV-2eerA:
undetectable
5eewL-2eerA:
13.02
5eewV-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 8 THR A 319
GLY A 182
ALA A 208
THR A 185
None
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
0.78A 5eezL-2eerA:
undetectable
5eezV-2eerA:
undetectable
5eezL-2eerA:
13.02
5eezV-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 8 THR A 319
GLY A 182
ALA A 208
THR A 185
None
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
0.79A 5ef1L-2eerA:
undetectable
5ef1V-2eerA:
undetectable
5ef1L-2eerA:
13.02
5ef1V-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 8 THR A 319
GLY A 182
ALA A 208
THR A 185
None
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
0.79A 5ef2L-2eerA:
undetectable
5ef2V-2eerA:
undetectable
5ef2L-2eerA:
13.02
5ef2V-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 8 THR A 319
GLY A 182
ALA A 208
THR A 185
None
NAD  A 401 (-3.7A)
NAD  A 401 ( 4.4A)
None
0.79A 5ef3L-2eerA:
undetectable
5ef3V-2eerA:
undetectable
5ef3L-2eerA:
13.02
5ef3V-2eerA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
3 / 3 ALA A 330
ASN A 333
LEU A 334
None
None
NAD  A 401 (-3.6A)
0.34A 5i1nB-2eerA:
undetectable
5i1nB-2eerA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
3 / 3 ALA A 330
ASN A 333
LEU A 334
None
None
NAD  A 401 (-3.6A)
0.37A 5i1oA-2eerA:
undetectable
5i1oA-2eerA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD2_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 4 GLY A  97
CYH A 112
ARG A 116
GLY A  99
ZN  A 501 ( 4.6A)
ZN  A 501 (-2.3A)
None
ZN  A 501 ( 4.6A)
1.01A 5inzA-2eerA:
undetectable
5inzC-2eerA:
undetectable
5inzD-2eerA:
undetectable
5inzA-2eerA:
3.53
5inzC-2eerA:
3.53
5inzD-2eerA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)
2eer NAD-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Sulfurisphaera
tokodaii)
4 / 5 GLY A 265
GLN A 290
VAL A 268
SER A 167
None
1.20A 5vunA-2eerA:
undetectable
5vunA-2eerA:
21.35