SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eez'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2eez ALANINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 LEU A 253
VAL A 227
LEU A 233
ALA A 260
 None
 0.72A 1fiqC-2eezA:
undetectable		 1fiqC-2eezA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 2eez ALANINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A  21
GLY A  22
VAL A 319
LEU A 316
LEU A  26
 None
 0.90A 1mx1D-2eezA:
2.4		 1mx1D-2eezA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 2eez ALANINE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 THR A 308
THR A 306
PRO A 304
 None
 0.83A 1qfiB-2eezA:
undetectable		 1qfiB-2eezA:
2.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 2eez ALANINE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 THR A 306
PRO A 304
THR A 308
 None
 0.71A 209dC-2eezA:
undetectable		 209dC-2eezA:
2.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 2eez ALANINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A 290
LEU A 232
ASP A 231
ARG A 154
PHE A 146
 None
 1.48A 2b9eA-2eezA:
6.6		 2b9eA-2eezA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2eez ALANINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A 259
GLY A 155
GLU A 258
ILE A 262
ASP A 231
 None
 0.90A 2oxtC-2eezA:
4.5		 2oxtC-2eezA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 2eez ALANINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 THR A 315
THR A  19
VAL A   5
ILE A   3
 None
 0.98A 2qbmA-2eezA:
undetectable		 2qbmA-2eezA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2eez ALANINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 GLU A 116
HIS A 349
ASN A 341
ILE A 113
 None
 1.27A 3kp6A-2eezA:
undetectable
3kp6B-2eezA:
undetectable		 3kp6A-2eezA:
17.90
3kp6B-2eezA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 2eez ALANINE
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 PRO A 362
THR A 348
LEU A 367
 None
 0.78A 3ttrA-2eezA:
undetectable		 3ttrA-2eezA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_F_5FWF1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2eez ALANINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 GLU A   8
LYS A  71
LYS A   7
GLU A  36
 None
 1.31A 4a7tF-2eezA:
undetectable		 4a7tF-2eezA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 2eez ALANINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 MET A   1
LEU A  87
ALA A  66
VAL A  33
 None
 0.98A 4ik7A-2eezA:
undetectable		 4ik7A-2eezA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 2eez ALANINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A 259
ALA A 260
GLY A 153
GLY A 155
VAL A 156
 None
 0.89A 4o3fA-2eezA:
4.7		 4o3fA-2eezA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2eez ALANINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 ILE A 171
PHE A 146
SER A 226
ASP A 264
 None
 1.44A 4rzvB-2eezA:
undetectable		 4rzvB-2eezA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 2eez ALANINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A 173
ASP A 196
PHE A 209
ILE A 171
ALA A 181
 None
 1.33A 4wh5A-2eezA:
undetectable		 4wh5A-2eezA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_A_AZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2eez ALANINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 ASN A 298
VAL A  72
LEU A 311
THR A 312
ALA A 310
 None
 1.35A 4ygfA-2eezA:
undetectable		 4ygfA-2eezA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2eez ALANINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 ASN A 298
VAL A  72
LEU A 311
THR A 312
ALA A 310
 None
 1.41A 4yhaB-2eezA:
undetectable		 4yhaB-2eezA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2eez ALANINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 8 GLY A  21
VAL A  23
ALA A  55
LEU A  57
GLY A  40
 None
 1.15A 4zauA-2eezA:
undetectable		 4zauA-2eezA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 2eez ALANINE
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 LEU A 322
LEU A 316
PHE A  90
LEU A 127
 None
 0.96A 5gs4A-2eezA:
undetectable		 5gs4A-2eezA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 2eez ALANINE
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 MET A   1
ILE A   3
LEU A  18
LEU A 316
THR A 315
 None
 1.22A 6b52A-2eezA:
undetectable		 6b52A-2eezA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_K_BO2K301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2eez ALANINE
DEHYDROGENASE
(Thermus
thermophilus) 		6 / 11 THR A 179
ALA A 181
ALA A 135
ALA A 139
GLY A 175
ALA A 236
 None
 1.37A 6hwdK-2eezA:
undetectable
6hwdL-2eezA:
undetectable		 6hwdK-2eezA:
12.43
6hwdL-2eezA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_Y_BO2Y301_0
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2eez ALANINE
DEHYDROGENASE
(Thermus
thermophilus) 		6 / 11 THR A 179
ALA A 181
ALA A 135
ALA A 139
GLY A 175
ALA A 236
 None
 1.37A 6hwdY-2eezA:
undetectable
6hwdZ-2eezA:
undetectable		 6hwdY-2eezA:
12.43
6hwdZ-2eezA:
13.76