SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ef0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 2ef0 ORNITHINE
CARBAMOYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A  23
LEU A  26
LEU A  29
ALA A  30
LEU A 136
 None
 0.95A 1ya3C-2ef0A:
undetectable		 1ya3C-2ef0A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2ef0 ORNITHINE
CARBAMOYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 LYS A  34
ASP A 141
ASP A 220
 None
 0.96A 2br4A-2ef0A:
3.5		 2br4A-2ef0A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 2ef0 ORNITHINE
CARBAMOYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 ALA A 174
ALA A 177
LEU A 142
SER A 169
LEU A 170
 None
 1.12A 2bxeB-2ef0A:
undetectable		 2bxeB-2ef0A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2ef0 ORNITHINE
CARBAMOYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 PHE A 282
SER A 279
ALA A 263
LEU A 261
 None
 1.03A 2o01A-2ef0A:
undetectable		 2o01A-2ef0A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2ef0 ORNITHINE
CARBAMOYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 HIS A 275
GLN A 284
THR A 219
PHE A 257
 None
 0.97A 2xfhA-2ef0A:
undetectable		 2xfhA-2ef0A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2ef0 ORNITHINE
CARBAMOYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 LEU A 212
VAL A 160
ARG A 182
 None
 0.80A 3b0wB-2ef0A:
undetectable		 3b0wB-2ef0A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ef0 ORNITHINE
CARBAMOYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 GLY A 194
PRO A 191
LEU A 171
 None
 0.55A 3hcpB-2ef0A:
5.9		 3hcpB-2ef0A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ef0 ORNITHINE
CARBAMOYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 HIS A 134
VAL A 173
LEU A 299
LEU A  23
 None
 0.72A 3kk6A-2ef0A:
undetectable		 3kk6A-2ef0A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2ef0 ORNITHINE
CARBAMOYLTRANSFERASE
(Thermus
thermophilus) 		5 / 9 LEU A 179
VAL A 173
LEU A 258
ALA A 138
THR A 144
 None
 1.11A 3mdvA-2ef0A:
undetectable		 3mdvA-2ef0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2ef0 ORNITHINE
CARBAMOYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 LEU A 145
VAL A 256
TYR A 218
LEU A 179
 None
 1.03A 3v81A-2ef0A:
undetectable		 3v81A-2ef0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2ef0 ORNITHINE
CARBAMOYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 LEU A 145
VAL A 256
TYR A 218
LEU A 179
 None
 0.96A 3v81C-2ef0A:
undetectable		 3v81C-2ef0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2ef0 ORNITHINE
CARBAMOYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A  23
LEU A  26
LEU A  29
ALA A  30
LEU A 136
 None
 0.80A 4ltwA-2ef0A:
undetectable		 4ltwA-2ef0A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2ef0 ORNITHINE
CARBAMOYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 LEU A 145
VAL A 256
TYR A 218
LEU A 179
 None
 1.08A 4q0bA-2ef0A:
undetectable		 4q0bA-2ef0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 2ef0 ORNITHINE
CARBAMOYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 GLY A  19
PRO A  20
ALA A 177
 None
 0.44A 4qn9B-2ef0A:
undetectable		 4qn9B-2ef0A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2ef0 ORNITHINE
CARBAMOYLTRANSFERASE
(Thermus
thermophilus) 		4 / 7 PHE A 282
SER A 279
ALA A 263
LEU A 261
 None
 1.06A 4xk8A-2ef0A:
undetectable		 4xk8A-2ef0A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2ef0 ORNITHINE
CARBAMOYLTRANSFERASE
(Thermus
thermophilus) 		5 / 8 ALA A 216
LEU A 152
LEU A 170
TYR A 218
LEU A 179
 None
 1.42A 5jqbA-2ef0A:
undetectable
5jqbB-2ef0A:
undetectable		 5jqbA-2ef0A:
21.69
5jqbB-2ef0A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 2ef0 ORNITHINE
CARBAMOYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ASP A 162
GLY A 163
ASN A 168
LEU A 171
ALA A 201
 None
 1.31A 5kc4E-2ef0A:
undetectable		 5kc4E-2ef0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 2ef0 ORNITHINE
CARBAMOYLTRANSFERASE
(Thermus
thermophilus) 		6 / 12 PHE A 149
GLU A 254
ALA A 214
GLY A 213
LEU A 179
ARG A 278
 None
 1.02A 5w7pA-2ef0A:
4.7		 5w7pA-2ef0A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2ef0 ORNITHINE
CARBAMOYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 VAL A 157
ALA A 216
LEU A 179
LEU A 152
LEU A 170
 None
 0.89A 6f5uA-2ef0A:
undetectable
6f5uB-2ef0A:
undetectable		 6f5uA-2ef0A:
15.33
6f5uB-2ef0A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2ef0 ORNITHINE
CARBAMOYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 VAL A 157
ALA A 216
LEU A 179
LEU A 152
LEU A 170
 None
 0.94A 6f6nA-2ef0A:
0.8
6f6nB-2ef0A:
undetectable		 6f6nA-2ef0A:
15.33
6f6nB-2ef0A:
14.58