SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ef4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 9 LEU A 259
VAL A 279
GLY A 280
ALA A 275
LEU A  27
 None
 1.19A 1e7bA-2ef4A:
undetectable		 1e7bA-2ef4A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 2ef4 ARGINASE
(Thermus
thermophilus) 		4 / 8 ASP A  21
VAL A   9
GLY A  95
GLY A  94
 None
 0.91A 1ekjE-2ef4A:
undetectable
1ekjF-2ef4A:
undetectable		 1ekjE-2ef4A:
21.90
1ekjF-2ef4A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 10 LEU A 278
LEU A 281
ALA A 282
LEU A 259
LEU A  93
 None
 1.14A 1gwrA-2ef4A:
undetectable		 1gwrA-2ef4A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2ef4 ARGINASE
(Thermus
thermophilus) 		3 / 3 THR A 274
LEU A 278
LEU A 285
 None
 0.54A 1mz9C-2ef4A:
undetectable		 1mz9C-2ef4A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 11 LEU A 268
PRO A 233
ARG A  18
HIS A 136
VAL A  20
 None
 1.13A 1tmxA-2ef4A:
undetectable		 1tmxA-2ef4A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 12 LEU A  75
VAL A 142
GLU A 153
LEU A 151
ARG A  71
 None
 1.23A 2bxfB-2ef4A:
undetectable		 2bxfB-2ef4A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ef4 ARGINASE
(Thermus
thermophilus) 		3 / 3 LEU A 140
PRO A 139
LEU A 143
 None
 0.63A 2po5B-2ef4A:
2.5		 2po5B-2ef4A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ef4 ARGINASE
(Thermus
thermophilus) 		3 / 3 LEU A 140
PRO A 139
LEU A 143
 None
 0.58A 2po7B-2ef4A:
3.0		 2po7B-2ef4A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 12 LEU A  77
GLY A 106
VAL A  51
ALA A 107
SER A  98
 None
 1.23A 2vmyB-2ef4A:
2.5		 2vmyB-2ef4A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1437_1
(ORF12)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 11 SER A 103
ALA A 107
GLY A 106
ALA A 105
ARG A 111
 None
 1.32A 2xh9A-2ef4A:
undetectable		 2xh9A-2ef4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1437_1
(ORF12)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 10 SER A 103
ALA A 107
GLY A 106
ALA A 105
ARG A 111
 None
 1.28A 2xh9B-2ef4A:
undetectable		 2xh9B-2ef4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 2ef4 ARGINASE
(Thermus
thermophilus) 		4 / 8 ARG A 112
SER A 100
VAL A 184
VAL A 158
 None
 1.23A 2y05A-2ef4A:
4.1
2y05B-2ef4A:
4.1		 2y05A-2ef4A:
24.44
2y05B-2ef4A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 2ef4 ARGINASE
(Thermus
thermophilus) 		4 / 6 LEU A 261
GLY A  94
LEU A 259
SER A 258
 None
 0.74A 3aiaA-2ef4A:
undetectable		 3aiaA-2ef4A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 12 ALA A 243
LEU A 278
LEU A 281
LEU A 285
HIS A  97
 None
 0.97A 3erdA-2ef4A:
undetectable		 3erdA-2ef4A:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_A_DMOA551_1
(ARGINASE-1)		 2ef4 ARGINASE
(Thermus
thermophilus) 		8 / 9 HIS A 121
ASP A 123
ASN A 125
SER A 132
GLY A 137
ASP A 172
GLU A 175
THR A 232
 None
 0.54A 3gn0A-2ef4A:
41.5		 3gn0A-2ef4A:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_A_DMOA551_1
(ARGINASE-1)		 2ef4 ARGINASE
(Thermus
thermophilus) 		8 / 9 HIS A 121
ASP A 123
ASN A 125
SER A 132
HIS A 136
GLY A 137
ASP A 172
GLU A 175
 None
 0.69A 3gn0A-2ef4A:
41.5		 3gn0A-2ef4A:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_A_DMOA551_1
(ARGINASE-1)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 9 HIS A 121
ASP A 123
SER A 130
HIS A 136
GLY A 137
 None
 1.19A 3gn0A-2ef4A:
41.5		 3gn0A-2ef4A:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_B_DMOB552_1
(ARGINASE-1)		 2ef4 ARGINASE
(Thermus
thermophilus) 		8 / 9 HIS A 121
ASP A 123
ASN A 125
SER A 132
GLY A 137
ASP A 172
GLU A 175
THR A 232
 None
 0.50A 3gn0B-2ef4A:
41.7		 3gn0B-2ef4A:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_B_DMOB552_1
(ARGINASE-1)		 2ef4 ARGINASE
(Thermus
thermophilus) 		8 / 9 HIS A 121
ASP A 123
ASN A 125
SER A 132
HIS A 136
GLY A 137
ASP A 172
GLU A 175
 None
 0.62A 3gn0B-2ef4A:
41.7		 3gn0B-2ef4A:
39.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN0_B_DMOB552_1
(ARGINASE-1)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 9 HIS A 121
ASP A 123
SER A 130
HIS A 136
GLY A 137
 None
 1.17A 3gn0B-2ef4A:
41.7		 3gn0B-2ef4A:
39.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ef4 ARGINASE
(Thermus
thermophilus) 		3 / 3 LEU A 140
PRO A 139
LEU A 143
 None
 0.54A 3hcrA-2ef4A:
2.9		 3hcrA-2ef4A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ef4 ARGINASE
(Thermus
thermophilus) 		4 / 7 VAL A 118
VAL A 215
LEU A 259
SER A 258
 None
 0.75A 3hs6B-2ef4A:
undetectable		 3hs6B-2ef4A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2ef4 ARGINASE
(Thermus
thermophilus) 		4 / 7 GLU A 276
VAL A 279
VAL A 264
ALA A  26
 None
 0.97A 3kp6B-2ef4A:
undetectable		 3kp6B-2ef4A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2ef4 ARGINASE
(Thermus
thermophilus) 		3 / 3 ARG A 177
GLU A 175
THR A 126
 None
 0.88A 3v4tA-2ef4A:
undetectable		 3v4tA-2ef4A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 2ef4 ARGINASE
(Thermus
thermophilus) 		4 / 7 GLY A 167
ASP A 119
VAL A 221
HIS A  97
 None
 0.93A 4c5nA-2ef4A:
4.6		 4c5nA-2ef4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 12 PRO A 139
ALA A  74
ASP A  21
MET A  11
GLY A  95
 None
 0.85A 4j7xA-2ef4A:
3.0		 4j7xA-2ef4A:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2ef4 ARGINASE
(Thermus
thermophilus) 		4 / 6 THR A 126
GLU A 128
THR A 129
LEU A 146
 None
 0.82A 4pgfA-2ef4A:
2.7		 4pgfA-2ef4A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 12 LEU A 278
LEU A 281
ALA A 282
LEU A 259
LEU A  93
 None
 1.11A 4pxmA-2ef4A:
undetectable		 4pxmA-2ef4A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 2ef4 ARGINASE
(Thermus
thermophilus) 		3 / 3 ASP A 119
ASP A 123
ASN A 134
 None
 0.76A 4q5mA-2ef4A:
undetectable		 4q5mA-2ef4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 11 HIS A  97
THR A 232
GLY A 229
ALA A 219
THR A 274
 None
 1.46A 4qvlV-2ef4A:
undetectable
4qvlb-2ef4A:
undetectable		 4qvlV-2ef4A:
22.92
4qvlb-2ef4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 11 HIS A  97
THR A 232
GLY A 229
ALA A 219
THR A 274
 None
 1.46A 4qvlH-2ef4A:
undetectable
4qvlN-2ef4A:
undetectable		 4qvlH-2ef4A:
22.92
4qvlN-2ef4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 11 HIS A  97
THR A 232
GLY A 229
ALA A 219
THR A 274
 None
 1.47A 4qvmV-2ef4A:
undetectable
4qvmb-2ef4A:
undetectable		 4qvmV-2ef4A:
22.92
4qvmb-2ef4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 11 HIS A  97
THR A 232
GLY A 229
ALA A 219
THR A 274
 None
 1.47A 4qvmH-2ef4A:
undetectable
4qvmN-2ef4A:
undetectable		 4qvmH-2ef4A:
22.92
4qvmN-2ef4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 11 HIS A  97
THR A 232
GLY A 229
ALA A 219
THR A 274
 None
 1.48A 4qvpV-2ef4A:
undetectable
4qvpb-2ef4A:
undetectable		 4qvpV-2ef4A:
22.92
4qvpb-2ef4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 11 HIS A  97
THR A 232
GLY A 229
ALA A 219
THR A 274
 None
 1.47A 4qvpH-2ef4A:
undetectable
4qvpN-2ef4A:
undetectable		 4qvpH-2ef4A:
22.92
4qvpN-2ef4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 11 HIS A  97
THR A 232
GLY A 229
ALA A 219
THR A 274
 None
 1.47A 4qvwV-2ef4A:
undetectable
4qvwb-2ef4A:
undetectable		 4qvwV-2ef4A:
22.92
4qvwb-2ef4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 9 PRO A  90
GLY A 102
ILE A  91
SER A 258
LEU A 259
 None
 1.22A 4x3mB-2ef4A:
undetectable		 4x3mB-2ef4A:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 12 LEU A 151
GLY A 102
ALA A  74
ILE A  70
ASP A 119
 None
 1.21A 4xe5A-2ef4A:
undetectable		 4xe5A-2ef4A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 12 GLY A   8
GLY A  94
GLY A  95
ALA A   5
LEU A  81
 None
 0.99A 5c0oF-2ef4A:
undetectable		 5c0oF-2ef4A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 2ef4 ARGINASE
(Thermus
thermophilus) 		4 / 6 ALA A 120
SER A 170
ASP A 223
PRO A 224
 None
 0.83A 5c6pA-2ef4A:
undetectable		 5c6pA-2ef4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 11 HIS A  97
THR A 232
GLY A 229
ALA A 219
THR A 274
 None
 1.46A 5cz7H-2ef4A:
undetectable
5cz7N-2ef4A:
undetectable		 5cz7H-2ef4A:
22.92
5cz7N-2ef4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 11 HIS A  97
THR A 232
GLY A 229
ALA A 219
THR A 274
 None
 1.48A 5d0xH-2ef4A:
undetectable
5d0xN-2ef4A:
undetectable		 5d0xH-2ef4A:
22.92
5d0xN-2ef4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_1
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2ef4 ARGINASE
(Thermus
thermophilus) 		4 / 4 ASP A  12
HIS A 136
SER A  98
GLU A 263
 None
 1.33A 5hfjC-2ef4A:
4.7		 5hfjC-2ef4A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 12 LEU A 208
VAL A 115
LEU A 165
VAL A 186
GLY A 183
 None
 1.47A 5i8fA-2ef4A:
undetectable		 5i8fA-2ef4A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 12 VAL A 158
ASP A 159
THR A 188
GLY A 183
LEU A 179
 None
 1.24A 5m54E-2ef4A:
3.6		 5m54E-2ef4A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2ef4 ARGINASE
(Thermus
thermophilus) 		4 / 5 VAL A  20
HIS A 121
LEU A 268
ASP A 218
 None
 1.44A 5vcvA-2ef4A:
undetectable		 5vcvA-2ef4A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 12 MET A 247
ALA A 251
GLY A 254
SER A 253
LEU A 205
 None
 1.44A 5vlmF-2ef4A:
undetectable		 5vlmF-2ef4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 12 LEU A 261
VAL A 279
GLY A 280
SER A 284
VAL A   4
 None
 1.43A 6a94A-2ef4A:
undetectable		 6a94A-2ef4A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 12 TRP A 117
VAL A   9
GLY A   8
PHE A  89
VAL A 104
 None
 1.31A 6a94A-2ef4A:
undetectable		 6a94A-2ef4A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2ef4 ARGINASE
(Thermus
thermophilus) 		5 / 12 VAL A 158
ASP A 159
THR A 188
GLY A 183
LEU A 179
 None
 0.99A 6b0lB-2ef4A:
3.1		 6b0lB-2ef4A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 2ef4 ARGINASE
(Thermus
thermophilus) 		3 / 3 ARG A 177
GLY A 174
GLU A 175
 None
 0.61A 6fgdA-2ef4A:
5.2		 6fgdA-2ef4A:
21.14