SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2efe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)
2efe SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana)
5 / 11 PHE B  90
TRP B 104
ILE B 163
ALA B 119
LEU B 120
None
1.44A 1jb0B-2efeB:
undetectable
1jb0B-2efeB:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9
SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana;
Arabidopsis
thaliana)
4 / 6 ASN A 168
ASN A 167
ILE B  43
GLY B  44
None
1.06A 1oniA-2efeA:
undetectable
1oniB-2efeA:
undetectable
1oniA-2efeA:
20.66
1oniB-2efeA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9
SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana;
Arabidopsis
thaliana)
4 / 6 ASN A 168
ASN A 167
ILE B  43
GLY B  44
None
1.10A 1oniD-2efeA:
undetectable
1oniF-2efeA:
undetectable
1oniD-2efeA:
20.66
1oniF-2efeA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9

(Arabidopsis
thaliana)
4 / 8 SER A  97
ASN A  98
TYR A 213
ASP A  42
None
1.04A 2v57A-2efeA:
0.9
2v57A-2efeA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9

(Arabidopsis
thaliana)
4 / 8 SER A  97
ASN A  98
TYR A 213
ASP A  42
None
1.03A 2v57C-2efeA:
undetectable
2v57C-2efeA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9
SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana)
5 / 8 VAL B  27
GLY A 183
GLU A 186
PHE A 130
ALA A 181
None
None
GNH  B1200 ( 4.8A)
None
None
1.20A 3aruA-2efeB:
2.1
3aruA-2efeB:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9
SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana)
4 / 8 SER B  49
PHE B  47
ALA A 224
ALA A 223
None
0.90A 3ax9B-2efeB:
undetectable
3ax9B-2efeB:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)
2efe SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana)
5 / 9 VAL B  89
GLY B 122
GLN B  69
ASN B 123
GLY B  22
None
None
None
GNH  B1200 (-3.4A)
GNH  B1200 (-3.2A)
1.34A 3kmoA-2efeB:
undetectable
3kmoA-2efeB:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)
2efe SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana)
3 / 3 LEU B 108
TRP B 104
GLY B  17
None
0.79A 3l35A-2efeB:
undetectable
3l35H-2efeB:
undetectable
3l35A-2efeB:
14.37
3l35H-2efeB:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)
2efe SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana)
3 / 3 LEU B 108
TRP B 104
GLY B  17
None
0.81A 3l35B-2efeB:
undetectable
3l35K-2efeB:
undetectable
3l35B-2efeB:
14.37
3l35K-2efeB:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9
SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana)
5 / 12 VAL B  89
VAL B  27
LEU B  28
GLY A 183
LEU B  15
None
1.04A 3n8wA-2efeB:
undetectable
3n8wA-2efeB:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9
SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana)
4 / 8 SER B  49
PHE B  47
ALA A 224
ALA A 223
None
0.91A 3ns1L-2efeB:
undetectable
3ns1L-2efeB:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9

(Arabidopsis
thaliana)
5 / 10 ILE A 240
PHE A 236
ILE A 237
ILE A 119
SER A 120
None
0.93A 3o1cA-2efeA:
undetectable
3o1cA-2efeA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9

(Arabidopsis
thaliana)
5 / 10 ILE A 240
PHE A 236
ILE A 237
ILE A 119
SER A 120
None
1.06A 3o1xA-2efeA:
undetectable
3o1xA-2efeA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9

(Arabidopsis
thaliana)
4 / 6 ILE A 159
ASN A 206
PRO A 200
LEU A 143
None
1.30A 3oi8A-2efeA:
undetectable
3oi8A-2efeA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)
2efe SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana)
5 / 11 PHE B  90
TRP B 104
ILE B 163
ALA B 119
LEU B 120
None
1.44A 3pcqB-2efeB:
undetectable
3pcqB-2efeB:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9

(Arabidopsis
thaliana)
5 / 10 ILE A 240
PHE A 236
ILE A 237
ILE A 119
SER A 120
None
1.09A 3qgzA-2efeA:
undetectable
3qgzA-2efeA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9

(Arabidopsis
thaliana)
3 / 3 TYR A  85
LEU A 156
LYS A 155
None
0.70A 3sueD-2efeA:
undetectable
3sueD-2efeA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)
2efe SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana)
5 / 10 PHE B  90
VAL B 105
PHE B 149
ALA B 142
PHE B  98
None
1.28A 3t3qB-2efeB:
undetectable
3t3qB-2efeB:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)
2efe SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana)
5 / 10 PHE B  90
VAL B 105
PHE B 149
ALA B 142
PHE B  98
None
1.29A 3t3qD-2efeB:
undetectable
3t3qD-2efeB:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9

(Arabidopsis
thaliana)
3 / 3 PHE A  61
ASP A  76
ARG A 215
None
0.83A 4eahF-2efeA:
undetectable
4eahF-2efeA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9

(Arabidopsis
thaliana)
3 / 3 PHE A  61
ASP A  76
ARG A 215
None
0.83A 4eahG-2efeA:
undetectable
4eahG-2efeA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)
2efe SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana)
4 / 7 ALA B 138
ASP B 137
VAL B  92
THR B 152
None
0.97A 4eyrA-2efeB:
undetectable
4eyrA-2efeB:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9

(Arabidopsis
thaliana)
4 / 8 VAL A 194
ILE A 166
SER A 135
ALA A 173
None
0.98A 4eyzA-2efeA:
undetectable
4eyzA-2efeA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9

(Arabidopsis
thaliana)
4 / 8 VAL A 194
ILE A 166
SER A 135
ALA A 173
None
1.00A 4eyzB-2efeA:
undetectable
4eyzB-2efeA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)
2efe SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana)
3 / 3 ARG B 100
LYS B 102
LYS B 103
None
1.31A 4k50E-2efeB:
undetectable
4k50E-2efeB:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_B_CP6B201_1
(DIHYDROFOLATE
REDUCTASE)
2efe SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana)
6 / 12 ILE B 167
ALA B  86
ILE B  88
PHE B 148
THR B 152
ILE B 163
None
1.43A 4km0B-2efeB:
undetectable
4km0B-2efeB:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9

(Arabidopsis
thaliana)
5 / 12 LEU A 188
PHE A 187
LEU A 160
ILE A 210
LEU A 219
None
1.28A 5ienA-2efeA:
undetectable
5ienA-2efeA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9
SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana;
Arabidopsis
thaliana)
4 / 5 TYR B  72
SER A 232
ALA A 233
THR A 195
None
1.23A 5n0wB-2efeB:
undetectable
5n0wB-2efeB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9
SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana;
Arabidopsis
thaliana)
4 / 5 TYR B  72
SER A 232
ALA A 233
THR A 195
None
1.25A 5n4iA-2efeB:
2.2
5n4iA-2efeB:
17.96