SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2efl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_A_LYAA317_1
(THYMIDYLATE SYNTHASE)		 2efl FORMIN-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 PHE A  11
ILE A 216
LEU A   7
GLY A   4
PHE A 213
 None
 1.30A 1ju6A-2eflA:
undetectable		 1ju6A-2eflA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2efl FORMIN-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 7 TYR A 272
TYR A  67
CYH A  70
GLU A  64
 None
 1.34A 2xytH-2eflA:
undetectable		 2xytH-2eflA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 2efl FORMIN-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 HIS A 206
GLU A 203
HIS A 199
 None
 0.89A 3ba0A-2eflA:
undetectable		 3ba0A-2eflA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_1
(PROLINE--TRNA LIGASE)		 2efl FORMIN-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 GLU A 200
THR A 207
HIS A 208
 None
 0.83A 4ydqB-2eflA:
undetectable		 4ydqB-2eflA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 2efl FORMIN-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 GLN A  19
HIS A  17
ILE A  22
ILE A  24
 None
 1.16A 5dnuA-2eflA:
undetectable		 5dnuA-2eflA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 2efl FORMIN-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 GLN A  19
HIS A  17
ILE A  22
ILE A  24
 None
 1.17A 5dnvA-2eflA:
undetectable		 5dnvA-2eflA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 2efl FORMIN-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 GLU A 203
GLY A 120
ASP A 119
ALA A 123
PRO A 210
 None
 1.18A 5yk2A-2eflA:
0.7		 5yk2A-2eflA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 2efl FORMIN-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 GLN A 214
THR A  18
HIS A  17
GLY A   4
 None
 1.21A 6gbnC-2eflA:
undetectable		 6gbnC-2eflA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 2efl FORMIN-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 11 PHE A  11
ILE A 216
LEU A   7
GLY A   4
PHE A 213
 None
 1.33A 6r2eG-2eflA:
undetectable		 6r2eG-2eflA:
22.13