SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eg3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE
(Thermus
thermophilus) 		4 / 6 LEU A 204
LEU A 207
LEU A 179
LEU A 133
 None
 0.91A 2ab2A-2eg3A:
undetectable		 2ab2A-2eg3A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE
(Thermus
thermophilus) 		4 / 7 GLU A 229
PRO A 140
LYS A 146
GLY A 156
 SO4  A 503 ( 2.7A)
None
None
None
 1.15A 2hs1B-2eg3A:
undetectable		 2hs1B-2eg3A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A  66
LEU A  60
GLY A  25
HIS A  22
LEU A  23
 None
 1.10A 2j7xA-2eg3A:
undetectable		 2j7xA-2eg3A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A  51
LEU A  54
PHE A  55
LEU A  58
VAL A  89
 None
 1.00A 2pnjA-2eg3A:
2.2		 2pnjA-2eg3A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ALA A 164
LEU A 181
ALA A 200
CYH A 191
VAL A 187
 None
 1.06A 3rukA-2eg3A:
undetectable		 3rukA-2eg3A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A  66
LEU A  60
GLY A  25
HIS A  22
LEU A  23
 None
 1.13A 4j26A-2eg3A:
undetectable		 4j26A-2eg3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5J_B_H4BB502_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE
(Thermus
thermophilus) 		4 / 7 PHE A  55
GLU A  88
SER A  62
VAL A  89
 None
 1.42A 4k5jA-2eg3A:
undetectable
4k5jB-2eg3A:
undetectable		 4k5jA-2eg3A:
17.82
4k5jB-2eg3A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ASP A 136
PRO A 227
ALA A 129
GLY A 156
SER A 161
 None
 1.04A 4mmdB-2eg3A:
undetectable		 4mmdB-2eg3A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_C_CHDC102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE
(Thermus
thermophilus) 		4 / 7 GLU A  43
LEU A  47
LEU A 117
LEU A  84
 None
 0.58A 4wg0B-2eg3A:
undetectable
4wg0C-2eg3A:
undetectable		 4wg0B-2eg3A:
4.35
4wg0C-2eg3A:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE
(Thermus
thermophilus) 		4 / 7 LEU A 117
LEU A  84
GLU A  43
LEU A  47
 None
 0.60A 4wg0L-2eg3A:
undetectable
4wg0M-2eg3A:
undetectable		 4wg0L-2eg3A:
4.35
4wg0M-2eg3A:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE
(Thermus
thermophilus) 		5 / 10 LEU A  60
LEU A  82
SER A  32
LEU A  31
LEU A  66
 None
 1.07A 4yiaA-2eg3A:
undetectable		 4yiaA-2eg3A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE
(Thermus
thermophilus) 		5 / 12 THR A 124
LEU A  84
GLY A 194
SER A 197
ALA A 198
 None
 1.05A 4ypmA-2eg3A:
undetectable		 4ypmA-2eg3A:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE
(Thermus
thermophilus) 		4 / 5 THR A  57
GLY A  59
GLU A 105
HIS A  28
 None
 1.22A 5c0oH-2eg3A:
undetectable		 5c0oH-2eg3A:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE
(Thermus
thermophilus) 		5 / 11 VAL A  10
VAL A  64
VAL A   8
PHE A  55
LEU A  82
 None
 0.91A 5e4dB-2eg3A:
undetectable		 5e4dB-2eg3A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2eg3 PROBABLE THIOSULFATE
SULFURTRANSFERASE
(Thermus
thermophilus) 		4 / 6 PHE A 202
ALA A 198
SER A  73
THR A  12
 None
None
SO4  A 505 (-4.0A)
None
 0.98A 6f88A-2eg3A:
undetectable		 6f88A-2eg3A:
17.12