SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eg5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		3 / 3 PHE A 208
LEU A 224
LEU A 363
 None
 0.65A 1mx1E-2eg5A:
undetectable		 1mx1E-2eg5A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		4 / 4 ALA A 310
VAL A 313
ALA A 314
HIS A 339
 None
 1.20A 1q23A-2eg5A:
undetectable		 1q23A-2eg5A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		4 / 7 ILE A 287
LEU A 363
THR A 292
LEU A 359
 None
 0.92A 1v55A-2eg5A:
undetectable
1v55J-2eg5A:
undetectable		 1v55A-2eg5A:
22.14
1v55J-2eg5A:
9.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		5 / 12 TYR A  18
TYR A 158
TRP A 162
ILE A 227
TYR A 321
 None
XTS  A 502 ( 4.9A)
XTS  A 502 (-4.5A)
None
XTS  A 502 (-4.6A)
 0.44A 2efjA-2eg5A:
47.8		 2efjA-2eg5A:
81.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		5 / 12 ILE A 246
ALA A 245
ALA A 238
LEU A 265
PHE A 329
 None
None
XTS  A 502 ( 4.3A)
None
None
 1.13A 2h77A-2eg5A:
undetectable		 2h77A-2eg5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		5 / 12 ILE A 246
ALA A 245
ALA A 238
LEU A 265
PHE A 329
 None
None
XTS  A 502 ( 4.3A)
None
None
 1.08A 2h79A-2eg5A:
undetectable		 2h79A-2eg5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		4 / 4 PRO A 104
ASP A 101
ASP A  59
ASP A 106
 None
SAH  A 501 (-2.9A)
SAH  A 501 ( 4.6A)
None
 1.40A 2nyuA-2eg5A:
8.7		 2nyuA-2eg5A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		4 / 8 ILE A 337
LEU A 265
ILE A 246
PHE A 329
 None
 0.79A 2w9sE-2eg5A:
undetectable		 2w9sE-2eg5A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		3 / 3 SER A 316
HIS A 339
ASP A 248
 XTS  A 502 (-2.5A)
None
None
 0.77A 2wa2B-2eg5A:
6.3		 2wa2B-2eg5A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		4 / 8 ILE A 287
LEU A 363
THR A 292
LEU A 359
 None
 0.88A 3ablN-2eg5A:
undetectable
3ablW-2eg5A:
undetectable		 3ablN-2eg5A:
22.14
3ablW-2eg5A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		4 / 8 ILE A 287
LEU A 363
THR A 292
LEU A 359
 None
 0.92A 3abmN-2eg5A:
undetectable
3abmW-2eg5A:
undetectable		 3abmN-2eg5A:
22.14
3abmW-2eg5A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		4 / 7 ILE A 287
LEU A 363
THR A 292
LEU A 359
 None
 0.96A 3ag3A-2eg5A:
undetectable
3ag3J-2eg5A:
undetectable		 3ag3A-2eg5A:
22.14
3ag3J-2eg5A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		4 / 8 ILE A 287
LEU A 363
THR A 292
LEU A 359
 None
 0.92A 3asoN-2eg5A:
undetectable
3asoW-2eg5A:
undetectable		 3asoN-2eg5A:
22.14
3asoW-2eg5A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		6 / 12 LEU A 325
ALA A 245
ASP A 248
PRO A 335
ILE A 334
ILE A 337
 None
 1.45A 3s54B-2eg5A:
undetectable		 3s54B-2eg5A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		5 / 12 ILE A 334
ILE A 333
LEU A 325
LEU A 242
ILE A 183
 None
 1.06A 3uvvA-2eg5A:
undetectable		 3uvvA-2eg5A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		3 / 3 ARG A  73
GLU A 124
ASN A 125
 None
 0.85A 4imaD-2eg5A:
2.4		 4imaD-2eg5A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		3 / 3 ARG A  73
GLU A 124
ASN A 125
 None
 0.88A 4ip7D-2eg5A:
2.8		 4ip7D-2eg5A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		5 / 12 ILE A 246
ALA A 245
ALA A 238
LEU A 265
PHE A 329
 None
None
XTS  A 502 ( 4.3A)
None
None
 1.08A 4lnwA-2eg5A:
undetectable		 4lnwA-2eg5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		5 / 12 ILE A 246
ALA A 245
ALA A 238
LEU A 265
PHE A 329
 None
None
XTS  A 502 ( 4.3A)
None
None
 1.09A 4lnxA-2eg5A:
undetectable		 4lnxA-2eg5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		5 / 12 ASP A  59
GLY A  61
THR A  71
ASP A 101
LEU A 102
 SAH  A 501 ( 4.6A)
SAH  A 501 (-3.8A)
None
SAH  A 501 (-2.9A)
SAH  A 501 (-4.4A)
 0.97A 4pghB-2eg5A:
12.9		 4pghB-2eg5A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		5 / 11 ASP A 240
ALA A 314
VAL A 317
TYR A 321
GLY A 354
 None
None
XTS  A 502 ( 4.9A)
XTS  A 502 (-4.6A)
None
 1.11A 4xnxA-2eg5A:
undetectable		 4xnxA-2eg5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		4 / 7 ILE A 287
LEU A 363
THR A 292
LEU A 359
 None
 0.91A 5b1aA-2eg5A:
undetectable
5b1aJ-2eg5A:
undetectable		 5b1aA-2eg5A:
22.14
5b1aJ-2eg5A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		4 / 7 ILE A 287
LEU A 363
THR A 292
LEU A 359
 None
 0.93A 5b3sA-2eg5A:
undetectable
5b3sJ-2eg5A:
undetectable		 5b3sA-2eg5A:
22.14
5b3sJ-2eg5A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		3 / 3 VAL A  72
GLN A  96
CYH A 132
 None
 0.55A 5icxC-2eg5A:
undetectable
5icxF-2eg5A:
undetectable		 5icxC-2eg5A:
19.79
5icxF-2eg5A:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		4 / 7 LEU A 249
ALA A 245
ILE A 183
LEU A 260
 None
 0.89A 5te8C-2eg5A:
undetectable		 5te8C-2eg5A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		4 / 7 ILE A 287
LEU A 363
THR A 292
LEU A 359
 None
 0.90A 5xdqN-2eg5A:
undetectable
5xdqW-2eg5A:
undetectable		 5xdqN-2eg5A:
22.14
5xdqW-2eg5A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		4 / 7 ILE A 287
LEU A 363
THR A 292
LEU A 359
 None
 0.91A 5xdxA-2eg5A:
undetectable
5xdxJ-2eg5A:
undetectable		 5xdxA-2eg5A:
22.14
5xdxJ-2eg5A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		4 / 8 ILE A 287
LEU A 363
THR A 292
LEU A 359
 None
 0.92A 5xdxN-2eg5A:
0.0
5xdxW-2eg5A:
undetectable		 5xdxN-2eg5A:
22.14
5xdxW-2eg5A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		5 / 12 LEU A  44
ILE A  55
TYR A 118
LEU A 121
LEU A  99
 None
 0.98A 5ycnA-2eg5A:
undetectable		 5ycnA-2eg5A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		4 / 7 ILE A 287
LEU A 363
THR A 292
LEU A 359
 None
 0.94A 5zcpA-2eg5A:
undetectable
5zcpJ-2eg5A:
undetectable		 5zcpA-2eg5A:
22.14
5zcpJ-2eg5A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		4 / 7 ILE A 287
LEU A 363
THR A 292
LEU A 359
 None
 0.93A 5zcqA-2eg5A:
undetectable
5zcqJ-2eg5A:
undetectable		 5zcqA-2eg5A:
22.14
5zcqJ-2eg5A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		5 / 10 ILE A 360
VAL A 279
LEU A 359
LEU A 223
LEU A 363
 None
 0.99A 6f6nA-2eg5A:
0.3
6f6nB-2eg5A:
undetectable		 6f6nA-2eg5A:
12.23
6f6nB-2eg5A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		4 / 7 ILE A 287
LEU A 363
THR A 292
LEU A 359
 None
 0.92A 6nmfA-2eg5A:
0.0
6nmfJ-2eg5A:
undetectable		 6nmfA-2eg5A:
22.14
6nmfJ-2eg5A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2eg5 XANTHOSINE
METHYLTRANSFERASE
(Coffea
canephora) 		4 / 5 ILE A 287
LEU A 363
THR A 292
LEU A 359
 None
 0.92A 6nmpN-2eg5A:
undetectable
6nmpW-2eg5A:
undetectable		 6nmpN-2eg5A:
22.14
6nmpW-2eg5A:
9.56