SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ego'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2ego GENERAL RECEPTOR FOR
PHOSPHOINOSITIDES
1-ASSOCIATED
SCAFFOLD PROTEIN
(Rattus
norvegicus) 		5 / 8 ALA A 146
LEU A 103
LEU A 181
VAL A 157
ILE A 170
 None
 1.40A 2uxpA-2egoA:
undetectable		 2uxpA-2egoA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 2ego GENERAL RECEPTOR FOR
PHOSPHOINOSITIDES
1-ASSOCIATED
SCAFFOLD PROTEIN
(Rattus
norvegicus) 		5 / 10 THR A 185
LEU A 101
GLY A 147
THR A 149
VAL A 134
 None
 1.31A 3lxiA-2egoA:
undetectable		 3lxiA-2egoA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 2ego GENERAL RECEPTOR FOR
PHOSPHOINOSITIDES
1-ASSOCIATED
SCAFFOLD PROTEIN
(Rattus
norvegicus) 		5 / 9 THR A 185
LEU A 101
GLY A 147
THR A 149
VAL A 134
 None
 1.33A 4c9kA-2egoA:
undetectable		 4c9kA-2egoA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 2ego GENERAL RECEPTOR FOR
PHOSPHOINOSITIDES
1-ASSOCIATED
SCAFFOLD PROTEIN
(Rattus
norvegicus) 		5 / 9 THR A 185
LEU A 101
GLY A 147
THR A 149
VAL A 134
 None
 1.33A 4c9kB-2egoA:
undetectable		 4c9kB-2egoA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 2ego GENERAL RECEPTOR FOR
PHOSPHOINOSITIDES
1-ASSOCIATED
SCAFFOLD PROTEIN
(Rattus
norvegicus) 		6 / 12 THR A 185
LEU A 101
GLY A 147
THR A 149
VAL A 134
ILE A 154
 None
 1.27A 4c9lA-2egoA:
undetectable		 4c9lA-2egoA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 2ego GENERAL RECEPTOR FOR
PHOSPHOINOSITIDES
1-ASSOCIATED
SCAFFOLD PROTEIN
(Rattus
norvegicus) 		6 / 12 THR A 185
LEU A 101
GLY A 147
THR A 149
VAL A 134
ILE A 154
 None
 1.27A 4c9lB-2egoA:
undetectable		 4c9lB-2egoA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 2ego GENERAL RECEPTOR FOR
PHOSPHOINOSITIDES
1-ASSOCIATED
SCAFFOLD PROTEIN
(Rattus
norvegicus) 		5 / 8 THR A 185
LEU A 101
GLY A 147
THR A 149
VAL A 134
 None
 1.35A 4c9nA-2egoA:
undetectable		 4c9nA-2egoA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 2ego GENERAL RECEPTOR FOR
PHOSPHOINOSITIDES
1-ASSOCIATED
SCAFFOLD PROTEIN
(Rattus
norvegicus) 		6 / 12 THR A 185
LEU A 101
GLY A 147
THR A 149
VAL A 134
ILE A 154
 None
 1.32A 4c9oA-2egoA:
undetectable		 4c9oA-2egoA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 2ego GENERAL RECEPTOR FOR
PHOSPHOINOSITIDES
1-ASSOCIATED
SCAFFOLD PROTEIN
(Rattus
norvegicus) 		6 / 12 THR A 185
LEU A 101
GLY A 147
THR A 149
VAL A 134
ILE A 154
 None
 1.32A 4c9oB-2egoA:
undetectable		 4c9oB-2egoA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2ego GENERAL RECEPTOR FOR
PHOSPHOINOSITIDES
1-ASSOCIATED
SCAFFOLD PROTEIN
(Rattus
norvegicus) 		5 / 12 VAL A 134
SER A 141
LEU A 181
PHE A 113
GLY A 112
 None
 1.48A 4pevC-2egoA:
undetectable		 4pevC-2egoA:
14.08