SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2egu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 2egu CYSTEINE SYNTHASE
(Geobacillus
kaustophilus) 		4 / 7 TYR A 304
GLY A 263
ILE A 271
GLY A 260
 None
 0.80A 11gsB-2eguA:
undetectable		 11gsB-2eguA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 2egu CYSTEINE SYNTHASE
(Geobacillus
kaustophilus) 		4 / 6 ILE A 241
LYS A 276
ALA A 278
VAL A 174
 None
 0.95A 1hk1A-2eguA:
undetectable		 1hk1A-2eguA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2egu CYSTEINE SYNTHASE
(Geobacillus
kaustophilus) 		3 / 3 THR A  76
LEU A  80
VAL A  83
 None
 0.63A 1mz9E-2eguA:
undetectable		 1mz9E-2eguA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 2egu CYSTEINE SYNTHASE
(Geobacillus
kaustophilus) 		5 / 12 ILE A 291
THR A 158
ILE A 162
LEU A 288
ILE A 290
 None
 1.04A 1rd7B-2eguA:
undetectable		 1rd7B-2eguA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2egu CYSTEINE SYNTHASE
(Geobacillus
kaustophilus) 		5 / 8 ALA A 251
GLY A 264
GLY A 263
ILE A 261
ALA A 274
 None
 1.21A 1sguA-2eguA:
undetectable		 1sguA-2eguA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 2egu CYSTEINE SYNTHASE
(Geobacillus
kaustophilus) 		5 / 12 ALA A 289
ILE A 271
SER A 267
ALA A 274
ILE A 162
 None
 1.09A 1ve3A-2eguA:
2.8		 1ve3A-2eguA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 2egu CYSTEINE SYNTHASE
(Geobacillus
kaustophilus) 		4 / 5 ALA A 289
TYR A  32
ALA A 274
GLN A 169
 None
 1.04A 1xl6A-2eguA:
undetectable
1xl6B-2eguA:
undetectable		 1xl6A-2eguA:
23.05
1xl6B-2eguA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DM6_A_IMNA1401_1
(NADP-DEPENDENT
LEUKOTRIENE B4
12-HYDROXYDEHYDROGEN
ASE)		 2egu CYSTEINE SYNTHASE
(Geobacillus
kaustophilus) 		5 / 10 TYR A  32
ILE A 261
PRO A 292
GLU A  36
ILE A 291
 None
 1.20A 2dm6A-2eguA:
3.6
2dm6B-2eguA:
3.6		 2dm6A-2eguA:
24.65
2dm6B-2eguA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 2egu CYSTEINE SYNTHASE
(Geobacillus
kaustophilus) 		5 / 12 GLY A 264
GLY A 263
ALA A 256
ASP A 206
PRO A 302
 None
 1.11A 2dpmA-2eguA:
undetectable		 2dpmA-2eguA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 2egu CYSTEINE SYNTHASE
(Geobacillus
kaustophilus) 		4 / 8 GLY A 268
ALA A 270
THR A 179
ILE A 291
 None
 0.82A 2dtjA-2eguA:
undetectable
2dtjB-2eguA:
undetectable		 2dtjA-2eguA:
21.68
2dtjB-2eguA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 2egu CYSTEINE SYNTHASE
(Geobacillus
kaustophilus) 		3 / 3 ARG A 124
VAL A  94
THR A 117
 None
 0.84A 3cyxA-2eguA:
undetectable		 3cyxA-2eguA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 2egu CYSTEINE SYNTHASE
(Geobacillus
kaustophilus) 		5 / 10 THR A 117
PRO A  71
GLY A  77
GLY A 125
ALA A 126
 None
 1.33A 3pp7B-2eguA:
3.4		 3pp7B-2eguA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2egu CYSTEINE SYNTHASE
(Geobacillus
kaustophilus) 		5 / 12 VAL A 174
ALA A 289
TYR A  32
ALA A 255
HIS A 272
 None
 0.98A 3qxyA-2eguA:
undetectable		 3qxyA-2eguA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 2egu CYSTEINE SYNTHASE
(Geobacillus
kaustophilus) 		5 / 12 VAL A 174
ALA A 289
TYR A  32
ALA A 255
HIS A 272
 None
 0.95A 3rc0B-2eguA:
undetectable		 3rc0B-2eguA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 2egu CYSTEINE SYNTHASE
(Geobacillus
kaustophilus) 		5 / 12 ILE A 290
GLY A 187
ALA A 186
LEU A 170
GLY A 181
 None
 1.08A 3uq6B-2eguA:
undetectable		 3uq6B-2eguA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 2egu CYSTEINE SYNTHASE
(Geobacillus
kaustophilus) 		5 / 12 TYR A  89
ALA A  56
VAL A  83
LEU A  80
ILE A  48
 None
 1.01A 4g1bA-2eguA:
4.2		 4g1bA-2eguA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2egu CYSTEINE SYNTHASE
(Geobacillus
kaustophilus) 		5 / 12 ILE A 291
THR A 158
ILE A 162
LEU A 288
ILE A 290
 None
 0.99A 4i13A-2eguA:
undetectable		 4i13A-2eguA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2egu CYSTEINE SYNTHASE
(Geobacillus
kaustophilus) 		5 / 8 GLU A  36
LEU A 262
VAL A  18
LEU A  33
GLY A 268
 None
 1.21A 4r3aA-2eguA:
undetectable		 4r3aA-2eguA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2egu CYSTEINE SYNTHASE
(Geobacillus
kaustophilus) 		4 / 7 ALA A 186
THR A 158
VAL A  44
GLU A  36
 None
 1.23A 5ecnA-2eguA:
undetectable		 5ecnA-2eguA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2egu CYSTEINE SYNTHASE
(Geobacillus
kaustophilus) 		3 / 3 TYR A 110
TYR A 298
SER A  43
 None
 0.98A 5iktB-2eguA:
undetectable		 5iktB-2eguA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 2egu CYSTEINE SYNTHASE
(Geobacillus
kaustophilus) 		4 / 8 VAL A  44
ASN A  39
GLN A 165
GLU A 161
 None
 1.11A 6hzpA-2eguA:
undetectable		 6hzpA-2eguA:
21.96