SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2egw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
5 / 10 ASP A 162
GLY A 185
GLY A 189
LEU A 213
ALA A 218
None
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 3.6A)
0.77A 1x7pA-2egwA:
11.3
1x7pB-2egwA:
11.2
1x7pA-2egwA:
23.68
1x7pB-2egwA:
23.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
12 / 12 LEU A 161
ASN A 163
PHE A 164
VAL A 184
GLY A 185
GLY A 189
LEU A 207
LEU A 208
THR A 212
LEU A 213
THR A 215
ALA A 218
SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.9A)
SAH  A 300 ( 4.7A)
SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
None
SAH  A 300 ( 3.6A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 4.5A)
SAH  A 300 ( 3.6A)
0.33A 2egvA-2egwA:
35.9
2egvA-2egwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
12 / 12 LEU A 161
ASN A 163
PHE A 164
VAL A 184
GLY A 185
GLY A 189
LEU A 207
LEU A 208
THR A 212
LEU A 213
THR A 215
ALA A 218
SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.9A)
SAH  A 300 ( 4.7A)
SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
None
SAH  A 300 ( 3.6A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 4.5A)
SAH  A 300 ( 3.6A)
0.38A 2egvB-2egwA:
35.8
2egvB-2egwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3K_A_SAMA1254_0
(ESSENTIAL FOR
MITOTIC GROWTH 1)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
6 / 10 LEU A 161
VAL A 184
GLY A 185
LEU A 208
LEU A 213
ALA A 218
SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 3.6A)
0.62A 2v3kA-2egwA:
7.1
2v3kA-2egwA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
6 / 9 VAL A 184
GLY A 185
GLY A 189
LEU A 208
LEU A 213
ALA A 218
SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 3.6A)
0.64A 2z0yA-2egwA:
23.7
2z0yA-2egwA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
6 / 9 VAL A 184
GLY A 185
GLY A 189
LEU A 208
LEU A 213
ALA A 218
SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 3.6A)
0.54A 2z0yB-2egwA:
23.2
2z0yB-2egwA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
5 / 11 SER A 221
ILE A 222
VAL A 184
VAL A 182
ILE A  89
None
None
SAH  A 300 ( 3.7A)
None
None
1.35A 3rf4A-2egwA:
undetectable
3rf4C-2egwA:
undetectable
3rf4A-2egwA:
17.12
3rf4C-2egwA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
5 / 11 ILE A  89
SER A 221
ILE A 222
VAL A 184
VAL A 182
None
None
None
SAH  A 300 ( 3.7A)
None
1.34A 3rf4A-2egwA:
undetectable
3rf4B-2egwA:
undetectable
3rf4A-2egwA:
17.12
3rf4B-2egwA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
5 / 11 ILE A  89
SER A 221
ILE A 222
VAL A 184
VAL A 182
None
None
None
SAH  A 300 ( 3.7A)
None
1.31A 3rf4B-2egwA:
undetectable
3rf4C-2egwA:
undetectable
3rf4B-2egwA:
17.12
3rf4C-2egwA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
3 / 3 PHE A 229
VAL A 182
ILE A  73
None
0.46A 4emaA-2egwA:
undetectable
4emaA-2egwA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
4 / 4 PHE A 190
ASP A 162
GLY A 185
SER A 195
SAH  A 300 ( 4.6A)
None
SAH  A 300 ( 3.6A)
None
1.49A 4xp9C-2egwA:
undetectable
4xp9C-2egwA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
4 / 6 GLY A 185
PRO A 186
GLU A 194
SER A 191
SAH  A 300 ( 3.6A)
None
None
None
0.78A 5ny7A-2egwA:
undetectable
5ny7A-2egwA:
20.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
6 / 11 LEU A 161
GLY A 189
LEU A 208
ARG A 214
THR A 215
ALA A 218
SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
None
SAH  A 300 ( 4.5A)
SAH  A 300 ( 3.6A)
1.00A 5o96A-2egwA:
26.6
5o96B-2egwA:
26.7
5o96A-2egwA:
31.23
5o96B-2egwA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
6 / 9 LEU A 161
GLY A 185
GLY A 189
LEU A 208
LEU A 213
ALA A 218
SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 3.6A)
0.40A 5o96A-2egwA:
26.6
5o96B-2egwA:
26.7
5o96A-2egwA:
31.23
5o96B-2egwA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
4 / 7 GLY A 188
LEU A 213
THR A 215
ALA A 218
SAH  A 300 ( 3.9A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 4.5A)
SAH  A 300 ( 3.6A)
0.75A 5o96C-2egwA:
26.4
5o96C-2egwA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
6 / 7 LEU A 161
GLY A 185
GLY A 189
LEU A 213
THR A 215
ALA A 218
SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 4.5A)
SAH  A 300 ( 3.6A)
0.46A 5o96C-2egwA:
26.4
5o96C-2egwA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
5 / 10 LEU A 161
GLY A 185
GLY A 189
LEU A 213
ALA A 218
SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 3.6A)
0.54A 5o96C-2egwA:
26.4
5o96D-2egwA:
26.2
5o96C-2egwA:
31.23
5o96D-2egwA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
6 / 10 LEU A 161
GLY A 185
GLY A 189
LEU A 213
ARG A 214
ALA A 218
SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 4.0A)
None
SAH  A 300 ( 3.6A)
0.53A 5o96E-2egwA:
26.5
5o96F-2egwA:
26.4
5o96E-2egwA:
31.23
5o96F-2egwA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
8 / 11 LEU A 161
GLY A 185
GLU A 187
GLY A 189
LEU A 208
ARG A 214
THR A 215
ALA A 218
SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
None
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
None
SAH  A 300 ( 4.5A)
SAH  A 300 ( 3.6A)
0.70A 5o96G-2egwA:
26.5
5o96G-2egwA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
8 / 11 LEU A 161
GLY A 185
GLY A 189
LEU A 208
ARG A 214
THR A 215
GLU A 216
ALA A 218
SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
None
SAH  A 300 ( 4.5A)
None
SAH  A 300 ( 3.6A)
0.71A 5o96G-2egwA:
26.5
5o96G-2egwA:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
7 / 10 LEU A 161
GLY A 185
GLY A 189
LEU A 208
LEU A 213
THR A 215
ALA A 218
SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 4.5A)
SAH  A 300 ( 3.6A)
0.46A 5o96G-2egwA:
26.5
5o96H-2egwA:
22.9
5o96G-2egwA:
31.23
5o96H-2egwA:
31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
6 / 11 ASP A 162
GLY A 185
GLY A 189
LEU A 208
THR A 212
LEU A 213
None
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 4.0A)
0.73A 5twjD-2egwA:
7.8
5twjD-2egwA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
6 / 11 LEU A 161
ASP A 162
GLY A 185
GLY A 189
LEU A 208
LEU A 213
SAH  A 300 ( 3.7A)
None
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 4.0A)
0.68A 5twjD-2egwA:
7.8
5twjD-2egwA:
22.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
6 / 10 VAL A 184
GLY A 185
GLY A 189
LEU A 208
LEU A 213
THR A 215
SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 4.5A)
0.76A 5vm8B-2egwA:
25.5
5vm8B-2egwA:
31.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
6 / 10 VAL A 184
GLY A 185
GLY A 189
LEU A 213
THR A 215
ALA A 218
SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 4.5A)
SAH  A 300 ( 3.6A)
0.51A 5vm8B-2egwA:
25.5
5vm8B-2egwA:
31.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
5 / 12 THR A 212
THR A 217
LEU A 148
ASN A 163
PHE A 190
SAH  A 300 ( 4.0A)
None
None
SAH  A 300 ( 3.9A)
SAH  A 300 ( 4.6A)
1.12A 5ybbB-2egwA:
undetectable
5ybbB-2egwA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus)
5 / 9 LEU A 151
SER A 149
ARG A 147
VAL A 102
ILE A 104
None
1.21A 6ef6A-2egwA:
undetectable
6ef6A-2egwA:
20.83