SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2egz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_A_803A311_1
(ANTIGEN CD11A (P180))		 2egz 3-DEHYDROQUINATE
DEHYDRATASE
(Aquifex
aeolicus) 		5 / 10 LEU A  54
VAL A  49
GLU A 196
LEU A 206
VAL A   5
 None
 1.10A 1cqpA-2egzA:
undetectable
1cqpB-2egzA:
undetectable		 1cqpA-2egzA:
24.39
1cqpB-2egzA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 2egz 3-DEHYDROQUINATE
DEHYDRATASE
(Aquifex
aeolicus) 		4 / 6 LEU A 157
GLY A 183
SER A 188
ILE A 170
 None
None
None
TLA  A4988 (-3.8A)
 0.97A 1yajF-2egzA:
undetectable		 1yajF-2egzA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 2egz 3-DEHYDROQUINATE
DEHYDRATASE
(Aquifex
aeolicus) 		3 / 3 ASP A   8
VAL A   5
PRO A 205
 None
 0.80A 2avvA-2egzA:
undetectable		 2avvA-2egzA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAX_I_CSCI1384_1
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 2egz 3-DEHYDROQUINATE
DEHYDRATASE
(Aquifex
aeolicus) 		5 / 12 LEU A 120
THR A 121
ARG A 155
ASN A 124
VAL A 130
 None
 1.45A 2vaxI-2egzA:
1.1		 2vaxI-2egzA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2egz 3-DEHYDROQUINATE
DEHYDRATASE
(Aquifex
aeolicus) 		4 / 4 LEU A 169
ILE A 168
GLY A 183
ILE A 190
 None
 0.89A 5dzk3-2egzA:
undetectable
5dzkm-2egzA:
4.7		 5dzk3-2egzA:
0.91
5dzkm-2egzA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2egz 3-DEHYDROQUINATE
DEHYDRATASE
(Aquifex
aeolicus) 		3 / 3 ARG A  30
PHE A 118
ARG A  61
 TLA  A4988 (-4.0A)
None
TLA  A4988 (-3.1A)
 1.21A 5y9yA-2egzA:
undetectable		 5y9yA-2egzA:
21.77