SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eh3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 2eh3 TRANSCRIPTIONAL
REGULATOR
(Aquifex
aeolicus) 		5 / 12 PHE A  65
ALA A 115
LEU A 142
LEU A 139
ILE A 138
 None
 0.98A 1xdkF-2eh3A:
undetectable		 1xdkF-2eh3A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 2eh3 TRANSCRIPTIONAL
REGULATOR
(Aquifex
aeolicus) 		5 / 12 PHE A  65
ALA A 115
LEU A 142
LEU A 139
ILE A 138
 None
 0.89A 4dm8B-2eh3A:
undetectable		 4dm8B-2eh3A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2eh3 TRANSCRIPTIONAL
REGULATOR
(Aquifex
aeolicus) 		5 / 11 LEU A  76
ILE A  61
GLU A  82
LEU A 164
LEU A 142
 None
None
MG  A1002 ( 2.9A)
None
None
 1.31A 4yvpA-2eh3A:
undetectable		 4yvpA-2eh3A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 2eh3 TRANSCRIPTIONAL
REGULATOR
(Aquifex
aeolicus) 		5 / 12 PHE A  39
THR A  57
ARG A  56
ILE A  54
ILE A  50
 None
 1.17A 5ifuA-2eh3A:
undetectable		 5ifuA-2eh3A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 2eh3 TRANSCRIPTIONAL
REGULATOR
(Aquifex
aeolicus) 		5 / 12 PHE A  65
ALA A 115
LEU A 142
LEU A 139
ILE A 138
 None
 0.94A 5uanB-2eh3A:
undetectable		 5uanB-2eh3A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 2eh3 TRANSCRIPTIONAL
REGULATOR
(Aquifex
aeolicus) 		5 / 10 ILE A 138
LEU A 142
PHE A 119
ASN A  68
LEU A  64
 None
 1.17A 5y7pB-2eh3A:
undetectable		 5y7pB-2eh3A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 2eh3 TRANSCRIPTIONAL
REGULATOR
(Aquifex
aeolicus) 		5 / 10 ILE A 138
LEU A 142
PHE A 119
ASN A  68
LEU A  64
 None
 1.18A 5y7pD-2eh3A:
undetectable		 5y7pD-2eh3A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 2eh3 TRANSCRIPTIONAL
REGULATOR
(Aquifex
aeolicus) 		5 / 10 ILE A 138
LEU A 142
PHE A 119
ASN A  68
LEU A  64
 None
 1.18A 5y7pH-2eh3A:
undetectable		 5y7pH-2eh3A:
20.06