SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eh6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 GLY A 242
GLY A 217
VAL A 247
VAL A  39
ASN A 274
 None
 1.12A 1n2xA-2eh6A:
3.5		 1n2xA-2eh6A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 ASP A 212
ALA A 238
GLY A 129
SER A 126
LEU A 135
 PLP  A1001 (-2.9A)
None
PLP  A1001 ( 4.2A)
None
None
 1.08A 1rjdA-2eh6A:
undetectable		 1rjdA-2eh6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 ASP A 212
ALA A 238
GLY A 129
SER A 126
LEU A 135
 PLP  A1001 (-2.9A)
None
PLP  A1001 ( 4.2A)
None
None
 1.07A 1rjdB-2eh6A:
2.6		 1rjdB-2eh6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		5 / 10 ASP A  32
GLY A  38
GLY A  36
ILE A 358
LEU A  42
 None
 1.11A 1x7pA-2eh6A:
2.5
1x7pB-2eh6A:
2.3		 1x7pA-2eh6A:
20.72
1x7pB-2eh6A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		6 / 12 GLY A 318
GLY A 316
VAL A 298
LEU A 319
PRO A 355
ILE A 359
 None
 1.23A 1zq9B-2eh6A:
undetectable		 1zq9B-2eh6A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		5 / 11 GLY A 217
GLY A 219
THR A 221
ILE A 211
GLN A 228
 None
 1.39A 2dr2A-2eh6A:
undetectable		 2dr2A-2eh6A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		5 / 11 ILE A 218
GLU A 213
HIS A 229
LEU A 292
GLY A 217
 None
 1.02A 2fn1A-2eh6A:
undetectable		 2fn1A-2eh6A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		4 / 8 ILE A 176
ILE A 178
ILE A 237
ALA A 226
 None
 0.66A 2nniA-2eh6A:
undetectable		 2nniA-2eh6A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 ALA A 336
LEU A 371
PHE A 353
ARG A 352
ILE A 364
 None
 0.92A 2w3bA-2eh6A:
undetectable		 2w3bA-2eh6A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		4 / 6 HIS A 128
ALA A 238
ALA A 102
PHE A 120
 None
 1.09A 2xfhA-2eh6A:
undetectable		 2xfhA-2eh6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 LEU A  42
GLY A 242
GLY A  38
GLY A 246
GLY A 245
 None
 0.92A 3axzA-2eh6A:
undetectable		 3axzA-2eh6A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		3 / 3 SER A  94
GLY A  95
THR A  96
 PLP  A1001 (-3.9A)
PLP  A1001 (-3.3A)
PLP  A1001 (-3.5A)
 0.21A 3k9wA-2eh6A:
undetectable		 3k9wA-2eh6A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 TYR A 109
GLY A 175
ALA A 106
ILE A 176
VAL A 207
 None
 1.26A 4azsA-2eh6A:
undetectable		 4azsA-2eh6A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		6 / 12 TYR A 109
GLY A 175
ALA A 106
ILE A 176
VAL A 207
ILE A 201
 None
 1.40A 4aztA-2eh6A:
3.1		 4aztA-2eh6A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		5 / 11 GLY A  95
VAL A  99
GLU A 100
SER A  94
VAL A 214
 PLP  A1001 (-3.3A)
None
None
PLP  A1001 (-3.9A)
PLP  A1001 (-4.3A)
 1.29A 4danA-2eh6A:
undetectable		 4danA-2eh6A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 GLY A 250
ALA A 251
VAL A  89
LEU A  75
ILE A 218
 None
 1.15A 4pd5A-2eh6A:
undetectable		 4pd5A-2eh6A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 GLY A 250
ALA A 251
VAL A  89
LEU A  75
ILE A 218
 None
 1.14A 4pd9A-2eh6A:
undetectable		 4pd9A-2eh6A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		4 / 8 SER A 269
GLY A 272
ALA A 238
GLY A 250
 None
 0.75A 5albL-2eh6A:
undetectable		 5albL-2eh6A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 GLY A 244
GLY A 246
GLY A  43
ALA A 277
LEU A 243
 None
 0.99A 5c0oE-2eh6A:
2.2		 5c0oE-2eh6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 GLY A 244
GLY A 246
GLY A  43
LEU A  42
LEU A 243
 None
 1.02A 5c0oE-2eh6A:
2.2		 5c0oE-2eh6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		6 / 12 GLY A 244
GLY A 246
GLY A  43
LEU A  42
ALA A 277
LEU A 243
 None
 1.38A 5c0oG-2eh6A:
2.3		 5c0oG-2eh6A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 GLY A 219
GLY A 217
THR A 221
VAL A 295
VAL A 285
 None
 0.95A 5kocB-2eh6A:
undetectable		 5kocB-2eh6A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		3 / 3 THR A 270
HIS A  62
ASN A 274
 None
 0.77A 5n4tA-2eh6A:
1.7		 5n4tA-2eh6A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		5 / 12 VAL A 247
LEU A  49
VAL A 283
GLY A 281
VAL A  57
 None
 1.09A 6a94B-2eh6A:
undetectable		 6a94B-2eh6A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		5 / 9 VAL A 288
LEU A  75
GLY A 244
LEU A 243
VAL A 283
 None
 1.34A 6czmB-2eh6A:
undetectable
6czmC-2eh6A:
undetectable		 6czmB-2eh6A:
24.28
6czmC-2eh6A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		5 / 9 VAL A 288
LEU A  75
GLY A 244
LEU A 243
VAL A 283
 None
 1.34A 6czmD-2eh6A:
undetectable
6czmE-2eh6A:
undetectable		 6czmD-2eh6A:
24.28
6czmE-2eh6A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		5 / 10 VAL A 288
LEU A  75
GLY A 244
LEU A 243
VAL A 283
 None
 1.32A 6czmE-2eh6A:
undetectable
6czmF-2eh6A:
undetectable		 6czmE-2eh6A:
24.28
6czmF-2eh6A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		6 / 12 LEU A 291
GLY A 245
GLY A  43
GLU A 287
VAL A 284
ILE A 218
 None
 1.24A 6ecxA-2eh6A:
2.4		 6ecxA-2eh6A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 2eh6 ACETYLORNITHINE
AMINOTRANSFERASE
(Aquifex
aeolicus) 		4 / 7 GLN A 215
GLY A 222
GLY A 318
VAL A 295
 PLP  A1001 (-4.3A)
None
None
None
 0.89A 6ekzA-2eh6A:
undetectable		 6ekzA-2eh6A:
13.46