SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ehb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 2ehb CALCINEURIN B-LIKE
PROTEIN 4
CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24
(Arabidopsis
thaliana) 		3 / 3 PHE A  82
LEU D 324
LEU D 327
 None
 0.62A 1mx1E-2ehbA:
1.3		 1mx1E-2ehbA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2ehb CALCINEURIN B-LIKE
PROTEIN 4
(Arabidopsis
thaliana) 		4 / 7 LYS A  57
GLN A  61
LEU A  45
PHE A  95
 None
 0.96A 1v55P-2ehbA:
undetectable
1v55W-2ehbA:
undetectable		 1v55P-2ehbA:
21.13
1v55W-2ehbA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFM_A_TOPA1290_1
(PTERIDINE REDUCTASE
1)		 2ehb CALCINEURIN B-LIKE
PROTEIN 4
CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24
(Arabidopsis
thaliana) 		5 / 9 PHE A  95
LEU A  41
LEU A 192
LEU D 324
TYR A 194
 None
 1.33A 2bfmA-2ehbA:
undetectable
2bfmD-2ehbA:
undetectable		 2bfmA-2ehbA:
19.53
2bfmD-2ehbA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2ehb CALCINEURIN B-LIKE
PROTEIN 4
(Arabidopsis
thaliana) 		4 / 7 LYS A  57
GLN A  61
LEU A  45
PHE A  95
 None
 0.95A 2eijP-2ehbA:
undetectable
2eijW-2ehbA:
undetectable		 2eijP-2ehbA:
21.13
2eijW-2ehbA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_C_TOPC1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 2ehb CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24
(Arabidopsis
thaliana) 		5 / 10 ILE D 391
LEU D 420
ILE D 350
ILE D 428
THR D 372
 None
 1.04A 2w9sC-2ehbD:
undetectable		 2w9sC-2ehbD:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_A_C2FA401_0
(AMINOMETHYLTRANSFERA
SE)		 2ehb CALCINEURIN B-LIKE
PROTEIN 4
(Arabidopsis
thaliana) 		5 / 12 MET A 190
ILE A  78
ASN A 189
TYR A 119
MET A 135
 None
 1.48A 3a8iA-2ehbA:
undetectable		 3a8iA-2ehbA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_C_C2FC401_0
(AMINOMETHYLTRANSFERA
SE)		 2ehb CALCINEURIN B-LIKE
PROTEIN 4
(Arabidopsis
thaliana) 		5 / 12 MET A 190
ILE A  78
ASN A 189
TYR A 119
MET A 135
 None
 1.48A 3a8iC-2ehbA:
undetectable		 3a8iC-2ehbA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_D_C2FD401_0
(AMINOMETHYLTRANSFERA
SE)		 2ehb CALCINEURIN B-LIKE
PROTEIN 4
(Arabidopsis
thaliana) 		5 / 12 MET A 190
ILE A  78
ASN A 189
TYR A 119
MET A 135
 None
 1.45A 3a8iD-2ehbA:
undetectable		 3a8iD-2ehbA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ehb CALCINEURIN B-LIKE
PROTEIN 4
CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24
(Arabidopsis
thaliana) 		5 / 12 LEU D 327
LEU A 192
PHE A  60
ILE A  78
GLY D 321
 None
 1.11A 3kk6A-2ehbD:
undetectable		 3kk6A-2ehbD:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2ehb CALCINEURIN B-LIKE
PROTEIN 4
CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24
(Arabidopsis
thaliana) 		5 / 12 LEU D 327
LEU A 192
PHE A  60
ILE A  78
GLY D 321
 None
 1.09A 3kk6B-2ehbD:
undetectable		 3kk6B-2ehbD:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 2ehb CALCINEURIN B-LIKE
PROTEIN 4
CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24
(Arabidopsis
thaliana) 		4 / 5 HIS A 103
LEU D 327
LEU A  41
ASP D 329
 None
 1.26A 4aqlA-2ehbA:
undetectable		 4aqlA-2ehbA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 2ehb CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24
(Arabidopsis
thaliana) 		5 / 12 PHE D 416
ARG D 404
ALA D 358
GLU D 390
THR D 372
 None
 1.30A 4fiaA-2ehbD:
undetectable		 4fiaA-2ehbD:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2ehb CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24
(Arabidopsis
thaliana) 		5 / 12 PHE D 416
ARG D 404
ALA D 358
GLU D 390
THR D 372
 None
 1.30A 4fiaA-2ehbD:
undetectable		 4fiaA-2ehbD:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 2ehb CALCINEURIN B-LIKE
PROTEIN 4
(Arabidopsis
thaliana) 		5 / 12 ILE A  55
THR A 201
LEU A  45
LEU A 195
LEU A  99
 None
 1.38A 4qynB-2ehbA:
undetectable		 4qynB-2ehbA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 2ehb CALCINEURIN B-LIKE
PROTEIN 4
CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24
(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		3 / 3 ARG A  70
GLN D 320
GLU A 142
 None
 0.79A 4tvtA-2ehbA:
undetectable		 4tvtA-2ehbA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 2ehb CALCINEURIN B-LIKE
PROTEIN 4
(Arabidopsis
thaliana) 		4 / 6 LEU A  41
LEU A  38
GLU A  40
ILE A 198
 None
 0.93A 4ww7A-2ehbA:
undetectable		 4ww7A-2ehbA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2ehb CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24
(Arabidopsis
thaliana) 		4 / 7 ARG D 368
VAL D 388
HIS D 366
GLU D 375
 None
 1.42A 5ad9A-2ehbD:
undetectable
5ad9B-2ehbD:
undetectable		 5ad9A-2ehbD:
17.16
5ad9B-2ehbD:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2ehb CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24
(Arabidopsis
thaliana) 		3 / 3 VAL D 342
SER D 343
TRP D 429
 None
 1.03A 5jwaA-2ehbD:
undetectable		 5jwaA-2ehbD:
18.35