SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ehd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 2ehd OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Thermus
thermophilus) 		5 / 11 PHE A 144
GLY A 140
GLY A 181
SER A 137
VAL A 203
 None
 1.11A 1mx1A-2ehdA:
3.6		 1mx1A-2ehdA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 2ehd OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Thermus
thermophilus) 		6 / 10 PHE A 114
ALA A 120
ILE A 132
LEU A  82
ASP A 167
LEU A 168
 None
 1.28A 1yi4A-2ehdA:
undetectable		 1yi4A-2ehdA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2ehd OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Thermus
thermophilus) 		4 / 7 GLY A  18
GLY A  12
GLU A 201
ALA A  22
 None
CO  A1001 (-3.6A)
None
None
 0.88A 3fpjB-2ehdA:
7.3		 3fpjB-2ehdA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 2ehd OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Thermus
thermophilus) 		5 / 12 GLY A 130
LEU A  82
LEU A 168
GLU A  78
ALA A 123
 None
 1.12A 3kkzA-2ehdA:
7.0		 3kkzA-2ehdA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ehd OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Thermus
thermophilus) 		5 / 12 LEU A  42
ALA A  22
GLY A  18
SER A  14
LEU A  49
 None
None
None
CO  A1001 (-3.0A)
None
 1.21A 3ou7A-2ehdA:
6.3		 3ou7A-2ehdA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2ehd OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Thermus
thermophilus) 		5 / 12 LEU A  42
ALA A  22
GLY A  18
SER A  14
LEU A  49
 None
None
None
CO  A1001 (-3.0A)
None
 1.23A 3ou7D-2ehdA:
6.3		 3ou7D-2ehdA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 2ehd OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Thermus
thermophilus) 		3 / 3 LYS A  28
LEU A  24
ALA A  27
 None
 0.77A 4iizA-2ehdA:
undetectable		 4iizA-2ehdA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_A_SAMA304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)		 2ehd OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY
(Thermus
thermophilus) 		5 / 12 GLY A 136
ILE A 117
LEU A 160
LEU A 158
ALA A 161
 None
 0.99A 5l0zA-2ehdA:
3.4		 5l0zA-2ehdA:
26.53