SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ehh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 2ehh DIHYDRODIPICOLINATE
SYNTHASE
(Aquifex
aeolicus) 		5 / 11 ALA A 255
LEU A 239
GLU A 213
ALA A 206
VAL A   7
 None
 1.09A 1ictA-2ehhA:
undetectable
1ictC-2ehhA:
undetectable		 1ictA-2ehhA:
20.38
1ictC-2ehhA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 2ehh DIHYDRODIPICOLINATE
SYNTHASE
(Aquifex
aeolicus) 		5 / 12 LEU A 100
ILE A 134
THR A 138
ILE A 173
ARG A 169
 None
 1.15A 1tw4B-2ehhA:
undetectable		 1tw4B-2ehhA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2ehh DIHYDRODIPICOLINATE
SYNTHASE
(Aquifex
aeolicus) 		4 / 6 VAL A 202
SER A 185
LEU A 217
HIS A 233
 None
 1.14A 2f8dA-2ehhA:
undetectable		 2f8dA-2ehhA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_B_RBFB202_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 2ehh DIHYDRODIPICOLINATE
SYNTHASE
(Aquifex
aeolicus) 		5 / 11 GLY A  78
PRO A 104
TYR A 106
ASN A 107
TYR A 105
 PO4  A1001 ( 4.6A)
None
None
None
PO4  A1001 (-4.7A)
 1.48A 2fl5A-2ehhA:
undetectable
2fl5B-2ehhA:
0.0
2fl5F-2ehhA:
undetectable		 2fl5A-2ehhA:
20.14
2fl5B-2ehhA:
21.07
2fl5F-2ehhA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 2ehh DIHYDRODIPICOLINATE
SYNTHASE
(Aquifex
aeolicus) 		5 / 12 ILE A  59
ALA A  96
ALA A  66
LEU A  23
ILE A  27
 None
 1.04A 2h79A-2ehhA:
undetectable		 2h79A-2ehhA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 2ehh DIHYDRODIPICOLINATE
SYNTHASE
(Aquifex
aeolicus) 		5 / 9 ALA A  89
ALA A  96
GLY A  98
HIS A  90
ILE A  59
 None
 1.27A 2v7bA-2ehhA:
2.1		 2v7bA-2ehhA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 2ehh DIHYDRODIPICOLINATE
SYNTHASE
(Aquifex
aeolicus) 		5 / 9 ALA A  89
ALA A  96
GLY A  98
HIS A  90
ILE A  59
 None
 1.23A 2v7bB-2ehhA:
2.5		 2v7bB-2ehhA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2ehh DIHYDRODIPICOLINATE
SYNTHASE
(Aquifex
aeolicus) 		3 / 3 VAL A 284
LYS A 287
HIS A 233
 None
 0.62A 3elzA-2ehhA:
undetectable		 3elzA-2ehhA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM3_B_478B200_2
(PROTEASE)		 2ehh DIHYDRODIPICOLINATE
SYNTHASE
(Aquifex
aeolicus) 		6 / 10 ALA A  96
ASP A  97
ILE A  73
GLY A  75
VAL A 125
ILE A 127
 None
 1.46A 3em3B-2ehhA:
undetectable		 3em3B-2ehhA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 2ehh DIHYDRODIPICOLINATE
SYNTHASE
(Aquifex
aeolicus) 		5 / 12 ILE A  59
ALA A  96
ALA A  66
LEU A  23
ILE A  27
 None
 1.02A 3gwsX-2ehhA:
undetectable		 3gwsX-2ehhA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 2ehh DIHYDRODIPICOLINATE
SYNTHASE
(Aquifex
aeolicus) 		3 / 3 GLY A  45
ILE A  59
VAL A  58
 None
 0.52A 3nv6A-2ehhA:
undetectable		 3nv6A-2ehhA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2ehh DIHYDRODIPICOLINATE
SYNTHASE
(Aquifex
aeolicus) 		5 / 12 ILE A  59
ALA A  96
ALA A  66
LEU A  23
ILE A  27
 None
 1.04A 4lnwA-2ehhA:
undetectable		 4lnwA-2ehhA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2ehh DIHYDRODIPICOLINATE
SYNTHASE
(Aquifex
aeolicus) 		5 / 12 ILE A  59
ALA A  96
ALA A  66
LEU A  23
ILE A  27
 None
 1.05A 4lnxA-2ehhA:
undetectable		 4lnxA-2ehhA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2ehh DIHYDRODIPICOLINATE
SYNTHASE
(Aquifex
aeolicus) 		4 / 8 ILE A 173
VAL A 202
LEU A 184
PHE A 181
 None
 0.99A 4r38B-2ehhA:
undetectable		 4r38B-2ehhA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2ehh DIHYDRODIPICOLINATE
SYNTHASE
(Aquifex
aeolicus) 		5 / 10 ILE A 173
LEU A 222
VAL A 202
LEU A 184
PHE A 181
 None
 1.39A 4r3aB-2ehhA:
undetectable		 4r3aB-2ehhA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2ehh DIHYDRODIPICOLINATE
SYNTHASE
(Aquifex
aeolicus) 		4 / 8 LYS A 200
ILE A 130
ILE A 129
PHE A 181
 None
 0.86A 4v04A-2ehhA:
undetectable		 4v04A-2ehhA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2ehh DIHYDRODIPICOLINATE
SYNTHASE
(Aquifex
aeolicus) 		3 / 3 ALA A  22
ASN A  25
LEU A  26
 None
 0.48A 5i1nC-2ehhA:
undetectable		 5i1nC-2ehhA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 2ehh DIHYDRODIPICOLINATE
SYNTHASE
(Aquifex
aeolicus) 		4 / 7 LEU A 259
THR A  44
MET A 258
LEU A 290
 None
 1.04A 5jq7B-2ehhA:
0.0		 5jq7B-2ehhA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 2ehh DIHYDRODIPICOLINATE
SYNTHASE
(Aquifex
aeolicus) 		5 / 10 ALA A  96
ASP A  97
ILE A  73
GLY A  75
ILE A 127
 None
 0.99A 5kr1A-2ehhA:
undetectable		 5kr1A-2ehhA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 2ehh DIHYDRODIPICOLINATE
SYNTHASE
(Aquifex
aeolicus) 		5 / 10 LEU A 192
PHE A 226
GLY A 198
GLY A   4
VAL A 202
 None
 1.04A 6eu9B-2ehhA:
undetectable		 6eu9B-2ehhA:
13.70