SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ehj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2ehj URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 5 MET A 132
ALA A 134
TYR A 192
ILE A 193
ASP A 199
 None
SO4  A 210 (-3.5A)
None
None
None
 0.72A 1upfA-2ehjA:
26.9		 1upfA-2ehjA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2ehj URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 7 MET A 132
ALA A 134
TYR A 192
ILE A 193
ASP A 199
 None
SO4  A 210 (-3.5A)
None
None
None
 0.81A 1upfB-2ehjA:
26.9		 1upfB-2ehjA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2ehj URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 5 MET A 132
ALA A 134
TYR A 192
ILE A 193
ASP A 199
 None
SO4  A 210 (-3.5A)
None
None
None
 0.89A 1upfC-2ehjA:
26.9		 1upfC-2ehjA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UPF_D_URFD999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2ehj URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		4 / 4 MET A 132
ALA A 134
TYR A 192
ILE A 193
 None
SO4  A 210 (-3.5A)
None
None
 0.65A 1upfD-2ehjA:
27.6		 1upfD-2ehjA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G78_A_REAA200_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 2ehj URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 LEU A 197
ILE A 204
ALA A 200
VAL A 160
LEU A 187
 None
 0.93A 2g78A-2ehjA:
undetectable		 2g78A-2ehjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 2ehj URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 CYH A 151
SER A 152
ALA A 126
THR A  72
ILE A 121
 None
 1.10A 3a35B-2ehjA:
undetectable		 3a35B-2ehjA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 2ehj URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		5 / 12 CYH A 151
SER A 152
ALA A 126
THR A  72
ILE A 121
 None
 1.14A 3ddyA-2ehjA:
undetectable		 3ddyA-2ehjA:
27.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2ehj URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		3 / 3 TYR A 113
MET A 101
ILE A 143
 None
 0.68A 4c8bB-2ehjA:
undetectable		 4c8bB-2ehjA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2ehj URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		3 / 3 ARG A  27
LYS A  26
GLU A  30
 None
 0.76A 5d0yA-2ehjA:
undetectable		 5d0yA-2ehjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2ehj URACIL
PHOSPHORIBOSYLTRANSF
ERASE
(Escherichia
coli) 		4 / 7 VAL A  87
ILE A  96
GLY A 150
ALA A 126
 None
 0.91A 6hd6B-2ehjA:
undetectable		 6hd6B-2ehjA:
17.44