SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ehq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A 477
SER A 323
ALA A 324
GLY A 309
ALA A 325
 None
 0.99A 1gtnL-2ehqA:
undetectable
1gtnV-2ehqA:
undetectable		 1gtnL-2ehqA:
9.82
1gtnV-2ehqA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 HIS A 250
ALA A  76
GLY A  72
TYR A 246
 None
 1.13A 1l5qA-2ehqA:
undetectable		 1l5qA-2ehqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 HIS A 250
ALA A  76
GLY A  72
TYR A 246
 None
 1.12A 1l5qB-2ehqA:
3.6		 1l5qB-2ehqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 HIS A 250
ALA A  76
GLY A  72
TYR A 246
 None
 1.15A 1l7xA-2ehqA:
undetectable		 1l7xA-2ehqA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 PHE A 471
ASN A 472
ILE A 296
GLY A 448
 None
 0.85A 1oniA-2ehqA:
undetectable
1oniB-2ehqA:
undetectable		 1oniA-2ehqA:
14.51
1oniB-2ehqA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 PHE A 471
ASN A 472
ILE A 296
GLY A 448
 None
 0.91A 1oniD-2ehqA:
undetectable
1oniF-2ehqA:
undetectable		 1oniD-2ehqA:
14.51
1oniF-2ehqA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A 309
ALA A 325
GLY A 477
SER A 323
ALA A 324
 None
 0.90A 1utdL-2ehqA:
undetectable
1utdM-2ehqA:
undetectable		 1utdL-2ehqA:
9.82
1utdM-2ehqA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A 309
ALA A 325
GLY A 477
SER A 323
ALA A 324
 None
 0.91A 1utdO-2ehqA:
undetectable
1utdP-2ehqA:
undetectable		 1utdO-2ehqA:
9.82
1utdP-2ehqA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_P_TRPP81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 GLY A 309
ALA A 325
GLY A 477
SER A 323
ALA A 324
 None
 0.94A 1utdP-2ehqA:
undetectable
1utdQ-2ehqA:
undetectable		 1utdP-2ehqA:
9.82
1utdQ-2ehqA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 LYS A 496
ASP A 293
ASN A 468
 None
 0.74A 2bm9A-2ehqA:
3.3		 2bm9A-2ehqA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 TYR A 145
GLU A 137
PHE A 141
VAL A 219
 None
 1.17A 2fl5E-2ehqA:
undetectable
2fl5F-2ehqA:
undetectable		 2fl5E-2ehqA:
15.86
2fl5F-2ehqA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PXC_A_SAMA500_0
(GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)])		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		6 / 12 GLY A 125
GLY A 319
GLY A 316
GLY A 361
GLU A 130
ASP A 293
 None
None
MPD  A1534 ( 4.2A)
None
None
None
 1.29A 2pxcA-2ehqA:
undetectable		 2pxcA-2ehqA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 VAL A 178
ILE A 180
LEU A  40
GLY A 238
ALA A  71
 None
NAP  A1518 (-4.0A)
None
None
None
 1.40A 2xf3B-2ehqA:
undetectable		 2xf3B-2ehqA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B500_1
(ORF12)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 VAL A 178
ILE A 180
LEU A  40
GLY A 238
ALA A  71
 None
NAP  A1518 (-4.0A)
None
None
None
 1.39A 2xfsB-2ehqA:
undetectable		 2xfsB-2ehqA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 VAL A 178
ILE A 180
LEU A  40
GLY A 238
ALA A  71
 None
NAP  A1518 (-4.0A)
None
None
None
 1.40A 2xh9B-2ehqA:
undetectable		 2xh9B-2ehqA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 TRP A 183
SER A 323
CYH A 322
GLN A 318
 NAP  A1518 (-4.0A)
None
NAP  A1518 (-2.0A)
None
 1.22A 2xz5A-2ehqA:
undetectable
2xz5B-2ehqA:
undetectable		 2xz5A-2ehqA:
18.95
2xz5B-2ehqA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 PHE A 506
ASN A 202
PHE A 255
 None
 1.07A 2zbuD-2ehqA:
2.6		 2zbuD-2ehqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_A_PAUA248_0
(TYPE III
PANTOTHENATE KINASE)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 VAL A 363
GLY A 420
THR A 402
ILE A 376
LEU A 373
 None
 1.34A 3bf1A-2ehqA:
undetectable
3bf1B-2ehqA:
2.4		 3bf1A-2ehqA:
21.37
3bf1B-2ehqA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 ASP A 430
LEU A 435
ASP A 298
TRP A 459
 None
 1.22A 3bj8C-2ehqA:
undetectable
3bj8D-2ehqA:
undetectable		 3bj8C-2ehqA:
16.63
3bj8D-2ehqA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 HIS A 250
ALA A  76
GLY A  72
TYR A 246
 None
 1.12A 3dd1A-2ehqA:
1.6		 3dd1A-2ehqA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 HIS A 250
ALA A  76
GLY A  72
TYR A 246
 None
 1.14A 3dd1B-2ehqA:
undetectable		 3dd1B-2ehqA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 HIS A 250
ALA A  76
GLY A  72
TYR A 246
 None
 1.14A 3ddsA-2ehqA:
undetectable		 3ddsA-2ehqA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 HIS A 250
ALA A  76
GLY A  72
TYR A 246
 None
 1.13A 3ddsB-2ehqA:
undetectable		 3ddsB-2ehqA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 HIS A 250
ALA A  76
GLY A  72
TYR A 246
 None
 1.14A 3ddwA-2ehqA:
undetectable		 3ddwA-2ehqA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 HIS A 250
ALA A  76
GLY A  72
TYR A 246
 None
 1.14A 3ddwB-2ehqA:
undetectable		 3ddwB-2ehqA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 THR A 119
ALA A 138
ALA A 131
GLU A 115
ILE A 222
 None
 1.24A 3dl9B-2ehqA:
undetectable		 3dl9B-2ehqA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 TYR A 443
THR A 289
GLU A 367
GLU A 241
 None
 1.06A 3fpjA-2ehqA:
4.9		 3fpjA-2ehqA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 LYS A 371
ILE A 189
PHE A 190
 None
NAP  A1518 (-4.8A)
None
 0.91A 3j7zS-2ehqA:
undetectable
3j7za-2ehqA:
undetectable		 3j7zS-2ehqA:
13.27
3j7za-2ehqA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 GLU A 210
TRP A 183
LYS A 126
ASN A 184
 NAP  A1518 (-3.4A)
NAP  A1518 (-4.0A)
None
NAP  A1518 (-3.2A)
 1.35A 3k8mA-2ehqA:
undetectable		 3k8mA-2ehqA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 GLU A 458
PHE A 431
ARG A 454
PHE A 471
 None
 1.13A 3mjrD-2ehqA:
undetectable		 3mjrD-2ehqA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 TYR A 145
LEU A 503
ARG A 151
GLY A 196
LEU A 500
 None
None
MPD  A1533 (-4.2A)
None
MPD  A1533 ( 3.7A)
 1.33A 3okxA-2ehqA:
undetectable		 3okxA-2ehqA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ASN A 468
GLY A 291
GLY A 447
LEU A 262
PHE A 419
 None
None
None
None
NAP  A1518 (-3.7A)
 1.40A 3r24A-2ehqA:
2.1		 3r24A-2ehqA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 ALA A  71
LEU A  40
ALA A  78
ALA A  79
 None
 0.76A 3r9tA-2ehqA:
undetectable		 3r9tA-2ehqA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		6 / 12 GLY A 125
GLY A 319
GLY A 316
GLY A 361
GLU A 130
ASP A 293
 None
None
MPD  A1534 ( 4.2A)
None
None
None
 1.37A 4ctkA-2ehqA:
3.3		 4ctkA-2ehqA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 6 GLY A 361
VAL A 351
PRO A 353
GLY A 394
GLU A 393
 None
 1.25A 4dxuA-2ehqA:
2.1		 4dxuA-2ehqA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		4 / 6 GLU A 225
ILE A 222
GLU A 123
VAL A  30
 None
None
NA  A1540 (-4.8A)
None
 0.99A 4ejwB-2ehqA:
undetectable		 4ejwB-2ehqA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 LYS A 474
TYR A 470
ARG A 473
 None
 1.08A 4gc9A-2ehqA:
2.5		 4gc9A-2ehqA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		6 / 12 LEU A 120
ASP A 140
ILE A 142
GLY A 192
ILE A 189
VAL A 215
 None
None
None
None
NAP  A1518 (-4.8A)
None
 1.44A 4jecA-2ehqA:
undetectable		 4jecA-2ehqA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 8 ALA A 206
VAL A 233
GLY A 216
VAL A 195
ILE A 194
 None
 1.34A 4ll3A-2ehqA:
undetectable		 4ll3A-2ehqA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 GLY A 361
PRO A 362
GLN A 320
 None
 0.42A 4oltB-2ehqA:
undetectable		 4oltB-2ehqA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		6 / 11 LEU A 120
ASP A 140
ILE A 142
GLY A 192
ILE A 189
VAL A 215
 None
None
None
None
NAP  A1518 (-4.8A)
None
 1.43A 4q1xA-2ehqA:
undetectable		 4q1xA-2ehqA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 TYR A 502
GLY A 196
PRO A 197
 None
 0.60A 4qwpA-2ehqA:
undetectable		 4qwpA-2ehqA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 GLY A 361
PRO A 362
GLN A 320
 None
 0.32A 4qwpB-2ehqA:
undetectable		 4qwpB-2ehqA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 8 LEU A 360
GLY A 361
VAL A 351
ALA A 400
GLY A 420
 None
 1.27A 4zauA-2ehqA:
undetectable		 4zauA-2ehqA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		6 / 12 GLY A 125
GLY A 319
GLY A 316
GLY A 361
GLU A 130
ASP A 293
 None
None
MPD  A1534 ( 4.2A)
None
None
None
 1.33A 5e9qA-2ehqA:
3.4		 5e9qA-2ehqA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		6 / 12 GLY A 125
GLY A 319
GLY A 316
GLY A 361
GLU A 130
ASP A 293
 None
None
MPD  A1534 ( 4.2A)
None
None
None
 1.40A 5e9qC-2ehqA:
3.4		 5e9qC-2ehqA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		6 / 12 GLY A 125
GLY A 319
GLY A 316
GLY A 361
GLU A 130
ASP A 293
 None
None
MPD  A1534 ( 4.2A)
None
None
None
 1.36A 5eifA-2ehqA:
undetectable		 5eifA-2ehqA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		6 / 12 GLY A 125
GLY A 319
GLY A 316
GLY A 361
GLU A 130
ASP A 293
 None
None
MPD  A1534 ( 4.2A)
None
None
None
 1.42A 5eifC-2ehqA:
undetectable		 5eifC-2ehqA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		6 / 12 GLY A 125
GLY A 319
GLY A 316
GLY A 361
GLU A 130
ASP A 293
 None
None
MPD  A1534 ( 4.2A)
None
None
None
 1.40A 5eiwC-2ehqA:
undetectable		 5eiwC-2ehqA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLN A 368
SER A 365
ARG A 370
ILE A 378
TYR A 375
 None
 1.11A 5fepA-2ehqA:
1.1		 5fepA-2ehqA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLN A 368
SER A 365
ARG A 370
ILE A 378
TYR A 375
 None
 1.09A 5fesA-2ehqA:
1.1		 5fesA-2ehqA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ASP A 298
ALA A 301
PRO A 337
LYS A 344
PHE A 303
 None
 1.33A 5hfjC-2ehqA:
undetectable		 5hfjC-2ehqA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 ALA A  79
PRO A 237
LEU A 236
ILE A 205
PHE A 235
 None
 1.45A 5i73A-2ehqA:
3.9		 5i73A-2ehqA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE
(Thermus
thermophilus) 		6 / 12 GLY A 125
GLY A 319
GLY A 316
GLY A 361
GLU A 130
ASP A 293
 None
None
MPD  A1534 ( 4.2A)
None
None
None
 1.30A 5kqrA-2ehqA:
3.3		 5kqrA-2ehqA:
20.93