SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ei8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
5 / 8 HIS A  57
ASP A 189
SER A 195
VAL A 213
GLY A 226
None
DT8  A 700 (-3.5A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.5A)
0.61A 1aq7A-2ei8A:
35.6
1aq7A-2ei8A:
38.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
5 / 8 HIS A  57
ASP A 189
VAL A 213
GLY A 216
GLY A 226
None
DT8  A 700 (-3.5A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
0.48A 1aq7A-2ei8A:
35.6
1aq7A-2ei8A:
38.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
7 / 9 ASP A 189
ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
DT8  A 700 (-3.5A)
DT8  A 700 (-3.6A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.9A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
0.31A 1bcuH-2ei8A:
36.2
1bcuH-2ei8A:
40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
5 / 9 ASP A 189
ALA A 190
VAL A 138
GLY A 226
GLY A 184
DT8  A 700 (-3.5A)
DT8  A 700 (-3.6A)
None
DT8  A 700 (-3.5A)
None
1.23A 1bcuH-2ei8A:
36.2
1bcuH-2ei8A:
40.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
5 / 12 LEU A 155
THR A  73
ASP A 194
LEU A  32
GLY A  40
None
1.37A 1d4fA-2ei8A:
undetectable
1d4fA-2ei8A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
5 / 12 LEU A 155
THR A  73
ASP A 194
LEU A  32
GLY A  40
None
1.39A 1d4fD-2ei8A:
undetectable
1d4fD-2ei8A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
4 / 6 GLY A 226
TYR A 185
ALA A 221
GLU A 188
DT8  A 700 (-3.5A)
None
None
None
0.94A 1dmaB-2ei8A:
undetectable
1dmaB-2ei8A:
19.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
None
DT8  A 700 (-3.5A)
DT8  A 700 ( 3.9A)
DT8  A 700 (-3.9A)
DT8  A 700 (-3.5A)
0.46A 1dwcH-2ei8A:
35.4
1dwcH-2ei8A:
40.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
7 / 12 HIS A  57
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
None
DT8  A 700 (-3.5A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.9A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
0.60A 1etrH-2ei8A:
35.3
1etrH-2ei8A:
40.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
5 / 8 ASP A 189
GLN A 192
SER A 195
VAL A 213
GLY A 226
DT8  A 700 (-3.5A)
DT8  A 700 (-3.9A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.5A)
0.39A 1f5lA-2ei8A:
33.5
1f5lA-2ei8A:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
5 / 8 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
DT8  A 700 (-3.5A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
0.38A 1f5lA-2ei8A:
33.5
1f5lA-2ei8A:
32.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
4 / 8 ASP A 102
PHE A  94
SER A 195
ALA A 104
None
None
DT8  A 700 ( 3.9A)
None
1.02A 1rqpC-2ei8A:
undetectable
1rqpC-2ei8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
4 / 8 ASP A 102
PHE A  94
SER A 195
ALA A 104
None
None
DT8  A 700 ( 3.9A)
None
1.00A 1rqpA-2ei8A:
undetectable
1rqpA-2ei8A:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
5 / 6 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
DT8  A 700 (-3.5A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
0.45A 1tnlA-2ei8A:
35.6
1tnlA-2ei8A:
38.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
4 / 7 HIS A 199
ASP A 189
THR A 135
GLY A 136
None
DT8  A 700 (-3.5A)
None
None
0.87A 2f6dA-2ei8A:
undetectable
2f6dA-2ei8A:
19.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
5 / 6 ASP A 189
SER A 195
VAL A 213
GLY A 216
GLY A 226
DT8  A 700 (-3.5A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
0.28A 2otvA-2ei8A:
35.8
2otvA-2ei8A:
38.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
LEU A  53
None
1.37A 2oxtD-2ei8A:
undetectable
2oxtD-2ei8A:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
10 / 12 TYR A  99
PHE A 174
ASP A 189
ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
DT8  A 700 (-3.4A)
DT8  A 700 (-3.4A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.6A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.9A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
0.28A 2p16A-2ei8A:
46.2
2p16A-2ei8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
3 / 3 ARG A 143
GLU A 147
GLN A 192
None
None
DT8  A 700 (-3.9A)
1.03A 2p16A-2ei8A:
46.2
2p16A-2ei8A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
4 / 5 LEU A 123
PRO A 124
LEU A 235
ILE A 238
None
0.82A 2qd4A-2ei8A:
undetectable
2qd4A-2ei8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
4 / 8 ASP A 102
PHE A  94
SER A 195
ALA A 104
None
None
DT8  A 700 ( 3.9A)
None
1.01A 2v7uA-2ei8A:
undetectable
2v7uA-2ei8A:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
6 / 8 ASP A 189
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
DT8  A 700 (-3.5A)
DT8  A 700 (-3.9A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
0.47A 2vinA-2ei8A:
14.1
2vinA-2ei8A:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
11 / 12 TYR A  99
PHE A 174
ASP A 189
ALA A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 218
GLY A 226
TYR A 228
DT8  A 700 (-3.4A)
DT8  A 700 (-3.4A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.6A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.9A)
DT8  A 700 (-3.5A)
DT8  A 700 (-4.1A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
0.32A 2w26A-2ei8A:
46.6
2w26A-2ei8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
6 / 11 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
None
DT8  A 700 (-3.5A)
DT8  A 700 ( 3.9A)
DT8  A 700 (-3.9A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
0.53A 3gy3A-2ei8A:
35.7
3gy3A-2ei8A:
38.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
5 / 6 SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.9A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
0.35A 3rxfA-2ei8A:
14.1
3rxfA-2ei8A:
38.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
4 / 5 ASP A 189
SER A 195
VAL A 213
GLY A 226
DT8  A 700 (-3.5A)
DT8  A 700 ( 3.9A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.5A)
0.41A 3rxhA-2ei8A:
35.7
3rxhA-2ei8A:
38.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
4 / 4 LEU A 123
PRO A 124
LEU A 235
ILE A 238
None
0.92A 4f4dB-2ei8A:
undetectable
4f4dB-2ei8A:
19.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
4 / 5 HIS A  57
GLN A 192
GLY A 193
SER A 195
None
DT8  A 700 (-3.9A)
None
DT8  A 700 ( 3.9A)
0.32A 4fu8A-2ei8A:
33.7
4fu8A-2ei8A:
33.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
6 / 12 HIS A  57
ASP A 189
ALA A 190
VAL A 213
TRP A 215
GLY A 226
None
DT8  A 700 (-3.5A)
DT8  A 700 (-3.6A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.9A)
DT8  A 700 (-3.5A)
0.42A 4hfpD-2ei8A:
35.1
4hfpD-2ei8A:
40.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
6 / 10 ALA A  55
THR A  54
ALA A 104
ALA A  56
GLY A 211
THR A 229
None
1.48A 4qvyK-2ei8A:
undetectable
4qvyL-2ei8A:
undetectable
4qvyK-2ei8A:
22.51
4qvyL-2ei8A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
6 / 10 ALA A  55
THR A  54
ALA A 104
ALA A  56
GLY A 211
THR A 229
None
1.48A 4qvyY-2ei8A:
undetectable
4qvyZ-2ei8A:
undetectable
4qvyY-2ei8A:
22.51
4qvyZ-2ei8A:
23.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
6 / 12 HIS A  57
ALA A 190
VAL A 213
TRP A 215
GLY A 216
GLY A 226
None
DT8  A 700 (-3.6A)
DT8  A 700 ( 4.1A)
DT8  A 700 (-3.9A)
DT8  A 700 (-3.5A)
DT8  A 700 (-3.5A)
0.63A 4rn6B-2ei8A:
30.0
4rn6B-2ei8A:
40.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
5 / 9 PRO A 198
LEU A  33
ILE A 212
LEU A  53
THR A  54
None
1.14A 4x3mB-2ei8A:
undetectable
4x3mB-2ei8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
5 / 12 GLY A 142
GLY A 196
GLY A  43
GLY A 140
PHE A  94
None
0.92A 5vimA-2ei8A:
undetectable
5vimA-2ei8A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)
2ei8 COAGULATION FACTOR
X, HEAVY CHAIN

(Homo
sapiens)
5 / 12 GLY A 142
GLY A 196
GLY A  43
GLY A 140
PHE A  94
None
0.94A 5vimB-2ei8A:
undetectable
5vimB-2ei8A:
22.18