SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eig'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 2eig LECTIN
(Lotus
tetragonolobus) 		5 / 12 LEU A 146
VAL A 117
ILE A 163
VAL A 140
ILE A 138
 None
 1.04A 1hxbB-2eigA:
undetectable		 1hxbB-2eigA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 2eig LECTIN
(Lotus
tetragonolobus) 		5 / 11 SER A 145
LEU A 102
GLY A 137
HIS A 216
GLU A 214
 MN  A1101 ( 4.1A)
None
None
None
None
 1.26A 1iolA-2eigA:
undetectable		 1iolA-2eigA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 2eig LECTIN
(Lotus
tetragonolobus) 		4 / 5 PHE A  66
LEU A  14
MET A  30
LEU A 102
 None
 1.50A 1skxA-2eigA:
undetectable		 1skxA-2eigA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2eig LECTIN
(Lotus
tetragonolobus) 		4 / 6 HIS A 135
VAL A 174
ILE A 143
LEU A 172
 MN  A1101 (-3.4A)
None
None
None
 0.77A 3kk6A-2eigA:
undetectable		 3kk6A-2eigA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA279_0
(UNIVERSAL STRESS
PROTEIN)		 2eig LECTIN
(Lotus
tetragonolobus) 		4 / 4 SER A 220
SER A  65
THR A  64
SER A 222
 None
None
None
NAG  A1001 (-3.5A)
 1.19A 3loqA-2eigA:
0.0		 3loqA-2eigA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 2eig LECTIN
(Lotus
tetragonolobus) 		4 / 6 PRO A  34
VAL A  70
THR A 207
THR A  39
 None
 1.10A 3tneA-2eigA:
undetectable		 3tneA-2eigA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_1
(ASPARTYL PROTEASE)		 2eig LECTIN
(Lotus
tetragonolobus) 		5 / 12 LEU A 146
VAL A 117
ILE A 163
VAL A 140
ILE A 138
 None
 0.86A 4dqbA-2eigA:
undetectable		 4dqbA-2eigA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 2eig LECTIN
(Lotus
tetragonolobus) 		4 / 5 LEU A 192
SER A 167
LEU A 227
LEU A  86
 None
 1.25A 4n09B-2eigA:
undetectable		 4n09B-2eigA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 2eig LECTIN
(Lotus
tetragonolobus) 		4 / 5 ASN A  58
LEU A 227
SER A  61
LEU A 192
 None
 1.28A 4n09C-2eigA:
undetectable		 4n09C-2eigA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 2eig LECTIN
(Lotus
tetragonolobus) 		4 / 5 LEU A 192
SER A 167
LEU A 227
LEU A  86
 None
 1.25A 4n09D-2eigA:
undetectable		 4n09D-2eigA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_1
(PROTEASE E35D-DRV)		 2eig LECTIN
(Lotus
tetragonolobus) 		5 / 12 LEU A 146
VAL A 117
ILE A 163
VAL A 140
ILE A 138
 None
 1.02A 5kqyA-2eigA:
undetectable		 5kqyA-2eigA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 2eig LECTIN
(Lotus
tetragonolobus) 		3 / 3 TYR A  45
SER A 201
TRP A 221
 None
 1.07A 5n8jD-2eigA:
undetectable		 5n8jD-2eigA:
19.75