SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eih'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2eih ALCOHOL
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 5 THR A 150
THR A 153
THR A 243
HIS A  41
 None
 1.26A 1d4fB-2eihA:
5.0		 1d4fB-2eihA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2eih ALCOHOL
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 LEU A 162
ALA A 192
ILE A 184
VAL A 164
 None
 0.80A 1d4sB-2eihA:
undetectable		 1d4sB-2eihA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 2eih ALCOHOL
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 11 ALA A 254
ALA A 198
ALA A 175
THR A 231
LEU A 171
 None
 1.03A 1jinA-2eihA:
undetectable		 1jinA-2eihA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 2eih ALCOHOL
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 VAL A  86
LEU A 297
PRO A 136
VAL A 304
 None
 0.73A 1jtvA-2eihA:
undetectable		 1jtvA-2eihA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 2eih ALCOHOL
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 ALA A  36
PRO A  89
ASN A  88
LEU A 132
VAL A  32
 None
 1.27A 1u72A-2eihA:
undetectable		 1u72A-2eihA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 2eih ALCOHOL
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 4 ILE A 263
ARG A 282
ILE A 286
THR A 243
 None
 1.19A 3ia4C-2eihA:
2.3		 3ia4C-2eihA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 2eih ALCOHOL
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 GLY A 114
ASP A  43
VAL A  86
ALA A  38
ALA A 145
 None
 1.09A 3keeC-2eihA:
undetectable		 3keeC-2eihA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 2eih ALCOHOL
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 PHE A 335
VAL A 334
VAL A 181
GLN A 185
GLY A 314
 None
 1.20A 3km6A-2eihA:
undetectable		 3km6A-2eihA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 2eih ALCOHOL
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 PHE A 335
VAL A 334
VAL A 181
GLN A 185
GLY A 314
 None
 1.10A 3kmoA-2eihA:
undetectable		 3kmoA-2eihA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2eih ALCOHOL
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 12 PHE A 335
VAL A 181
GLY A 176
GLY A 314
ALA A  38
 None
 1.00A 3sufB-2eihA:
undetectable		 3sufB-2eihA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2eih ALCOHOL
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 7 VAL A 304
LEU A 189
ASN A  88
VAL A 158
 None
 1.13A 4e1gB-2eihA:
undetectable		 4e1gB-2eihA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2eih ALCOHOL
DEHYDROGENASE
(Thermus
thermophilus) 		4 / 8 GLY A 235
ALA A 236
ASP A 237
THR A 197
 None
 0.64A 4eyrB-2eihA:
undetectable		 4eyrB-2eihA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2eih ALCOHOL
DEHYDROGENASE
(Thermus
thermophilus) 		3 / 3 PRO A  21
VAL A  60
HIS A  59
 None
 0.76A 4pevC-2eihA:
4.1		 4pevC-2eihA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2eih ALCOHOL
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 THR A 219
ALA A 198
THR A 197
ALA A 196
ALA A 175
 None
 0.74A 5l5zK-2eihA:
undetectable
5l5zL-2eihA:
undetectable		 5l5zK-2eihA:
20.99
5l5zL-2eihA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-5,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2eih ALCOHOL
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 9 THR A 219
ALA A 198
THR A 197
ALA A 196
ALA A 175
 None
 0.74A 5l5zY-2eihA:
undetectable
5l5zZ-2eihA:
undetectable		 5l5zY-2eihA:
20.99
5l5zZ-2eihA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2eih ALCOHOL
DEHYDROGENASE
(Thermus
thermophilus) 		5 / 10 VAL A 172
VAL A 158
VAL A 179
ALA A 154
LEU A 162
 None
 0.95A 6czmA-2eihA:
undetectable
6czmC-2eihA:
undetectable		 6czmA-2eihA:
22.67
6czmC-2eihA:
22.67