SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2eix'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2eix NADH-CYTOCHROME B5
REDUCTASE
(Physarum
polycephalum) 		5 / 12 LEU A  44
VAL A  78
PHE A 113
VAL A 140
VAL A 104
 None
 1.20A 1q23H-2eixA:
undetectable
1q23I-2eixA:
undetectable		 1q23H-2eixA:
20.75
1q23I-2eixA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 2eix NADH-CYTOCHROME B5
REDUCTASE
(Physarum
polycephalum) 		5 / 9 THR A 184
PHE A 214
VAL A 154
GLY A 158
MET A 159
 None
 1.32A 2w98A-2eixA:
4.5		 2w98A-2eixA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 2eix NADH-CYTOCHROME B5
REDUCTASE
(Physarum
polycephalum) 		4 / 8 GLY A 165
ILE A 280
ASN A 261
MET A 260
 None
 0.80A 2x0pA-2eixA:
undetectable		 2x0pA-2eixA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2eix NADH-CYTOCHROME B5
REDUCTASE
(Physarum
polycephalum) 		5 / 12 GLY A 272
ILE A 166
GLY A 163
GLY A 256
MET A 264
 None
 1.04A 5eqbA-2eixA:
undetectable		 5eqbA-2eixA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2eix NADH-CYTOCHROME B5
REDUCTASE
(Physarum
polycephalum) 		4 / 8 THR A 164
GLY A 165
CYH A 255
GLY A 256
 FAD  A1301 (-3.3A)
None
FAD  A1301 ( 4.1A)
None
 0.44A 5vw5A-2eixA:
20.0		 5vw5A-2eixA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2eix NADH-CYTOCHROME B5
REDUCTASE
(Physarum
polycephalum) 		4 / 8 THR A 164
GLY A 165
CYH A 255
GLY A 256
 FAD  A1301 (-3.3A)
None
FAD  A1301 ( 4.1A)
None
 0.43A 5vw9A-2eixA:
20.2		 5vw9A-2eixA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 2eix NADH-CYTOCHROME B5
REDUCTASE
(Physarum
polycephalum) 		3 / 3 LYS A 155
SER A 244
SER A 248
 None
 1.13A 6gbfA-2eixA:
undetectable		 6gbfA-2eixA:
17.17